ENSG00000111412

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261318 ENSG00000111412 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRING1 protein_coding protein_coding 23.09228 29.2495 21.44299 1.609214 1.06615 -0.4477263 9.862505 10.304380 9.473429 1.4210835 0.3850477 -0.1211764 0.4420292 0.35666667 0.44493333 0.08826667 0.58075573 0.02161038 FALSE TRUE
ENST00000547606 ENSG00000111412 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRING1 protein_coding protein_coding 23.09228 29.2495 21.44299 1.609214 1.06615 -0.4477263 2.333474 3.229227 2.203377 0.3982183 0.3454707 -0.5494003 0.0995875 0.11200000 0.10160000 -0.01040000 0.91011527 0.02161038   FALSE
ENST00000547630 ENSG00000111412 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRING1 protein_coding nonsense_mediated_decay 23.09228 29.2495 21.44299 1.609214 1.06615 -0.4477263 3.687803 2.708360 4.727382 0.5793957 0.7836771 0.8013535 0.1660500 0.09103333 0.22166667 0.13063333 0.02161038 0.02161038 FALSE TRUE
MSTRG.8092.3 ENSG00000111412 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRING1 protein_coding   23.09228 29.2495 21.44299 1.609214 1.06615 -0.4477263 5.098744 8.460771 4.357793 1.1421845 0.4853239 -0.9555889 0.2124042 0.28726667 0.20193333 -0.08533333 0.11603809 0.02161038   FALSE
MSTRG.8092.5 ENSG00000111412 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRING1 protein_coding   23.09228 29.2495 21.44299 1.609214 1.06615 -0.4477263 2.016481 4.517555 0.490405 1.6151367 0.4904050 -3.1775640 0.0755500 0.15196667 0.02146667 -0.13050000 0.09592601 0.02161038 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111412 E001 1810.602523 0.0141053839 5.419951e-01 6.728616e-01 12 116710171 116717069 6899 - 3.241 3.255 0.045
ENSG00000111412 E002 198.122530 0.0003002192 2.664098e-15 9.540746e-14 12 116717070 116717335 266 - 2.387 2.222 -0.550
ENSG00000111412 E003 156.742248 0.0002677175 6.498225e-03 1.991859e-02 12 116717336 116717448 113 - 2.219 2.176 -0.143
ENSG00000111412 E004 425.740838 0.0090279773 5.751166e-02 1.223532e-01 12 116717449 116717893 445 - 2.553 2.662 0.360
ENSG00000111412 E005 205.483679 0.0117580946 2.334289e-02 5.846510e-02 12 116719763 116719876 114 - 2.208 2.360 0.508
ENSG00000111412 E006 1.027647 0.2541649501 4.919461e-01 6.291744e-01 12 116719877 116720127 251 - 0.388 0.266 -0.771
ENSG00000111412 E007 191.888210 0.0084024785 6.571079e-02 1.362242e-01 12 116720296 116720447 152 - 2.202 2.319 0.390
ENSG00000111412 E008 177.820023 0.0010997731 1.477879e-01 2.586728e-01 12 116723067 116723223 157 - 2.198 2.274 0.252
ENSG00000111412 E009 100.352729 0.0125789200 8.761015e-01 9.244499e-01 12 116737790 116737853 64 - 1.976 2.010 0.114
ENSG00000111412 E010 66.171635 0.0283658106 2.017490e-01 3.283653e-01 12 116737854 116738070 217 - 1.871 1.776 -0.320