ENSG00000111011

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331738 ENSG00000111011 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC2 protein_coding protein_coding 47.32617 32.03989 59.56038 1.900644 0.8496262 0.8942759 3.149741 3.0998769 3.456579 0.4302652 0.2298183 0.1566553 0.07126250 0.09790000 0.05800000 -0.03990000 1.151698e-01 5.324592e-07 FALSE TRUE
ENST00000392442 ENSG00000111011 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC2 protein_coding processed_transcript 47.32617 32.03989 59.56038 1.900644 0.8496262 0.8942759 4.326335 3.0688752 4.345838 0.3131912 0.8850135 0.5005469 0.09031250 0.09536667 0.07266667 -0.02270000 4.896724e-01 5.324592e-07 FALSE TRUE
ENST00000433877 ENSG00000111011 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC2 protein_coding nonsense_mediated_decay 47.32617 32.03989 59.56038 1.900644 0.8496262 0.8942759 12.025490 7.7557892 15.918085 1.0593674 1.8652408 1.0363684 0.25456250 0.24050000 0.26823333 0.02773333 8.408934e-01 5.324592e-07 FALSE TRUE
ENST00000527796 ENSG00000111011 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC2 protein_coding retained_intron 47.32617 32.03989 59.56038 1.900644 0.8496262 0.8942759 3.456145 0.8433481 5.165665 0.2174608 0.2178240 2.6005379 0.06425833 0.02573333 0.08676667 0.06103333 5.324592e-07 5.324592e-07 FALSE FALSE
ENST00000532695 ENSG00000111011 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC2 protein_coding nonsense_mediated_decay 47.32617 32.03989 59.56038 1.900644 0.8496262 0.8942759 12.669406 11.9910510 13.456731 1.4610174 2.4784529 0.1662389 0.28266250 0.37463333 0.22486667 -0.14976667 1.393059e-01 5.324592e-07 FALSE TRUE
MSTRG.8221.2 ENSG00000111011 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC2 protein_coding   47.32617 32.03989 59.56038 1.900644 0.8496262 0.8942759 6.247353 3.0347167 8.733955 0.5671050 1.0048439 1.5219780 0.12267500 0.09470000 0.14703333 0.05233333 2.960028e-01 5.324592e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111011 E001 5.247434 0.0062401869 2.074665e-02 5.305246e-02 12 122503454 122503737 284 - 0.621 0.934 1.255
ENSG00000111011 E002 4.753147 0.0062618097 3.814891e-03 1.262282e-02 12 122503738 122503846 109 - 0.530 0.934 1.669
ENSG00000111011 E003 5.476732 0.0534885841 2.825088e-02 6.850517e-02 12 122503847 122504039 193 - 0.621 0.971 1.396
ENSG00000111011 E004 101.719402 0.0121314287 3.053237e-02 7.301522e-02 12 122504040 122505058 1019 - 1.939 2.087 0.495
ENSG00000111011 E005 202.442964 0.0027771886 5.238474e-17 2.327969e-15 12 122505059 122505305 247 - 2.147 2.447 1.002
ENSG00000111011 E006 161.253523 0.0002627092 8.975983e-18 4.439877e-16 12 122505306 122505329 24 - 2.080 2.325 0.819
ENSG00000111011 E007 177.026555 0.0034443027 1.045630e-10 1.839631e-09 12 122505330 122505379 50 - 2.118 2.369 0.838
ENSG00000111011 E008 459.620636 0.0004084416 1.492607e-12 3.555386e-11 12 122505380 122505604 225 - 2.595 2.726 0.437
ENSG00000111011 E009 366.772670 0.0002759474 5.077289e-05 2.856693e-04 12 122505605 122505706 102 - 2.522 2.603 0.267
ENSG00000111011 E010 8.353890 0.0022244197 3.218796e-01 4.651486e-01 12 122506372 122506833 462 - 1.023 0.913 -0.410
ENSG00000111011 E011 322.359636 0.0001944124 3.767462e-02 8.672139e-02 12 122506834 122506923 90 - 2.484 2.527 0.144
ENSG00000111011 E012 3.509474 0.0044722954 3.487968e-01 4.930140e-01 12 122506924 122507253 330 - 0.720 0.579 -0.603
ENSG00000111011 E013 3.996373 0.0040921732 2.196643e-01 3.499860e-01 12 122507873 122508217 345 - 0.761 0.579 -0.771
ENSG00000111011 E014 220.351768 0.0001872092 1.668844e-02 4.425248e-02 12 122508218 122508249 32 - 2.314 2.373 0.197
ENSG00000111011 E015 299.141303 0.0001787942 1.937021e-04 9.368703e-04 12 122508250 122508366 117 - 2.438 2.517 0.262
ENSG00000111011 E016 131.372711 0.0020205750 6.677007e-02 1.380217e-01 12 122508367 122508377 11 - 2.087 2.157 0.234
ENSG00000111011 E017 196.952484 0.0005185782 1.707364e-04 8.382921e-04 12 122508378 122508447 70 - 2.246 2.348 0.341
ENSG00000111011 E018 53.648997 0.0004419826 7.618428e-06 5.199353e-05 12 122508448 122508450 3 - 1.624 1.841 0.733
