ENSG00000111481

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262061 ENSG00000111481 HEK293_OSMI2_2hA HEK293_TMG_2hB COPZ1 protein_coding protein_coding 261.235 398.4538 206.9378 27.17315 7.09314 -0.9451818 183.22975 328.49239 110.88657 20.57908 4.676250 -1.5666891 0.6691167 0.8274667 0.5356000 -0.2918667 0.006914799 0.00533988 FALSE TRUE
ENST00000550027 ENSG00000111481 HEK293_OSMI2_2hA HEK293_TMG_2hB COPZ1 protein_coding retained_intron 261.235 398.4538 206.9378 27.17315 7.09314 -0.9451818 58.78393 41.08469 80.66673 21.19030 3.774519 0.9732006 0.2579792 0.1001667 0.3894667 0.2893000 0.512611617 0.00533988 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111481 E001 0.0000000       12 54301202 54301219 18 +      
ENSG00000111481 E002 0.1482932 4.144590e-02 1.000000e+00   12 54301220 54301380 161 + 0.000 0.080 14.616
ENSG00000111481 E003 0.3666179 3.480752e-02 4.718161e-01 6.109063e-01 12 54325083 54325095 13 + 0.183 0.080 -1.365
ENSG00000111481 E004 4.3510796 3.615025e-03 6.583845e-01 7.675534e-01 12 54325096 54325108 13 + 0.617 0.703 0.367
ENSG00000111481 E005 19.1433605 1.646720e-02 3.119363e-01 4.544541e-01 12 54325109 54325128 20 + 1.309 1.230 -0.278
ENSG00000111481 E006 19.8399760 1.136581e-02 3.118917e-01 4.544171e-01 12 54325129 54325130 2 + 1.320 1.246 -0.258
ENSG00000111481 E007 49.6578654 1.410339e-03 6.175274e-02 1.295757e-01 12 54325131 54325138 8 + 1.705 1.620 -0.289
ENSG00000111481 E008 213.0853656 1.295383e-03 5.439653e-11 1.003726e-09 12 54325139 54325143 5 + 2.395 2.211 -0.614
ENSG00000111481 E009 550.3604627 1.760210e-03 1.767217e-14 5.613582e-13 12 54325144 54325150 7 + 2.803 2.623 -0.599
ENSG00000111481 E010 1193.2336026 3.122632e-03 1.580456e-05 1.003293e-04 12 54325151 54325181 31 + 3.088 2.982 -0.354
ENSG00000111481 E011 2.1055401 1.740663e-02 7.552988e-01 8.406867e-01 12 54325202 54325276 75 + 0.490 0.450 -0.204
ENSG00000111481 E012 2.8765578 5.332852e-03 5.445890e-04 2.326653e-03 12 54325584 54325682 99 + 0.862 0.345 -2.369
ENSG00000111481 E013 1.1362993 1.344983e-01 1.301886e-01 2.344292e-01 12 54340372 54340462 91 + 0.490 0.207 -1.777
ENSG00000111481 E014 10.7398868 1.750807e-02 6.695584e-02 1.383134e-01 12 54340463 54340546 84 + 1.149 0.950 -0.724
ENSG00000111481 E015 1700.3872319 2.115074e-03 3.801493e-08 4.195883e-07 12 54340547 54340615 69 + 3.244 3.135 -0.364
ENSG00000111481 E016 2154.9987986 1.393124e-03 8.570897e-08 8.813128e-07 12 54342206 54342287 82 + 3.328 3.245 -0.274
ENSG00000111481 E017 5.3474931 3.586840e-03 2.417780e-01 3.762887e-01 12 54342288 54342630 343 + 0.862 0.720 -0.564
ENSG00000111481 E018 2154.3881333 7.080565e-04 1.993262e-03 7.205479e-03 12 54343225 54343316 92 + 3.287 3.261 -0.089
ENSG00000111481 E019 1508.9979373 4.437605e-04 1.271514e-01 2.301657e-01 12 54345460 54345515 56 + 3.115 3.113 -0.006
ENSG00000111481 E020 6.5956542 2.520575e-03 3.676355e-02 8.501907e-02 12 54346612 54346674 63 + 0.995 0.753 -0.933
ENSG00000111481 E021 1740.9481419 7.743794e-05 8.599678e-01 9.136945e-01 12 54347767 54347844 78 + 3.159 3.181 0.074
ENSG00000111481 E022 4.0662232 4.151891e-03 2.674083e-01 4.057190e-01 12 54347845 54347972 128 + 0.756 0.606 -0.632
ENSG00000111481 E023 1241.0940183 2.624998e-04 2.174553e-01 3.473311e-01 12 54348000 54348039 40 + 3.001 3.037 0.122
ENSG00000111481 E024 822.0158620 8.951059e-05 7.489313e-03 2.248467e-02 12 54348040 54348051 12 + 2.805 2.865 0.201
ENSG00000111481 E025 4.4492158 3.802765e-03 1.073514e-02 3.053433e-02 12 54348052 54348132 81 + 0.920 0.583 -1.370
ENSG00000111481 E026 1082.8159220 1.600121e-04 8.277644e-10 1.245869e-08 12 54349620 54349658 39 + 2.889 2.995 0.352
ENSG00000111481 E027 17.8654676 1.078761e-03 1.451327e-03 5.478065e-03 12 54349659 54350245 587 + 1.390 1.145 -0.862
ENSG00000111481 E028 19.4475393 1.055248e-02 2.664804e-01 4.046742e-01 12 54350246 54350475 230 + 1.148 1.285 0.485
ENSG00000111481 E029 9260.0934154 2.150024e-03 1.465969e-09 2.106199e-08 12 54350476 54351846 1371 + 3.814 3.924 0.365