ENSG00000111371

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398637 ENSG00000111371 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A1 protein_coding protein_coding 25.01618 7.258203 37.02234 0.3720952 0.2020449 2.349115 20.0711090 6.5304114 28.0029087 0.21277708 0.73102036 2.0986385 0.84624583 0.90210000 0.75623333 -0.14586667 3.439595e-02 1.075135e-11 FALSE TRUE
ENST00000546893 ENSG00000111371 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A1 protein_coding protein_coding 25.01618 7.258203 37.02234 0.3720952 0.2020449 2.349115 2.6566112 0.1667288 6.0083193 0.03780786 0.43070765 5.0897517 0.07005417 0.02256667 0.16226667 0.13970000 1.075135e-11 1.075135e-11 FALSE TRUE
ENST00000548979 ENSG00000111371 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A1 protein_coding retained_intron 25.01618 7.258203 37.02234 0.3720952 0.2020449 2.349115 0.4538736 0.4885394 0.3986291 0.20405190 0.03765723 -0.2869154 0.02842500 0.06513333 0.01076667 -0.05436667 1.539312e-02 1.075135e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111371 E001 2341.4508249 0.0020107979 3.513101e-39 1.153460e-36 12 46183063 46187800 4738 - 3.185 3.460 0.916
ENSG00000111371 E002 328.1589886 0.0014337201 2.711388e-01 4.098334e-01 12 46187801 46188564 764 - 2.381 2.459 0.261
ENSG00000111371 E003 264.1087962 0.0006443390 6.297788e-01 7.450850e-01 12 46188565 46189071 507 - 2.282 2.378 0.322
ENSG00000111371 E004 2.4925381 0.0431205892 5.891766e-01 7.122520e-01 12 46195725 46196126 402 - 0.459 0.413 -0.245
ENSG00000111371 E005 1.3640767 0.0099584328 5.765350e-01 7.019417e-01 12 46196127 46196276 150 - 0.316 0.253 -0.441
ENSG00000111371 E006 1.0255583 0.0642961289 8.162640e-01 8.837360e-01 12 46196913 46196937 25 - 0.256 0.252 -0.029
ENSG00000111371 E007 5.1583278 0.0609513024 4.640641e-05 2.635241e-04 12 46197378 46197719 342 - 0.438 1.214 3.142
ENSG00000111371 E008 119.8646777 0.0002504996 3.865612e-01 5.307421e-01 12 46197720 46197817 98 - 1.947 2.022 0.252
ENSG00000111371 E009 149.9693962 0.0002647493 1.661943e-05 1.049816e-04 12 46197919 46198060 142 - 2.067 2.009 -0.194
ENSG00000111371 E010 157.3473445 0.0022216369 1.952133e-07 1.874528e-06 12 46198625 46198727 103 - 2.097 1.970 -0.425
ENSG00000111371 E011 89.8243519 0.0018663385 3.555104e-06 2.617480e-05 12 46198728 46198743 16 - 1.859 1.706 -0.519
ENSG00000111371 E012 145.9901516 0.0002451545 1.951404e-11 3.874321e-10 12 46201098 46201198 101 - 2.070 1.899 -0.577
ENSG00000111371 E013 117.4942423 0.0007737882 2.559348e-07 2.402085e-06 12 46203010 46203089 80 - 1.972 1.838 -0.450
ENSG00000111371 E014 129.8930965 0.0026739827 3.967752e-05 2.288702e-04 12 46204301 46204417 117 - 2.009 1.915 -0.314
ENSG00000111371 E015 86.2901083 0.0003414135 3.007473e-05 1.789164e-04 12 46204532 46204590 59 - 1.836 1.725 -0.374
ENSG00000111371 E016 111.0472162 0.0002955343 7.450093e-05 4.017986e-04 12 46206080 46206162 83 - 1.938 1.867 -0.239
ENSG00000111371 E017 110.6923238 0.0049789618 2.213859e-03 7.886294e-03 12 46207155 46207236 82 - 1.936 1.872 -0.216
ENSG00000111371 E018 99.9969346 0.0003003247 5.576812e-06 3.926526e-05 12 46207529 46207582 54 - 1.899 1.786 -0.383
ENSG00000111371 E019 95.0922533 0.0005173532 1.379359e-04 6.945260e-04 12 46207583 46207621 39 - 1.873 1.791 -0.275
ENSG00000111371 E020 100.6960104 0.0024310951 5.121247e-04 2.205011e-03 12 46209054 46209127 74 - 1.898 1.823 -0.254
ENSG00000111371 E021 106.7522985 0.0037850017 7.263509e-03 2.191040e-02 12 46229153 46229231 79 - 1.917 1.881 -0.122
ENSG00000111371 E022 89.7835000 0.0005685155 2.942093e-03 1.009400e-02 12 46229232 46229268 37 - 1.843 1.802 -0.137
ENSG00000111371 E023 110.4081609 0.0003312463 5.646422e-09 7.300196e-08 12 46229564 46229639 76 - 1.948 1.774 -0.584
ENSG00000111371 E024 172.9549381 0.0026522506 4.045751e-12 8.976990e-11 12 46239679 46239893 215 - 2.147 1.928 -0.734
ENSG00000111371 E025 0.1817044 0.0401034189 8.914312e-02   12 46239894 46239895 2 - 0.000 0.253 11.102
ENSG00000111371 E026 89.2818000 0.0047090315 8.583808e-09 1.071333e-07 12 46243200 46243314 115 - 1.871 1.598 -0.924
ENSG00000111371 E027 6.3485601 0.0025611427 5.227431e-01 6.564853e-01 12 46254814 46254936 123 - 0.765 0.759 -0.026
ENSG00000111371 E028 1.3191234 0.2279556975 2.467863e-01 3.821741e-01 12 46267225 46267701 477 - 0.222 0.533 1.852
ENSG00000111371 E029 66.9999663 0.0017076216 4.420199e-05 2.523257e-04 12 46268526 46268859 334 - 1.733 1.581 -0.516
ENSG00000111371 E030 8.1328415 0.0020811792 1.660160e-01 2.830181e-01 12 46268860 46268864 5 - 0.871 0.759 -0.441
ENSG00000111371 E031 53.1996082 0.0012911454 7.735101e-07 6.582480e-06 12 46268865 46269130 266 - 1.648 1.393 -0.874
ENSG00000111371 E032 0.0000000       12 46269655 46269951 297 -      
ENSG00000111371 E033 0.0000000       12 46269980 46270017 38 -