ENSG00000110931

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000545538 ENSG00000110931 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMKK2 protein_coding protein_coding 27.38511 33.16888 24.23482 1.819632 0.8575484 -0.4525883 6.9434057 12.530325 2.667989 2.328647 0.4515872 -2.22735260 0.2374917 0.3739333 0.10956667 -0.26436667 4.230724e-05 4.230724e-05 FALSE TRUE
MSTRG.8182.1 ENSG00000110931 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMKK2 protein_coding   27.38511 33.16888 24.23482 1.819632 0.8575484 -0.4525883 6.7066853 7.155886 6.584204 1.173434 0.8686894 -0.11994673 0.2455833 0.2131000 0.26993333 0.05683333 4.875359e-01 4.230724e-05 TRUE TRUE
MSTRG.8182.24 ENSG00000110931 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMKK2 protein_coding   27.38511 33.16888 24.23482 1.819632 0.8575484 -0.4525883 0.3276948 0.000000 2.023948 0.000000 1.0928819 7.66813876 0.0138625 0.0000000 0.08096667 0.08096667 1.536712e-01 4.230724e-05 FALSE TRUE
MSTRG.8182.6 ENSG00000110931 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMKK2 protein_coding   27.38511 33.16888 24.23482 1.819632 0.8575484 -0.4525883 10.4382804 11.487872 11.323173 1.678140 0.7177200 -0.02081499 0.3889208 0.3510000 0.47036667 0.11936667 4.378358e-01 4.230724e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110931 E001 1.8779687 0.0082297790 8.311379e-02 1.644335e-01 12 121217413 121217475 63 - 0.583 0.342 -1.235
ENSG00000110931 E002 1.0642801 0.0124591340 1.136027e-01 2.107861e-01 12 121217476 121217510 35 - 0.442 0.204 -1.557
ENSG00000110931 E003 0.1482932 0.0411452303 6.576656e-01   12 121237673 121237674 2 - 0.000 0.114 27.157
ENSG00000110931 E004 0.1482932 0.0411452303 6.576656e-01   12 121237675 121237675 1 - 0.000 0.114 27.157
ENSG00000110931 E005 1.2500354 0.2683516891 8.331780e-01 8.954772e-01 12 121237676 121237686 11 - 0.313 0.391 0.462
ENSG00000110931 E006 1.5789888 0.4426408084 8.141992e-01 8.822719e-01 12 121237687 121237690 4 - 0.382 0.438 0.303
ENSG00000110931 E007 1.7272820 0.4568764219 7.205692e-01 8.151632e-01 12 121237691 121237691 1 - 0.382 0.478 0.509
ENSG00000110931 E008 12.1746835 0.0420956584 3.646797e-01 5.090147e-01 12 121237692 121237696 5 - 0.993 1.195 0.732
ENSG00000110931 E009 29.0302028 0.0142659856 1.997091e-02 5.142204e-02 12 121237697 121237735 39 - 1.287 1.578 1.006
ENSG00000110931 E010 30.3106306 0.0143778777 5.234530e-02 1.133369e-01 12 121237736 121237744 9 - 1.332 1.585 0.873
ENSG00000110931 E011 52.8491640 0.0052233675 5.681526e-03 1.777090e-02 12 121237745 121237769 25 - 1.568 1.818 0.849
ENSG00000110931 E012 2014.4052035 0.0061622083 1.033945e-11 2.147547e-10 12 121237770 121239876 2107 - 3.122 3.389 0.889
ENSG00000110931 E013 268.9945909 0.0004608248 2.802316e-02 6.805850e-02 12 121239877 121240084 208 - 2.345 2.476 0.437
ENSG00000110931 E014 218.8280135 0.0002281036 6.512848e-01 7.621920e-01 12 121240085 121240234 150 - 2.296 2.364 0.226
ENSG00000110931 E015 280.1056735 0.0001580192 5.183211e-06 3.675765e-05 12 121240235 121240524 290 - 2.455 2.436 -0.061
ENSG00000110931 E016 62.9440362 0.0005074788 1.122953e-02 3.171533e-02 12 121240525 121240542 18 - 1.819 1.783 -0.122
ENSG00000110931 E017 52.7551016 0.0004928758 1.765220e-02 4.638735e-02 12 121240543 121240546 4 - 1.746 1.708 -0.128
ENSG00000110931 E018 189.0128100 0.0046095976 9.554899e-02 1.837172e-01 12 121240547 121240869 323 - 2.267 2.274 0.021
ENSG00000110931 E019 30.3011228 0.0082279007 7.389377e-02 1.497358e-01 12 121243588 121244088 501 - 1.346 1.560 0.737
ENSG00000110931 E020 8.5296156 0.0036236277 1.021910e-01 1.938538e-01 12 121244089 121244129 41 - 0.799 1.061 0.988
