ENSG00000111328

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261692 ENSG00000111328 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK2AP1 protein_coding protein_coding 115.636 153.6361 109.9883 4.532575 1.481804 -0.4821294 53.383461 53.670842 69.57983 0.4677100 6.8625111 0.3744692 0.4643417 0.35006667 0.6322667 0.2822000 1.595339e-03 9.669272e-13 FALSE FALSE
ENST00000538446 ENSG00000111328 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK2AP1 protein_coding protein_coding 115.636 153.6361 109.9883 4.532575 1.481804 -0.4821294 49.377429 89.290790 18.18503 5.9084895 6.5396583 -2.2951289 0.4205625 0.57993333 0.1654667 -0.4144667 4.136686e-04 9.669272e-13 FALSE TRUE
ENST00000544658 ENSG00000111328 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK2AP1 protein_coding protein_coding 115.636 153.6361 109.9883 4.532575 1.481804 -0.4821294 8.814582 6.615914 16.68108 0.5270122 0.8136658 1.3328861 0.0789750 0.04333333 0.1519000 0.1085667 9.669272e-13 9.669272e-13   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111328 E001 43.6574700 5.247693e-04 5.129408e-03 1.628105e-02 12 123250112 123252029 1918 - 1.723 1.575 -0.503
ENSG00000111328 E002 4.0598699 4.028742e-03 1.764303e-01 2.966008e-01 12 123252030 123252103 74 - 0.802 0.612 -0.790
ENSG00000111328 E003 6.1110208 2.789630e-03 3.625723e-01 5.069803e-01 12 123252104 123252241 138 - 0.903 0.789 -0.440
ENSG00000111328 E004 7.9066598 9.394755e-02 4.372603e-01 5.792472e-01 12 123252242 123252487 246 - 1.002 0.870 -0.495
ENSG00000111328 E005 4.1809179 1.218629e-01 1.677867e-01 2.853177e-01 12 123252488 123252542 55 - 0.854 0.563 -1.209
ENSG00000111328 E006 1.2533714 1.405703e-02 5.132215e-01 6.480502e-01 12 123254976 123255002 27 - 0.422 0.307 -0.676
ENSG00000111328 E007 5.0277281 5.689355e-02 2.396094e-01 3.736549e-01 12 123258748 123258857 110 - 0.879 0.687 -0.765
ENSG00000111328 E008 4.8052482 2.607602e-02 9.471908e-01 9.708327e-01 12 123258858 123258930 73 - 0.742 0.751 0.036
ENSG00000111328 E009 3.9697791 4.135635e-03 1.765415e-01 2.967513e-01 12 123258931 123258976 46 - 0.802 0.612 -0.791
ENSG00000111328 E010 5.8215081 1.361879e-02 2.316168e-01 3.643900e-01 12 123258977 123259042 66 - 0.924 0.768 -0.604
ENSG00000111328 E011 11.7990744 1.558115e-03 1.449323e-02 3.934569e-02 12 123259043 123259148 106 - 1.231 1.000 -0.832
ENSG00000111328 E012 20.9685266 1.066135e-03 4.121513e-02 9.327539e-02 12 123260274 123260503 230 - 1.409 1.255 -0.536
ENSG00000111328 E013 15.7813223 3.841543e-02 8.744934e-02 1.712742e-01 12 123260826 123260943 118 - 1.325 1.109 -0.767
ENSG00000111328 E014 1.1856066 1.104896e-02 4.409429e-03 1.429053e-02 12 123260944 123260970 27 - 0.589 0.099 -3.483
ENSG00000111328 E015 1.0340911 1.177584e-02 1.059635e-02 3.020169e-02 12 123260971 123260975 5 - 0.540 0.099 -3.260
ENSG00000111328 E016 6.2079187 4.849591e-03 6.546397e-01 7.647554e-01 12 123260976 123261002 27 - 0.879 0.824 -0.216
ENSG00000111328 E017 18.3624575 1.325002e-02 2.145463e-03 7.676428e-03 12 123261003 123261011 9 - 1.036 1.360 1.153
ENSG00000111328 E018 312.3888633 7.624538e-04 2.495809e-03 8.751128e-03 12 123261012 123261128 117 - 2.425 2.500 0.248
ENSG00000111328 E019 902.1835087 8.628302e-04 1.086150e-10 1.906317e-09 12 123261129 123261275 147 - 2.857 2.970 0.378
ENSG00000111328 E020 1844.8655463 1.033149e-03 6.210492e-08 6.568919e-07 12 123261276 123261483 208 - 3.191 3.269 0.258
ENSG00000111328 E021 2189.0476656 6.314382e-05 1.043031e-02 2.981823e-02 12 123261484 123261803 320 - 3.306 3.326 0.064
ENSG00000111328 E022 4.4409971 2.144085e-01 5.924139e-01 7.149748e-01 12 123265193 123265195 3 - 0.634 0.769 0.559
ENSG00000111328 E023 1090.8418961 1.354223e-03 1.109590e-04 5.722138e-04 12 123265196 123265322 127 - 3.062 2.989 -0.243
ENSG00000111328 E024 683.2625403 1.241758e-03 2.945993e-12 6.695976e-11 12 123267185 123267282 98 - 2.902 2.758 -0.480
ENSG00000111328 E025 6.7730141 4.916981e-02 2.506471e-01 3.867149e-01 12 123267283 123268077 795 - 0.743 0.927 0.719
ENSG00000111328 E026 0.8846626 1.391678e-02 3.795547e-01 5.238253e-01 12 123268169 123268317 149 - 0.150 0.308 1.326
ENSG00000111328 E027 1.8037700 7.691131e-03 6.411996e-01 7.542861e-01 12 123269105 123269239 135 - 0.485 0.406 -0.412
ENSG00000111328 E028 7.7019419 2.237648e-03 2.175726e-02 5.517055e-02 12 123270887 123271141 255 - 1.068 0.807 -0.982
ENSG00000111328 E029 0.9190056 1.530466e-02 8.034403e-01 8.748826e-01 12 123271385 123271563 179 - 0.261 0.307 0.322
ENSG00000111328 E030 307.0884292 2.836482e-03 1.150038e-16 4.908117e-15 12 123271564 123271859 296 - 2.623 2.354 -0.897
ENSG00000111328 E031 19.6077962 9.534983e-04 5.088692e-05 2.862429e-04 12 123272157 123272373 217 - 1.468 1.158 -1.082