ENSG00000110955

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262030 ENSG00000110955 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5F1B protein_coding protein_coding 1072.708 1494.814 808.1685 230.8779 10.31539 -0.8872295 325.62182 454.198780 259.2313 66.4578553 12.20916 -0.8090597 0.3076667 0.3064000000 0.3211000 0.0147000 0.882938878 1.006038e-14 FALSE TRUE
MSTRG.7476.2 ENSG00000110955 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5F1B protein_coding   1072.708 1494.814 808.1685 230.8779 10.31539 -0.8872295 614.92207 984.288485 360.8631 170.9250670 30.54022 -1.4476044 0.5486375 0.6552333333 0.4457667 -0.2094667 0.000451692 1.006038e-14 FALSE TRUE
MSTRG.7476.7 ENSG00000110955 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5F1B protein_coding   1072.708 1494.814 808.1685 230.8779 10.31539 -0.8872295 78.96409 1.070675 139.9327 0.6872876 11.34592 7.0167589 0.0912375 0.0009333333 0.1735333 0.1726000 0.000169159 1.006038e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110955 E001 2664.120852 1.134594e-03 3.456075e-14 1.050615e-12 12 56638175 56638279 105 - 3.271 3.403 0.437
ENSG00000110955 E002 6509.035081 9.368184e-04 4.825181e-19 2.757514e-17 12 56638280 56638375 96 - 3.659 3.789 0.432
ENSG00000110955 E003 7063.481298 1.241499e-03 4.324421e-08 4.724617e-07 12 56638376 56638423 48 - 3.728 3.815 0.289
ENSG00000110955 E004 9450.627830 7.843066e-04 4.829781e-11 8.996043e-10 12 56639106 56639187 82 - 3.860 3.940 0.267
ENSG00000110955 E005 5694.136638 8.837351e-04 2.007028e-05 1.244356e-04 12 56639188 56639196 9 - 3.660 3.715 0.181
ENSG00000110955 E006 9715.563489 5.338568e-04 1.350323e-06 1.090522e-05 12 56639197 56639307 111 - 3.900 3.944 0.146
ENSG00000110955 E007 31.639898 2.775558e-03 6.466706e-05 3.542384e-04 12 56639308 56639418 111 - 1.646 1.375 -0.930
ENSG00000110955 E008 28.602423 5.315504e-03 3.762815e-03 1.247666e-02 12 56639959 56639979 21 - 1.572 1.348 -0.773
ENSG00000110955 E009 4896.470699 4.728355e-05 2.663975e-11 5.175165e-10 12 56639980 56639990 11 - 3.614 3.652 0.128
ENSG00000110955 E010 11031.678342 4.512254e-04 5.931781e-02 1.254698e-01 12 56639991 56640099 109 - 3.984 3.989 0.019
ENSG00000110955 E011 8674.501150 1.292456e-03 8.080136e-01 8.779998e-01 12 56640100 56640150 51 - 3.891 3.880 -0.036
ENSG00000110955 E012 6230.955176 1.647487e-03 3.823688e-01 5.265928e-01 12 56640151 56640159 9 - 3.737 3.740 0.010
ENSG00000110955 E013 7029.792930 1.751306e-03 3.217841e-01 4.650426e-01 12 56640160 56640192 33 - 3.787 3.793 0.019
ENSG00000110955 E014 10871.113541 5.645298e-04 4.803404e-02 1.056949e-01 12 56642458 56642580 123 - 3.975 3.984 0.028
ENSG00000110955 E015 5182.868743 4.051522e-05 1.631611e-04 8.055244e-04 12 56642673 56642684 12 - 3.653 3.672 0.062
ENSG00000110955 E016 5258.130389 3.112509e-05 1.036166e-03 4.083342e-03 12 56642685 56642710 26 - 3.662 3.678 0.052
ENSG00000110955 E017 8811.678694 5.710885e-04 3.609237e-02 8.376448e-02 12 56642711 56642831 121 - 3.883 3.893 0.032
ENSG00000110955 E018 125.386412 2.807266e-04 1.019508e-67 1.399585e-64 12 56642832 56642967 136 - 2.384 1.827 -1.868
ENSG00000110955 E019 113.870193 4.244374e-04 1.520256e-70 2.360720e-67 12 56642968 56643178 211 - 2.362 1.754 -2.039
ENSG00000110955 E020 4796.684174 7.327712e-04 1.004731e-03 3.974844e-03 12 56643403 56643419 17 - 3.603 3.635 0.107
ENSG00000110955 E021 4009.822677 7.246720e-04 2.201328e-02 5.570567e-02 12 56643420 56643420 1 - 3.536 3.554 0.061
ENSG00000110955 E022 10859.083688 1.103390e-03 2.465572e-02 6.117175e-02 12 56643421 56643587 167 - 4.019 3.966 -0.176
ENSG00000110955 E023 8038.694265 9.126378e-04 4.478138e-08 4.876249e-07 12 56643837 56643903 67 - 3.920 3.823 -0.322
ENSG00000110955 E024 8162.320142 8.356015e-04 1.980191e-10 3.319541e-09 12 56643904 56643958 55 - 3.934 3.826 -0.358
ENSG00000110955 E025 8.084637 2.890396e-03 4.927535e-01 6.298923e-01 12 56643959 56643985 27 - 0.976 0.892 -0.314
ENSG00000110955 E026 5444.983087 1.052754e-03 5.675724e-11 1.043728e-09 12 56644781 56644783 3 - 3.769 3.645 -0.413
ENSG00000110955 E027 11514.068316 9.275621e-04 6.134274e-13 1.558428e-11 12 56644784 56644955 172 - 4.092 3.971 -0.403
ENSG00000110955 E028 5596.754652 6.574636e-04 5.399946e-16 2.113207e-14 12 56645171 56645217 47 - 3.781 3.658 -0.409
ENSG00000110955 E029 7545.115069 1.851947e-03 1.580961e-03 5.896995e-03 12 56645218 56645353 136 - 3.883 3.798 -0.279
ENSG00000110955 E030 9.790038 1.329267e-02 6.359792e-12 1.367431e-10 12 56645604 56645637 34 - 1.405 0.600 -3.032
ENSG00000110955 E031 4900.666151 3.760774e-03 2.057721e-01 3.333895e-01 12 56645837 56646310 474 - 3.676 3.619 -0.191
ENSG00000110955 E032 1.664927 8.241432e-03 5.085883e-01 6.439768e-01 12 56651894 56651955 62 - 0.476 0.357 -0.641