ENSG00000111231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000228827 ENSG00000111231 HEK293_OSMI2_2hA HEK293_TMG_2hB GPN3 protein_coding protein_coding 31.92977 15.43988 48.22561 2.034129 0.9977038 1.642503 26.495623 13.2256864 39.329649 1.5996125 1.0566377 1.571551 0.85489583 0.86100000 0.8154000 -0.04560000 5.066483e-01 9.063843e-05 FALSE TRUE
ENST00000550974 ENSG00000111231 HEK293_OSMI2_2hA HEK293_TMG_2hB GPN3 protein_coding protein_coding 31.92977 15.43988 48.22561 2.034129 0.9977038 1.642503 2.855317 0.7647317 5.556397 0.1692493 0.3577992 2.844975 0.06750417 0.04883333 0.1150667 0.06623333 9.063843e-05 9.063843e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111231 E001 0.7792333 0.0311421210 0.720136037 0.814794801 12 110452486 110452486 1 - 0.255 0.185 -0.585
ENSG00000111231 E002 0.7792333 0.0311421210 0.720136037 0.814794801 12 110452487 110452488 2 - 0.255 0.185 -0.585
ENSG00000111231 E003 2.1442644 0.0082440158 0.082040178 0.162742829 12 110452489 110452563 75 - 0.379 0.673 1.412
ENSG00000111231 E004 37.9829919 0.0393535808 0.039883561 0.090818432 12 110452564 110452667 104 - 1.480 1.701 0.755
ENSG00000111231 E005 289.2767805 0.0017653252 0.003490540 0.011697931 12 110452668 110453096 429 - 2.403 2.489 0.287
ENSG00000111231 E006 216.0033010 0.0002651205 0.580735739 0.705433117 12 110453743 110453811 69 - 2.299 2.318 0.064
ENSG00000111231 E007 170.8203756 0.0002330010 0.523566987 0.657225851 12 110453812 110453829 18 - 2.196 2.219 0.078
ENSG00000111231 E008 179.8237908 0.0001918189 0.083386973 0.164870659 12 110453830 110453871 42 - 2.208 2.262 0.178
ENSG00000111231 E009 220.3958873 0.0001895039 0.964745914 0.981775018 12 110455586 110455682 97 - 2.311 2.317 0.020
ENSG00000111231 E010 124.8477065 0.0002900082 0.644589169 0.756854736 12 110455815 110455837 23 - 2.061 2.081 0.069
ENSG00000111231 E011 183.3689735 0.0002715211 0.068448544 0.140803757 12 110455838 110455930 93 - 2.217 2.273 0.187
ENSG00000111231 E012 237.4773622 0.0002254520 0.104256676 0.196971444 12 110457510 110457634 125 - 2.333 2.378 0.150
ENSG00000111231 E013 287.7822459 0.0001883559 0.466301470 0.605868911 12 110459695 110459819 125 - 2.433 2.422 -0.037
ENSG00000111231 E014 204.1544453 0.0001935000 0.043285200 0.097082308 12 110459820 110459862 43 - 2.297 2.247 -0.165
ENSG00000111231 E015 0.1451727 0.0439438588 1.000000000   12 110464780 110465105 326 - 0.079 0.000 -8.897
ENSG00000111231 E016 238.5610866 0.0002131805 0.002840226 0.009795065 12 110465106 110465185 80 - 2.368 2.297 -0.236
ENSG00000111231 E017 162.6413100 0.0002435293 0.030354832 0.072666697 12 110465186 110465214 29 - 2.199 2.137 -0.207
ENSG00000111231 E018 4.9197214 0.0048142862 0.541302380 0.672305563 12 110468126 110468155 30 - 0.762 0.674 -0.361
ENSG00000111231 E019 157.9352774 0.0004422856 0.002045330 0.007366292 12 110468156 110468195 40 - 2.197 2.102 -0.317
ENSG00000111231 E020 126.1499447 0.0003255648 0.005168479 0.016386124 12 110468196 110468279 84 - 2.100 2.006 -0.315
ENSG00000111231 E021 1.8800450 0.0163949427 0.659101927 0.768007005 12 110468280 110468375 96 - 0.414 0.495 0.415
ENSG00000111231 E022 1.8864764 0.0076958566 0.383966666 0.528175113 12 110468472 110468601 130 - 0.476 0.315 -0.906
ENSG00000111231 E023 1.5071731 0.0086745229 0.178043834 0.298691209 12 110468602 110468721 120 - 0.446 0.185 -1.754
ENSG00000111231 E024 0.4439371 0.0215599501 0.377509425 0.521842757 12 110468857 110469268 412 - 0.204 0.000 -10.483