ENSG00000111142

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323666 ENSG00000111142 HEK293_OSMI2_2hA HEK293_TMG_2hB METAP2 protein_coding protein_coding 87.05351 28.1154 153.983 1.875199 2.262798 2.452919 36.969891 16.565835 61.00720 1.6805147 1.2562547 1.880134 0.47909167 0.5963333 0.39643333 -0.19990000 0.171544115 0.001160557 FALSE  
ENST00000546753 ENSG00000111142 HEK293_OSMI2_2hA HEK293_TMG_2hB METAP2 protein_coding protein_coding 87.05351 28.1154 153.983 1.875199 2.262798 2.452919 7.503223 2.953092 12.48375 0.1590778 0.8196822 2.076031 0.09372083 0.1058667 0.08093333 -0.02493333 0.198868514 0.001160557 FALSE  
ENST00000551840 ENSG00000111142 HEK293_OSMI2_2hA HEK293_TMG_2hB METAP2 protein_coding protein_coding 87.05351 28.1154 153.983 1.875199 2.262798 2.452919 6.678229 3.422033 10.76713 0.3370937 1.0667401 1.650838 0.08480000 0.1213667 0.06990000 -0.05146667 0.004852592 0.001160557 FALSE  
ENST00000553151 ENSG00000111142 HEK293_OSMI2_2hA HEK293_TMG_2hB METAP2 protein_coding protein_coding 87.05351 28.1154 153.983 1.875199 2.262798 2.452919 28.168602 4.447529 53.28004 2.2239691 2.5412724 3.579550 0.25934167 0.1519667 0.34580000 0.19383333 0.624178874 0.001160557 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111142 E001 4.4160993 0.0049811784 5.764967e-01 7.019132e-01 12 95473520 95474080 561 + 0.693 0.627 -0.279
ENSG00000111142 E002 52.0759028 0.0017082387 4.920209e-01 6.292403e-01 12 95474081 95474149 69 + 1.656 1.647 -0.032
ENSG00000111142 E003 52.5187827 0.0017835059 3.724237e-01 5.168945e-01 12 95474150 95474151 2 + 1.663 1.641 -0.074
ENSG00000111142 E004 57.2692346 0.0038110698 3.403487e-01 4.843194e-01 12 95474152 95474154 3 + 1.701 1.672 -0.098
ENSG00000111142 E005 63.5166253 0.0026077194 4.498502e-01 5.910491e-01 12 95474155 95474161 7 + 1.740 1.728 -0.040
ENSG00000111142 E006 633.1503394 0.0011809662 2.376440e-10 3.927148e-09 12 95474162 95474330 169 + 2.754 2.638 -0.388
ENSG00000111142 E007 285.8531598 0.0024764782 8.813123e-05 4.662049e-04 12 95476071 95476073 3 + 2.408 2.302 -0.352
ENSG00000111142 E008 549.4462484 0.0015381388 4.591363e-06 3.296771e-05 12 95476074 95476142 69 + 2.687 2.601 -0.287
ENSG00000111142 E009 410.9142420 0.0017242274 9.204937e-06 6.170291e-05 12 95476143 95476178 36 + 2.563 2.467 -0.321
ENSG00000111142 E010 0.4418608 0.0250093943 5.528713e-01 6.820997e-01 12 95482127 95482210 84 + 0.173 0.000 -9.560
ENSG00000111142 E011 490.5773026 0.0026190443 1.673088e-03 6.196705e-03 12 95483215 95483280 66 + 2.633 2.567 -0.220
ENSG00000111142 E012 2.3129101 0.0774923752 1.585655e-01 2.732079e-01 12 95483281 95483494 214 + 0.518 0.218 -1.819
ENSG00000111142 E013 3.5567931 0.0044589362 1.024485e-01 1.942485e-01 12 95484794 95484873 80 + 0.647 0.361 -1.408
ENSG00000111142 E014 3.9503803 0.0040632231 5.827249e-02 1.236661e-01 12 95485809 95485878 70 + 0.693 0.361 -1.601
ENSG00000111142 E015 516.0066296 0.0009624977 4.473814e-04 1.956849e-03 12 95485879 95485947 69 + 2.651 2.601 -0.168
ENSG00000111142 E016 475.2056616 0.0016848899 3.068107e-02 7.329497e-02 12 95485948 95485981 34 + 2.610 2.585 -0.084
ENSG00000111142 E017 811.0355335 0.0002225211 8.273067e-03 2.447465e-02 12 95494056 95494217 162 + 2.838 2.830 -0.027
ENSG00000111142 E018 741.5328830 0.0005064523 2.332457e-01 3.662743e-01 12 95494957 95495138 182 + 2.796 2.807 0.038
ENSG00000111142 E019 1.0330470 0.0118115066 1.357954e-01 2.422072e-01 12 95495139 95495149 11 + 0.332 0.000 -10.783
ENSG00000111142 E020 593.5940294 0.0003618388 8.614021e-01 9.145938e-01 12 95496004 95496098 95 + 2.695 2.726 0.104
ENSG00000111142 E021 753.2302770 0.0020907336 9.419312e-01 9.675071e-01 12 95504065 95504161 97 + 2.796 2.834 0.127
ENSG00000111142 E022 742.6524263 0.0012083222 6.926350e-02 1.421477e-01 12 95511895 95511998 104 + 2.781 2.855 0.247
ENSG00000111142 E023 589.0758287 0.0008957157 6.172105e-08 6.531234e-07 12 95512801 95512916 116 + 2.659 2.807 0.492
ENSG00000111142 E024 2032.4625408 0.0054298984 5.282861e-06 3.738875e-05 12 95513652 95515839 2188 + 3.189 3.362 0.574