ENSG00000111196

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320756 ENSG00000111196 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGOHB protein_coding protein_coding 60.18888 56.83833 82.7557 6.110196 0.6792702 0.5419149 4.271500 3.118637 7.442006 0.3133634 0.5172608 1.25209444 0.06574167 0.05530000 0.08990000 0.03460000 9.566625e-03 4.485246e-12 FALSE TRUE
ENST00000539554 ENSG00000111196 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGOHB protein_coding protein_coding 60.18888 56.83833 82.7557 6.110196 0.6792702 0.5419149 25.137669 29.384014 28.884133 4.3220387 0.8334349 -0.02474577 0.43715000 0.51283333 0.34910000 -0.16373333 6.626918e-06 4.485246e-12 FALSE TRUE
ENST00000544176 ENSG00000111196 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGOHB protein_coding retained_intron 60.18888 56.83833 82.7557 6.110196 0.6792702 0.5419149 21.931258 21.329566 24.944046 1.8891281 2.1570373 0.22574291 0.36567083 0.37670000 0.30176667 -0.07493333 2.312863e-01 4.485246e-12   FALSE
ENST00000544850 ENSG00000111196 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGOHB protein_coding nonsense_mediated_decay 60.18888 56.83833 82.7557 6.110196 0.6792702 0.5419149 5.197017 1.375418 13.690273 0.1479569 1.6047100 3.30581160 0.07460417 0.02496667 0.16516667 0.14020000 4.485246e-12 4.485246e-12   FALSE
ENST00000545236 ENSG00000111196 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGOHB protein_coding nonsense_mediated_decay 60.18888 56.83833 82.7557 6.110196 0.6792702 0.5419149 2.761270 1.506972 6.616948 0.3554908 0.7926884 2.12714990 0.04134583 0.02810000 0.07983333 0.05173333 1.627294e-02 4.485246e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111196 E001 128.11041 0.0004524518 1.152839e-25 1.342359e-23 12 10604193 10606012 1820 - 2.242 1.880 -1.212
ENSG00000111196 E002 43.19035 0.0068405313 4.502172e-01 5.913517e-01 12 10606013 10606037 25 - 1.671 1.622 -0.168
ENSG00000111196 E003 241.63085 0.0007990714 2.174117e-02 5.514008e-02 12 10606038 10606259 222 - 2.362 2.418 0.188
ENSG00000111196 E004 190.65947 0.0008011573 2.903554e-01 4.311544e-01 12 10606260 10606269 10 - 2.273 2.301 0.092
ENSG00000111196 E005 370.36156 0.0001439691 3.643067e-05 2.120398e-04 12 10606270 10606374 105 - 2.538 2.610 0.239
ENSG00000111196 E006 428.26681 0.0001245168 3.301854e-08 3.687810e-07 12 10607854 10607936 83 - 2.593 2.681 0.296
ENSG00000111196 E007 13.13741 0.0019102444 6.002808e-06 4.198686e-05 12 10607937 10609097 1161 - 1.304 0.838 -1.702
ENSG00000111196 E008 34.21761 0.0019894178 5.586492e-18 2.819995e-16 12 10609098 10609213 116 - 1.731 1.093 -2.216
ENSG00000111196 E009 28.31099 0.0015927700 1.336002e-22 1.138558e-20 12 10609214 10609276 63 - 1.678 0.838 -2.987
ENSG00000111196 E010 28.52017 0.0098330195 4.262934e-14 1.278253e-12 12 10609277 10609383 107 - 1.669 0.946 -2.542
ENSG00000111196 E011 2.55395 0.0058362759 9.416132e-03 2.732207e-02 12 10609384 10609603 220 - 0.703 0.252 -2.366
ENSG00000111196 E012 2.60695 0.0942470477 4.610834e-01 6.010725e-01 12 10609604 10609830 227 - 0.499 0.617 0.544
ENSG00000111196 E013 525.17835 0.0001121115 7.816754e-07 6.643954e-06 12 10609831 10609941 111 - 2.690 2.761 0.234
ENSG00000111196 E014 472.22065 0.0001586273 4.994586e-01 6.357780e-01 12 10610622 10610680 59 - 2.673 2.682 0.027
ENSG00000111196 E015 30.40915 0.0071365272 7.323011e-09 9.250049e-08 12 10612640 10612814 175 - 1.651 1.169 -1.668
ENSG00000111196 E016 13.99070 0.0012474204 1.386910e-09 2.002637e-08 12 10612815 10612826 12 - 1.364 0.726 -2.358
ENSG00000111196 E017 31.25601 0.0029070922 7.813642e-09 9.822634e-08 12 10612827 10612978 152 - 1.648 1.223 -1.467
ENSG00000111196 E018 474.06352 0.0005372708 8.457342e-01 9.040603e-01 12 10613439 10613540 102 - 2.681 2.673 -0.028
ENSG00000111196 E019 246.26688 0.0012575080 3.842400e-01 5.284015e-01 12 10613541 10613628 88 - 2.386 2.406 0.067