ENSG00000110931 E021 8.8348114 0.0023564805 4.748083e-01 6.136148e-01 12 121244573 121244615 43 - 0.887 1.038 0.562
ENSG00000110931 E022 154.8759901 0.0039501402 9.864673e-02 1.884247e-01 12 121245140 121245240 101 - 2.181 2.189 0.028
ENSG00000110931 E023 138.4444166 0.0058955959 5.141467e-02 1.116680e-01 12 121248606 121248734 129 - 2.146 2.129 -0.058
ENSG00000110931 E024 202.3011319 0.0013356616 3.912203e-03 1.289705e-02 12 121249787 121249874 88 - 2.308 2.298 -0.032
ENSG00000110931 E025 191.4418575 0.0012895065 1.459925e-05 9.337870e-05 12 121249961 121250034 74 - 2.311 2.258 -0.177
ENSG00000110931 E026 168.4573083 0.0022453506 1.582716e-02 4.235158e-02 12 121252661 121252714 54 - 2.230 2.222 -0.024
ENSG00000110931 E027 0.0000000       12 121253261 121253272 12 -      
ENSG00000110931 E028 316.7067861 0.0001749725 3.794221e-12 8.464482e-11 12 121253273 121253472 200 - 2.533 2.473 -0.202
ENSG00000110931 E029 155.0623995 0.0002139756 6.456847e-10 9.925595e-09 12 121255550 121255574 25 - 2.242 2.145 -0.326
ENSG00000110931 E030 183.6468057 0.0002009294 4.541930e-10 7.168666e-09 12 121255575 121255638 64 - 2.309 2.224 -0.284
ENSG00000110931 E031 116.6938158 0.0002629871 2.221887e-08 2.567897e-07 12 121255783 121255804 22 - 2.124 2.019 -0.352
ENSG00000110931 E032 110.4612335 0.0002620780 1.163455e-05 7.616210e-05 12 121260319 121260355 37 - 2.083 2.014 -0.231
ENSG00000110931 E033 0.6234634 0.0177254494 5.009943e-01 6.371983e-01 12 121260356 121260542 187 - 0.131 0.278 1.348
ENSG00000110931 E034 138.3337459 0.0002727565 4.878253e-06 3.482179e-05 12 121263806 121263899 94 - 2.174 2.114 -0.201
ENSG00000110931 E035 103.3264785 0.0052001917 4.064453e-02 9.221538e-02 12 121263900 121263939 40 - 2.027 2.000 -0.090
ENSG00000110931 E036 0.1451727 0.0429547323 3.565174e-01   12 121268636 121268637 2 - 0.131 0.000 -27.905
ENSG00000110931 E037 102.0748392 0.0091399178 1.208209e-02 3.373244e-02 12 121268638 121268689 52 - 2.046 1.974 -0.241
ENSG00000110931 E038 97.1117740 0.0098061300 7.831373e-03 2.335837e-02 12 121269528 121269581 54 - 2.030 1.946 -0.284
ENSG00000110931 E039 2.2572590 0.0063089056 9.020370e-02 1.754355e-01 12 121269582 121269627 46 - 0.621 0.398 -1.083
ENSG00000110931 E040 0.1472490 0.0427886093 3.560472e-01   12 121269789 121269884 96 - 0.131 0.000 -27.905
ENSG00000110931 E041 89.2036510 0.0117956886 2.267710e-02 5.708734e-02 12 121270898 121270945 48 - 1.987 1.916 -0.238
ENSG00000110931 E042 54.4803568 0.0100306185 6.370739e-02 1.328765e-01 12 121274056 121274063 8 - 1.765 1.717 -0.162
ENSG00000110931 E043 103.9551021 0.0152174998 1.306289e-01 2.350323e-01 12 121274064 121274151 88 - 2.028 2.003 -0.082
ENSG00000110931 E044 109.2538454 0.0199823108 3.335841e-01 4.773186e-01 12 121274152 121274264 113 - 2.032 2.036 0.012
ENSG00000110931 E045 131.4219502 0.0107096720 3.276568e-01 4.711359e-01 12 121274265 121274585 321 - 2.105 2.120 0.052
ENSG00000110931 E046 1.2532576 0.0512831377 6.403887e-01 7.536322e-01 12 121276323 121276467 145 - 0.382 0.341 -0.242
ENSG00000110931 E047 0.1472490 0.0427886093 3.560472e-01   12 121283690 121283813 124 - 0.131 0.000 -27.905
ENSG00000110931 E048 2.7356474 0.2460076065 5.827032e-01 7.069900e-01 12 121293152 121293274 123 - 0.443 0.618 0.827
ENSG00000110931 E049 1.0308543 0.0436054324 6.940025e-01 7.949255e-01 12 121296266 121296312 47 - 0.314 0.279 -0.229
ENSG00000110931 E050 31.2706817 0.0006779811 2.860595e-04 1.323203e-03 12 121296638 121296757 120 - 1.585 1.438 -0.504
ENSG00000110931 E051 0.0000000       12 121297115 121297434 320 -      
ENSG00000110931 E052 0.0000000       12 121297435 121297538 104 -      
ENSG00000110931 E053 2.0543574 0.0182724184 1.864278e-02 4.854934e-02 12 121297539 121298308 770 - 0.131 0.603 3.093