ENSG00000110921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000228510 ENSG00000110921 HEK293_OSMI2_2hA HEK293_TMG_2hB MVK protein_coding protein_coding 24.58989 45.44305 9.25381 1.635612 0.1638865 -2.2947 14.9973619 27.561375 5.0639028 4.06349948 0.1588268 -2.4420034 0.58489167 0.60156667 0.5481000 -0.05346667 0.7908355137 0.0008136789 FALSE TRUE
ENST00000392727 ENSG00000110921 HEK293_OSMI2_2hA HEK293_TMG_2hB MVK protein_coding protein_coding 24.58989 45.44305 9.25381 1.635612 0.1638865 -2.2947 2.0749090 4.362767 0.3365478 0.20084940 0.1684623 -3.6574205 0.07248750 0.09660000 0.0370000 -0.05960000 0.4057771003 0.0008136789 FALSE TRUE
ENST00000539575 ENSG00000110921 HEK293_OSMI2_2hA HEK293_TMG_2hB MVK protein_coding protein_coding 24.58989 45.44305 9.25381 1.635612 0.1638865 -2.2947 0.5350608 2.855571 0.0000000 2.85557077 0.0000000 -8.1626787 0.01269167 0.06770000 0.0000000 -0.06770000 1.0000000000 0.0008136789 FALSE TRUE
ENST00000540353 ENSG00000110921 HEK293_OSMI2_2hA HEK293_TMG_2hB MVK protein_coding retained_intron 24.58989 45.44305 9.25381 1.635612 0.1638865 -2.2947 1.3141600 1.689839 0.7459059 0.06750888 0.0741877 -1.1691199 0.06370417 0.03720000 0.0806000 0.04340000 0.0008136789 0.0008136789 FALSE FALSE
ENST00000546277 ENSG00000110921 HEK293_OSMI2_2hA HEK293_TMG_2hB MVK protein_coding protein_coding 24.58989 45.44305 9.25381 1.635612 0.1638865 -2.2947 1.3398828 2.044263 0.6320686 0.42479483 0.6320686 -1.6778217 0.06532500 0.04443333 0.0661000 0.02166667 0.4611466296 0.0008136789 FALSE FALSE
MSTRG.7987.10 ENSG00000110921 HEK293_OSMI2_2hA HEK293_TMG_2hB MVK protein_coding   24.58989 45.44305 9.25381 1.635612 0.1638865 -2.2947 1.7984551 2.396160 1.6489148 0.77173819 0.3867163 -0.5364927 0.09167083 0.05253333 0.1797333 0.12720000 0.0395098935 0.0008136789 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110921 E001 1.0779080 0.3096567586 3.799699e-01 5.242377e-01 12 109573255 109573301 47 + 0.417 0.212 -1.353
ENSG00000110921 E002 1.8507959 0.0124538018 6.971745e-01 7.973679e-01 12 109573302 109573340 39 + 0.416 0.340 -0.435
ENSG00000110921 E003 4.0951896 0.0161911731 8.471911e-01 9.050850e-01 12 109573341 109573546 206 + 0.532 0.576 0.200
ENSG00000110921 E004 7.1739674 0.0023729377 1.243520e-02 3.458375e-02 12 109573547 109573571 25 + 0.256 0.789 2.683
ENSG00000110921 E005 1.2533437 0.0316122205 3.269303e-01 4.703807e-01 12 109573793 109573793 1 + 0.416 0.221 -1.276
ENSG00000110921 E006 1.7650456 0.0082728795 6.040406e-01 7.246857e-01 12 109573794 109573804 11 + 0.416 0.313 -0.602
ENSG00000110921 E007 6.3174225 0.0029181171 4.084514e-01 5.520550e-01 12 109573805 109573813 9 + 0.820 0.695 -0.504
ENSG00000110921 E008 11.6974389 0.0015283427 3.453408e-01 4.894425e-01 12 109573814 109573831 18 + 1.026 0.910 -0.432
