ENSG00000111424

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000546653 ENSG00000111424 HEK293_OSMI2_2hA HEK293_TMG_2hB VDR protein_coding protein_coding 2.881408 3.997984 2.076455 0.06876074 0.07690742 -0.9418234 0.1211719 0.13680231 0.20748926 0.09555584 0.11542552 0.5670695 0.04261667 0.03426667 0.10236667 0.06810000 0.7497692998 0.0004914302 FALSE FALSE
ENST00000547065 ENSG00000111424 HEK293_OSMI2_2hA HEK293_TMG_2hB VDR protein_coding nonsense_mediated_decay 2.881408 3.997984 2.076455 0.06876074 0.07690742 -0.9418234 0.1244103 0.04726267 0.23856881 0.02363397 0.05418980 2.1179783 0.04605417 0.01203333 0.11413333 0.10210000 0.0004914302 0.0004914302 FALSE TRUE
ENST00000548664 ENSG00000111424 HEK293_OSMI2_2hA HEK293_TMG_2hB VDR protein_coding protein_coding 2.881408 3.997984 2.076455 0.06876074 0.07690742 -0.9418234 0.2012113 0.32573480 0.14484677 0.20335773 0.07965397 -1.1164808 0.06578333 0.08210000 0.06706667 -0.01503333 1.0000000000 0.0004914302 FALSE FALSE
ENST00000549336 ENSG00000111424 HEK293_OSMI2_2hA HEK293_TMG_2hB VDR protein_coding protein_coding 2.881408 3.997984 2.076455 0.06876074 0.07690742 -0.9418234 2.2474351 3.25021572 1.42347110 0.10158561 0.03668391 -1.1854546 0.77058750 0.81266667 0.68833333 -0.12433333 0.1620964650 0.0004914302 FALSE TRUE
MSTRG.7169.3 ENSG00000111424 HEK293_OSMI2_2hA HEK293_TMG_2hB VDR protein_coding   2.881408 3.997984 2.076455 0.06876074 0.07690742 -0.9418234 0.1557694 0.16260563 0.06207857 0.05912703 0.06207857 -1.2598372 0.06511250 0.04060000 0.02810000 -0.01250000 0.7309901829 0.0004914302 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111424 E001 112.1918146 0.0066510842 2.294106e-07 2.174580e-06 12 47841537 47842627 1091 - 1.803 2.072 0.904
ENSG00000111424 E002 127.8648546 0.0002818645 4.248025e-02 9.559268e-02 12 47842628 47844469 1842 - 2.006 2.085 0.267
ENSG00000111424 E003 34.7333883 0.0007362124 7.453806e-01 8.334235e-01 12 47844470 47845005 536 - 1.509 1.506 -0.008
ENSG00000111424 E004 18.6801582 0.0012693235 1.397703e-01 2.477133e-01 12 47846335 47846451 117 - 1.324 1.221 -0.359
ENSG00000111424 E005 20.4729570 0.0011030229 5.992914e-03 1.859170e-02 12 47846657 47846808 152 - 1.418 1.227 -0.666
ENSG00000111424 E006 9.0209011 0.0020431500 8.216634e-03 2.433240e-02 12 47855630 47855633 4 - 1.134 0.867 -0.988
ENSG00000111424 E007 21.3744954 0.0062904953 5.588198e-03 1.752209e-02 12 47855634 47855801 168 - 1.441 1.234 -0.719
ENSG00000111424 E008 20.3800302 0.0011159541 4.358433e-02 9.761684e-02 12 47857129 47857249 121 - 1.378 1.239 -0.485
ENSG00000111424 E009 22.7541443 0.0009144657 4.335375e-02 9.720843e-02 12 47857504 47857647 144 - 1.418 1.288 -0.455
ENSG00000111424 E010 12.5908058 0.0078480225 1.873486e-01 3.104050e-01 12 47857648 47857660 13 - 1.162 1.043 -0.431
ENSG00000111424 E011 13.2508009 0.0025889724 2.863846e-01 4.267786e-01 12 47857661 47857688 28 - 1.162 1.076 -0.311
ENSG00000111424 E012 21.7097060 0.0124285503 2.162688e-01 3.459144e-01 12 47865047 47865177 131 - 1.369 1.277 -0.323
ENSG00000111424 E013 1.2242146 0.0110135213 1.328052e-02 3.657176e-02 12 47878816 47878967 152 - 0.580 0.162 -2.627
ENSG00000111424 E014 22.6955857 0.0018471633 2.990037e-01 4.404908e-01 12 47878968 47879115 148 - 1.369 1.308 -0.214
ENSG00000111424 E015 10.7955821 0.0019101161 2.943359e-01 4.354428e-01 12 47882694 47882774 81 - 1.086 0.994 -0.339
ENSG00000111424 E016 0.2214452 0.0386843247 1.000000e+00   12 47882775 47882935 161 - 0.000 0.089 9.011
ENSG00000111424 E017 3.2847127 0.0189240415 5.368304e-01 6.685324e-01 12 47899837 47899958 122 - 0.523 0.642 0.537
ENSG00000111424 E018 0.8877700 0.0437293624 1.088331e-01 2.038207e-01 12 47904564 47904954 391 - 0.000 0.329 11.225
ENSG00000111424 E019 10.6738894 0.0017405710 2.685894e-01 4.070677e-01 12 47904955 47905040 86 - 0.928 1.067 0.514
ENSG00000111424 E020 0.0000000       12 47942863 47943048 186 -