ENSG00000111186

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310594 ENSG00000111186 HEK293_OSMI2_2hA HEK293_TMG_2hB WNT5B protein_coding protein_coding 4.130832 6.74457 3.12995 0.237327 0.1703283 -1.105122 2.0659954 3.583952 1.6565530 0.6983893 0.09154224 -1.108704 0.52983333 0.52646667 0.53310000 0.006633333 1.00000000 0.03730287 FALSE TRUE
ENST00000397196 ENSG00000111186 HEK293_OSMI2_2hA HEK293_TMG_2hB WNT5B protein_coding protein_coding 4.130832 6.74457 3.12995 0.237327 0.1703283 -1.105122 0.1547070 0.000000 0.3278428 0.0000000 0.16430101 5.078280 0.03750417 0.00000000 0.10043333 0.100433333 0.08657272 0.03730287 FALSE TRUE
ENST00000542408 ENSG00000111186 HEK293_OSMI2_2hA HEK293_TMG_2hB WNT5B protein_coding protein_coding 4.130832 6.74457 3.12995 0.237327 0.1703283 -1.105122 0.6325957 1.825442 0.2281989 1.0319054 0.08253712 -2.945889 0.12140417 0.28210000 0.07376667 -0.208333333 0.79694933 0.03730287 FALSE TRUE
MSTRG.6614.2 ENSG00000111186 HEK293_OSMI2_2hA HEK293_TMG_2hB WNT5B protein_coding   4.130832 6.74457 3.12995 0.237327 0.1703283 -1.105122 0.5988248 0.192140 0.8846649 0.1921400 0.13391918 2.145993 0.14244167 0.03033333 0.28223333 0.251900000 0.03730287 0.03730287 FALSE TRUE
MSTRG.6614.4 ENSG00000111186 HEK293_OSMI2_2hA HEK293_TMG_2hB WNT5B protein_coding   4.130832 6.74457 3.12995 0.237327 0.1703283 -1.105122 0.6174923 1.059783 0.0000000 0.9385106 0.00000000 -6.741174 0.15075833 0.14876667 0.00000000 -0.148766667 0.41946928 0.03730287 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111186 E001 0.0000000       12 1529891 1530009 119 +      
ENSG00000111186 E002 3.1031867 0.0120492200 2.412124e-02 6.006199e-02 12 1530697 1530818 122 + 0.793 0.446 -1.541
ENSG00000111186 E003 0.7406253 0.0154917528 1.492497e-03 5.611770e-03 12 1530819 1530852 34 + 0.527 0.000 -15.201
ENSG00000111186 E004 3.5624885 0.0186391792 9.435106e-02 1.819105e-01 12 1530853 1530950 98 + 0.793 0.539 -1.082
ENSG00000111186 E005 0.2214452 0.0400418582 1.000000e+00   12 1574657 1574841 185 + 0.000 0.088 10.240
ENSG00000111186 E006 0.0000000       12 1616660 1617055 396 +      
ENSG00000111186 E007 0.1817044 0.0397524012 1.000000e+00   12 1617056 1617143 88 + 0.000 0.088 10.239
ENSG00000111186 E008 0.2966881 0.0290785164 6.430695e-02   12 1629231 1629371 141 + 0.289 0.000 -13.858
ENSG00000111186 E009 0.1482932 0.0417681911 1.000000e+00   12 1629897 1630226 330 + 0.000 0.087 10.226
ENSG00000111186 E010 0.2214452 0.0400418582 1.000000e+00   12 1630812 1631297 486 + 0.000 0.088 10.240
ENSG00000111186 E011 4.6696405 0.0046406985 4.174214e-01 5.607701e-01 12 1631298 1631314 17 + 0.793 0.681 -0.454
ENSG00000111186 E012 17.6903366 0.0020502863 7.501039e-01 8.368762e-01 12 1631315 1631434 120 + 1.208 1.239 0.107
ENSG00000111186 E013 42.5571186 0.0006533358 4.318771e-01 5.743814e-01 12 1632658 1632905 248 + 1.625 1.586 -0.133
ENSG00000111186 E014 0.0000000       12 1632906 1632906 1 +      
ENSG00000111186 E015 44.7312620 0.0012499106 1.251681e-04 6.374386e-04 12 1639684 1639976 293 + 1.740 1.545 -0.665
ENSG00000111186 E016 0.0000000       12 1644797 1645061 265 +      
ENSG00000111186 E017 218.5606607 0.0012031437 1.085469e-05 7.153402e-05 12 1645794 1647212 1419 + 2.235 2.315 0.266