ENSG00000111300

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261745 ENSG00000111300 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA25 protein_coding protein_coding 16.69248 4.549757 25.91289 0.1220031 0.3946984 2.507198 11.799050 4.15775693 18.117041 0.10518021 0.9934511 2.120800 0.75819167 0.9140 0.69986667 -0.21413333 1.104993e-04 1.851351e-09 FALSE TRUE
MSTRG.8033.3 ENSG00000111300 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA25 protein_coding   16.69248 4.549757 25.91289 0.1220031 0.3946984 2.507198 1.461553 0.00000000 1.025551 0.00000000 0.5833541 6.694254 0.05199167 0.0000 0.03913333 0.03913333 4.508878e-01 1.851351e-09 FALSE TRUE
MSTRG.8033.4 ENSG00000111300 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA25 protein_coding   16.69248 4.549757 25.91289 0.1220031 0.3946984 2.507198 1.347432 0.06622029 3.573263 0.04125678 0.1833325 5.554955 0.05041250 0.0148 0.13786667 0.12306667 1.851351e-09 1.851351e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111300 E001 194.8837138 0.0125796589 2.666984e-07 2.494210e-06 12 112026689 112027787 1099 - 2.085 2.453 1.230
ENSG00000111300 E002 535.8116545 0.0069168330 5.503725e-09 7.129815e-08 12 112027788 112028967 1180 - 2.548 2.830 0.937
ENSG00000111300 E003 188.5062793 0.0002286056 1.435574e-01 2.528568e-01 12 112028968 112029314 347 - 2.140 2.242 0.342
ENSG00000111300 E004 53.5466466 0.0004103216 4.620603e-01 6.019608e-01 12 112029315 112029386 72 - 1.622 1.630 0.029
ENSG00000111300 E005 49.5375383 0.0012736917 2.070882e-01 3.350491e-01 12 112029387 112029414 28 - 1.594 1.563 -0.107
ENSG00000111300 E006 100.3174143 0.0008771821 7.649707e-01 8.478699e-01 12 112029415 112029549 135 - 1.882 1.922 0.137
ENSG00000111300 E007 105.0200602 0.0003243179 2.915435e-01 4.324107e-01 12 112029550 112029653 104 - 1.889 1.989 0.338
ENSG00000111300 E008 136.0576069 0.0064728782 1.962906e-01 3.215838e-01 12 112033233 112033379 147 - 1.994 2.117 0.410
ENSG00000111300 E009 15.3327545 0.0406825930 6.379169e-03 1.960824e-02 12 112033380 112035405 2026 - 1.002 1.415 1.467
ENSG00000111300 E010 68.8560134 0.0007528058 1.686016e-01 2.863432e-01 12 112039229 112039261 33 - 1.701 1.829 0.432
ENSG00000111300 E011 54.5813137 0.0005318634 1.394849e-01 2.473209e-01 12 112039262 112039269 8 - 1.600 1.741 0.478
ENSG00000111300 E012 79.9920242 0.0027239242 3.763968e-01 5.207189e-01 12 112039270 112039339 70 - 1.770 1.872 0.345
ENSG00000111300 E013 10.6425314 0.0036247045 4.452847e-02 9.933346e-02 12 112039340 112040480 1141 - 0.996 0.751 -0.944
ENSG00000111300 E014 79.2696199 0.0017043996 1.458906e-01 2.560808e-01 12 112040481 112040578 98 - 1.760 1.890 0.438
ENSG00000111300 E015 87.6902329 0.0002883168 9.005657e-01 9.405620e-01 12 112042039 112042104 66 - 1.820 1.880 0.205
ENSG00000111300 E016 0.4417471 0.7133109136 1.000000e+00 1.000000e+00 12 112042105 112042311 207 - 0.149 0.000 -9.676
ENSG00000111300 E017 105.9065692 0.0002737926 9.172706e-01 9.517387e-01 12 112043088 112043211 124 - 1.903 1.953 0.169
ENSG00000111300 E018 171.4737634 0.0002509742 3.630339e-02 8.415914e-02 12 112043625 112043868 244 - 2.123 2.103 -0.066
ENSG00000111300 E019 147.8061475 0.0002195070 1.586119e-02 4.242543e-02 12 112047665 112047790 126 - 2.064 2.025 -0.128
ENSG00000111300 E020 140.3498346 0.0004077133 1.041452e-03 4.102382e-03 12 112048292 112048443 152 - 2.048 1.968 -0.268
ENSG00000111300 E021 10.0932866 0.0017198131 4.848609e-01 6.228001e-01 12 112049483 112049611 129 - 0.945 0.900 -0.169
ENSG00000111300 E022 76.4250816 0.0023692180 6.412772e-01 7.543461e-01 12 112053558 112053657 100 - 1.766 1.793 0.093
ENSG00000111300 E023 103.5850966 0.0076865699 8.708964e-02 1.707309e-01 12 112054388 112054568 181 - 1.910 1.856 -0.182
ENSG00000111300 E024 71.0851061 0.0040262016 4.158664e-02 9.397584e-02 12 112060270 112060359 90 - 1.754 1.676 -0.266
ENSG00000111300 E025 115.9718789 0.0067856938 2.098124e-03 7.528379e-03 12 112061181 112061388 208 - 1.973 1.838 -0.453
ENSG00000111300 E026 97.1899463 0.0006192034 2.928014e-07 2.716205e-06 12 112068880 112068992 113 - 1.908 1.689 -0.740
ENSG00000111300 E027 125.6875720 0.0002651033 1.227178e-05 7.986708e-05 12 112071895 112072064 170 - 2.007 1.867 -0.469
ENSG00000111300 E028 78.1196866 0.0003669895 7.834512e-03 2.336589e-02 12 112074675 112074764 90 - 1.794 1.703 -0.310
ENSG00000111300 E029 88.6453462 0.0005360668 1.080903e-02 3.070717e-02 12 112075678 112075789 112 - 1.848 1.770 -0.260
ENSG00000111300 E030 80.7028156 0.0003066665 2.050607e-04 9.856932e-04 12 112078188 112078266 79 - 1.820 1.668 -0.513
ENSG00000111300 E031 84.9258117 0.0003459512 1.472521e-04 7.352783e-04 12 112078634 112078681 48 - 1.841 1.689 -0.512
ENSG00000111300 E032 88.4659005 0.0002969539 8.490769e-04 3.434432e-03 12 112078682 112078741 60 - 1.854 1.735 -0.404
ENSG00000111300 E033 89.1141666 0.0007102157 2.159736e-03 7.719625e-03 12 112081060 112081134 75 - 1.854 1.747 -0.362
ENSG00000111300 E034 107.6041997 0.0007896562 4.530512e-03 1.462865e-02 12 112087683 112087801 119 - 1.933 1.853 -0.271
ENSG00000111300 E035 0.1817044 0.0405216447 7.959345e-02   12 112090312 112090725 414 - 0.000 0.249 12.797
ENSG00000111300 E036 107.2920490 0.0003094623 2.412153e-05 1.468665e-04 12 112090726 112090864 139 - 1.941 1.792 -0.502
ENSG00000111300 E037 69.3487576 0.0003508747 2.021258e-05 1.252072e-04 12 112093051 112093136 86 - 1.762 1.553 -0.708
ENSG00000111300 E038 2.5809044 0.0091760981 5.671826e-01 6.940315e-01 12 112097241 112097441 201 - 0.485 0.406 -0.413
ENSG00000111300 E039 48.2734843 0.0008735307 1.298564e-03 4.971589e-03 12 112108716 112108931 216 - 1.604 1.423 -0.622