ENSG00000111011 E019 102.682925 0.0003149685 7.732342e-07 6.580723e-06 12 122511109 122511110 2 - 1.926 2.100 0.587
ENSG00000111011 E020 245.563420 0.0018029123 6.789050e-02 1.398705e-01 12 122511111 122511188 78 - 2.363 2.419 0.185
ENSG00000111011 E021 9.649649 0.0377559063 7.683671e-02 1.544323e-01 12 122513767 122513874 108 - 1.121 0.867 -0.942
ENSG00000111011 E022 3.142508 0.1467837480 5.379342e-03 1.695928e-02 12 122513875 122513917 43 - 0.802 0.145 -3.749
ENSG00000111011 E023 1.425613 0.2968344263 7.860337e-01 8.629762e-01 12 122514712 122514728 17 - 0.366 0.413 0.266
ENSG00000111011 E024 4.029887 0.0039402838 7.138986e-03 2.158479e-02 12 122514773 122515104 332 - 0.835 0.415 -1.868
ENSG00000111011 E025 237.983925 0.0016602718 9.661707e-01 9.827656e-01 12 122515105 122515162 58 - 2.375 2.375 0.001
ENSG00000111011 E026 266.488299 0.0001967893 2.388560e-01 3.727977e-01 12 122515163 122515227 65 - 2.434 2.409 -0.085
ENSG00000111011 E027 168.919508 0.0002403336 3.545995e-02 8.253714e-02 12 122517227 122517230 4 - 2.252 2.194 -0.193
ENSG00000111011 E028 175.287604 0.0004171132 5.003153e-02 1.092300e-01 12 122517231 122517235 5 - 2.267 2.213 -0.181
ENSG00000111011 E029 460.130059 0.0004084963 5.482377e-05 3.058291e-04 12 122517236 122517430 195 - 2.690 2.616 -0.247
ENSG00000111011 E030 157.211012 0.0049682283 5.124810e-02 1.113726e-01 12 122518839 122518839 1 - 2.231 2.144 -0.291
ENSG00000111011 E031 282.261238 0.0017335996 3.436230e-03 1.154247e-02 12 122518840 122518929 90 - 2.483 2.399 -0.282
ENSG00000111011 E032 253.829472 0.0037395666 3.634895e-02 8.424517e-02 12 122518930 122519029 100 - 2.436 2.358 -0.259
ENSG00000111011 E033 34.320974 0.0006821683 2.119879e-08 2.460060e-07 12 122519030 122519051 22 - 1.668 1.305 -1.250
ENSG00000111011 E034 49.567353 0.0156961810 5.126159e-06 3.639392e-05 12 122519052 122519442 391 - 1.825 1.451 -1.273
ENSG00000111011 E035 30.431945 0.0010462416 7.089427e-10 1.082598e-08 12 122519443 122519664 222 - 1.635 1.198 -1.512
ENSG00000111011 E036 42.775482 0.0010511912 1.617222e-19 9.772818e-18 12 122519665 122519909 245 - 1.809 1.230 -1.988
ENSG00000111011 E037 37.868467 0.0005229034 2.127357e-20 1.426120e-18 12 122519910 122520140 231 - 1.765 1.139 -2.164
ENSG00000111011 E038 16.541619 0.0010936457 5.731249e-12 1.240594e-10 12 122520141 122520201 61 - 1.431 0.732 -2.564
ENSG00000111011 E039 24.880165 0.0186045784 1.024650e-07 1.038392e-06 12 122520202 122520503 302 - 1.575 1.012 -1.978
ENSG00000111011 E040 31.419478 0.0008448017 6.957400e-06 4.794858e-05 12 122520504 122520545 42 - 1.613 1.313 -1.032
ENSG00000111011 E041 32.702666 0.0006023021 6.061590e-08 6.421462e-07 12 122520546 122520581 36 - 1.646 1.287 -1.234
ENSG00000111011 E042 37.213265 0.0069234425 4.792951e-15 1.652731e-13 12 122520582 122520977 396 - 1.758 1.127 -2.180
ENSG00000111011 E043 21.223830 0.0491066199 1.372750e-04 6.915109e-04 12 122520978 122521295 318 - 1.498 0.984 -1.822
ENSG00000111011 E044 11.239237 0.0016143428 2.529194e-05 1.531608e-04 12 122521296 122521384 89 - 1.228 0.763 -1.730
ENSG00000111011 E045 162.458724 0.0035268655 3.148943e-02 7.486075e-02 12 122521385 122521428 44 - 2.247 2.159 -0.291
ENSG00000111011 E046 261.334718 0.0002372616 1.599990e-10 2.727065e-09 12 122522143 122522299 157 - 2.475 2.328 -0.492
ENSG00000111011 E047 3.982658 0.0039233043 2.555868e-02 6.303804e-02 12 122522300 122522329 30 - 0.817 0.477 -1.479
ENSG00000111011 E048 5.553885 0.0028667417 7.098182e-04 2.934113e-03 12 122522330 122522442 113 - 0.965 0.477 -2.041
ENSG00000111011 E049 5.416675 0.0030963917 2.098389e-01 3.383637e-01 12 122522799 122522906 108 - 0.867 0.699 -0.671
ENSG00000111011 E050 13.636162 0.0020013365 1.267646e-08 1.532850e-07 12 122522907 122523756 850 - 1.341 0.732 -2.253
ENSG00000111011 E051 9.327783 0.0018688693 2.258571e-05 1.383023e-04 12 122526170 122526293 124 - 1.170 0.662 -1.940
ENSG00000111011 E052 166.865546 0.0003002513 8.896314e-09 1.107055e-07 12 122526848 122527000 153 - 2.288 2.122 -0.555