ENSG00000110921 E009 14.1643099 0.0012730302 3.808597e-01 5.251404e-01 12 109573832 109573836 5 + 1.087 0.988 -0.365
ENSG00000110921 E010 45.0873554 0.0020150229 2.717112e-01 4.104822e-01 12 109573837 109573873 37 + 1.540 1.464 -0.263
ENSG00000110921 E011 0.3332198 0.0289673529 1.890000e-01   12 109574807 109574808 2 + 0.256 0.054 -2.603
ENSG00000110921 E012 53.8626771 0.0005913524 2.364247e-01 3.700240e-01 12 109574809 109574817 9 + 1.614 1.540 -0.251
ENSG00000110921 E013 73.5892400 0.0003916166 3.010617e-01 4.428305e-01 12 109574818 109574829 12 + 1.732 1.678 -0.183
ENSG00000110921 E014 81.8952523 0.0004015452 6.037548e-01 7.244660e-01 12 109574830 109574836 7 + 1.751 1.728 -0.078
ENSG00000110921 E015 164.9461239 0.0025507715 3.861561e-01 5.303512e-01 12 109574837 109574900 64 + 2.060 2.028 -0.107
ENSG00000110921 E016 320.5866116 0.0014813695 9.368491e-02 1.808820e-01 12 109575998 109576145 148 + 2.359 2.313 -0.156
ENSG00000110921 E017 3.1601770 0.0162653626 6.689715e-01 7.758900e-01 12 109579165 109579282 118 + 0.416 0.510 0.478
ENSG00000110921 E018 0.3697384 0.0246752496 1.000000e+00 1.000000e+00 12 109579283 109579289 7 + 0.001 0.102 7.596
ENSG00000110921 E019 319.2276127 0.0002667659 8.761548e-02 1.715174e-01 12 109579802 109579946 145 + 2.352 2.310 -0.140
ENSG00000110921 E020 224.0814269 0.0024340802 4.311922e-02 9.676961e-02 12 109581395 109581478 84 + 2.225 2.152 -0.242
ENSG00000110921 E021 200.4961527 0.0067086939 2.695496e-01 4.080430e-01 12 109581479 109581550 72 + 2.160 2.109 -0.168
ENSG00000110921 E022 319.4470786 0.0031440746 5.565914e-01 6.851811e-01 12 109586022 109586125 104 + 2.288 2.320 0.105
ENSG00000110921 E023 218.5631064 0.0002261700 9.198357e-03 2.678082e-02 12 109586754 109586799 46 + 2.060 2.164 0.346
ENSG00000110921 E024 13.9322091 0.0014293757 1.558767e-01 2.696148e-01 12 109586800 109587099 300 + 1.141 0.981 -0.581
ENSG00000110921 E025 110.1683860 0.0003260735 5.134777e-21 3.711439e-19 12 109587861 109590682 2822 + 2.167 1.792 -1.261
ENSG00000110921 E026 14.6005826 0.0012362637 4.880155e-01 6.256425e-01 12 109590683 109590770 88 + 1.087 1.010 -0.281
ENSG00000110921 E027 288.0147885 0.0002315911 2.588037e-01 3.961250e-01 12 109590771 109590845 75 + 2.235 2.277 0.140
ENSG00000110921 E028 203.4327519 0.0001882909 3.773868e-01 5.217144e-01 12 109590846 109590861 16 + 2.087 2.126 0.131
ENSG00000110921 E029 365.4237621 0.0001968063 3.742199e-01 5.186379e-01 12 109591241 109591357 117 + 2.349 2.380 0.103
ENSG00000110921 E030 380.9511785 0.0005649459 3.602458e-02 8.363559e-02 12 109595028 109595181 154 + 2.334 2.402 0.226
ENSG00000110921 E031 919.7969303 0.0017518442 4.812462e-05 2.722980e-04 12 109596426 109598125 1700 + 2.683 2.788 0.349