ENSG00000111361

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424014 ENSG00000111361 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B1 protein_coding protein_coding 56.80082 56.19386 60.15145 5.565872 0.9090873 0.09817013 27.362072 31.148878 25.827649 3.2991490 0.5560439 -0.2701685 0.4819833 0.55426667 0.42933333 -0.12493333 9.470729e-05 9.470729e-05 FALSE TRUE
ENST00000537073 ENSG00000111361 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B1 protein_coding protein_coding 56.80082 56.19386 60.15145 5.565872 0.9090873 0.09817013 2.936745 1.343053 3.302356 0.1230584 0.1356828 1.2916389 0.0529375 0.02476667 0.05496667 0.03020000 5.364450e-03 9.470729e-05 FALSE TRUE
MSTRG.8255.2 ENSG00000111361 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B1 protein_coding   56.80082 56.19386 60.15145 5.565872 0.9090873 0.09817013 23.538618 22.611453 26.560480 2.5291279 0.6108778 0.2321327 0.4141833 0.40173333 0.44146667 0.03973333 4.198452e-01 9.470729e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111361 E001 0.8116123 0.2079889628 5.915932e-01 7.143302e-01 12 123620406 123621016 611 - 0.317 0.203 -0.853
ENSG00000111361 E002 695.1672715 0.0008523741 1.589019e-04 7.869163e-04 12 123621017 123621332 316 - 2.799 2.866 0.224
ENSG00000111361 E003 614.6943636 0.0002190144 1.982576e-11 3.930443e-10 12 123621333 123621422 90 - 2.725 2.826 0.337
ENSG00000111361 E004 523.4928131 0.0005858645 1.272937e-10 2.208169e-09 12 123621423 123621511 89 - 2.643 2.763 0.398
ENSG00000111361 E005 677.3787140 0.0001448935 9.932777e-11 1.753387e-09 12 123621512 123621707 196 - 2.775 2.865 0.299
ENSG00000111361 E006 324.1495176 0.0007995810 9.248182e-03 2.690489e-02 12 123621708 123621737 30 - 2.475 2.535 0.199
ENSG00000111361 E007 720.2507115 0.0004325128 1.123049e-01 2.089122e-01 12 123621738 123621920 183 - 2.842 2.865 0.074
ENSG00000111361 E008 555.6301426 0.0001305970 2.340223e-01 3.671682e-01 12 123622636 123622761 126 - 2.755 2.735 -0.068
ENSG00000111361 E009 445.8190472 0.0001162763 4.836003e-03 1.547500e-02 12 123624787 123624862 76 - 2.677 2.627 -0.165
ENSG00000111361 E010 31.9430338 0.0006074945 9.242096e-13 2.282476e-11 12 123625967 123626424 458 - 1.720 1.273 -1.536
ENSG00000111361 E011 394.5466434 0.0001877016 2.759057e-03 9.549210e-03 12 123626425 123626493 69 - 2.627 2.570 -0.191
ENSG00000111361 E012 46.9844713 0.0163508005 1.609139e-04 7.960271e-04 12 123626494 123627043 550 - 1.832 1.513 -1.085
ENSG00000111361 E013 516.7334222 0.0009827098 3.897882e-03 1.285745e-02 12 123627044 123627156 113 - 2.748 2.680 -0.226
ENSG00000111361 E014 1.3651209 0.0097267644 5.004325e-02 1.092505e-01 12 123630047 123630168 122 - 0.545 0.202 -2.080
ENSG00000111361 E015 425.3240252 0.0032904094 2.395816e-02 5.971636e-02 12 123630169 123630233 65 - 2.671 2.586 -0.282
ENSG00000111361 E016 375.6070909 0.0016574959 2.407352e-03 8.484152e-03 12 123630234 123630285 52 - 2.620 2.531 -0.297
ENSG00000111361 E017 0.0000000       12 123630286 123630304 19 -      
ENSG00000111361 E018 509.4784268 0.0005993942 4.137142e-05 2.376426e-04 12 123630397 123630533 137 - 2.751 2.668 -0.276
ENSG00000111361 E019 310.0973096 0.0007841217 1.111145e-04 5.729068e-04 12 123632345 123632446 102 - 2.544 2.448 -0.321
ENSG00000111361 E020 1.4800003 0.0104091591 4.731729e-01 6.121861e-01 12 123632447 123632447 1 - 0.317 0.443 0.726
ENSG00000111361 E021 195.9732407 0.0014629934 1.394773e-04 7.012805e-04 12 123633545 123633766 222 - 2.359 2.235 -0.413