ENSG00000111450

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261653 ENSG00000111450 HEK293_OSMI2_2hA HEK293_TMG_2hB STX2 protein_coding protein_coding 13.21104 7.379389 19.66425 0.8659187 0.1101447 1.412782 2.7611042 1.9714375 4.225850 0.66442699 0.6045894 1.0961041 0.21951667 0.26433333 0.21493333 -0.04940000 9.020400e-01 1.056394e-12 FALSE TRUE
ENST00000392373 ENSG00000111450 HEK293_OSMI2_2hA HEK293_TMG_2hB STX2 protein_coding protein_coding 13.21104 7.379389 19.66425 0.8659187 0.1101447 1.412782 5.9396220 3.6262452 8.703483 0.40823725 0.1246143 1.2608000 0.46310833 0.49190000 0.44256667 -0.04933333 3.606814e-01 1.056394e-12 FALSE TRUE
ENST00000540889 ENSG00000111450 HEK293_OSMI2_2hA HEK293_TMG_2hB STX2 protein_coding retained_intron 13.21104 7.379389 19.66425 0.8659187 0.1101447 1.412782 1.7654131 0.8723701 1.499521 0.32766495 0.2889381 0.7746351 0.14511250 0.11660000 0.07613333 -0.04046667 7.796955e-01 1.056394e-12 FALSE TRUE
MSTRG.8318.3 ENSG00000111450 HEK293_OSMI2_2hA HEK293_TMG_2hB STX2 protein_coding   13.21104 7.379389 19.66425 0.8659187 0.1101447 1.412782 0.3688665 0.3651926 0.000000 0.04507719 0.0000000 -5.2295593 0.03218750 0.05036667 0.00000000 -0.05036667 1.056394e-12 1.056394e-12 FALSE TRUE
MSTRG.8318.5 ENSG00000111450 HEK293_OSMI2_2hA HEK293_TMG_2hB STX2 protein_coding   13.21104 7.379389 19.66425 0.8659187 0.1101447 1.412782 1.2380573 0.0000000 2.888987 0.00000000 0.4682718 8.1794049 0.06360833 0.00000000 0.14696667 0.14696667 2.070541e-12 1.056394e-12 FALSE TRUE
MSTRG.8318.6 ENSG00000111450 HEK293_OSMI2_2hA HEK293_TMG_2hB STX2 protein_coding   13.21104 7.379389 19.66425 0.8659187 0.1101447 1.412782 1.0778362 0.5441434 2.300166 0.25130289 0.2227097 2.0596654 0.07259583 0.07686667 0.11700000 0.04013333 5.345074e-01 1.056394e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111450 E001 105.1403566 0.0095598917 1.294688e-05 8.378017e-05 12 130789600 130789961 362 - 1.882 2.180 1.000
ENSG00000111450 E002 147.0363574 0.0079114963 1.103734e-03 4.315502e-03 12 130789962 130790203 242 - 2.063 2.279 0.724
ENSG00000111450 E003 363.6617554 0.0054711375 5.427129e-05 3.031112e-04 12 130790204 130791540 1337 - 2.466 2.652 0.618
ENSG00000111450 E004 32.5922205 0.0247690463 4.059716e-01 5.496327e-01 12 130791541 130791668 128 - 1.456 1.580 0.422
ENSG00000111450 E005 118.7367836 0.0003199580 4.723792e-02 1.042543e-01 12 130791669 130791916 248 - 2.058 2.039 -0.063
ENSG00000111450 E006 46.3048659 0.0005041786 1.609462e-01 2.763573e-01 12 130791917 130791977 61 - 1.660 1.632 -0.095
ENSG00000111450 E007 58.3054635 0.0004452884 1.292838e-01 2.331858e-01 12 130795995 130796120 126 - 1.756 1.730 -0.087
ENSG00000111450 E008 3.9761350 0.0083040495 8.076816e-02 1.607430e-01 12 130798393 130798524 132 - 0.564 0.857 1.217
ENSG00000111450 E009 95.6047608 0.0003194973 3.597996e-01 5.041266e-01 12 130798525 130798635 111 - 1.954 1.968 0.048
ENSG00000111450 E010 90.2006365 0.0003362310 1.165271e-01 2.149890e-01 12 130801153 130801253 101 - 1.938 1.925 -0.043
ENSG00000111450 E011 64.0944924 0.0004638326 1.482901e-01 2.593435e-01 12 130801254 130801290 37 - 1.793 1.774 -0.065
ENSG00000111450 E012 80.6119983 0.0003368715 5.892029e-03 1.832705e-02 12 130801415 130801488 74 - 1.907 1.840 -0.226
ENSG00000111450 E013 86.0282733 0.0044940253 6.329380e-05 3.475399e-04 12 130806982 130807090 109 - 1.959 1.792 -0.564
ENSG00000111450 E014 83.0854888 0.0100138684 5.020691e-02 1.095220e-01 12 130808631 130808704 74 - 1.923 1.838 -0.285
ENSG00000111450 E015 0.3030308 0.3616962909 6.577450e-01   12 130812310 130812443 134 - 0.150 0.000 -9.083
ENSG00000111450 E016 79.4898153 0.0007525422 1.291649e-05 8.360920e-05 12 130812957 130813031 75 - 1.921 1.774 -0.498
ENSG00000111450 E017 72.2622427 0.0033198980 9.803539e-03 2.827770e-02 12 130821689 130821788 100 - 1.863 1.771 -0.312
ENSG00000111450 E018 46.4665299 0.0055903576 7.205408e-03 2.175922e-02 12 130827193 130827262 70 - 1.686 1.547 -0.476
ENSG00000111450 E019 21.9387387 0.0036901995 6.610782e-05 3.613366e-04 12 130827263 130827267 5 - 1.412 1.092 -1.125
ENSG00000111450 E020 33.4966732 0.0008568045 2.914672e-07 2.704491e-06 12 130839070 130839266 197 - 1.590 1.269 -1.110