ENSG00000110888

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298892 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding protein_coding 4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.05138708 0.16865103 0.0000000 0.09935218 0.00000000 -4.1590723 0.01362917 0.06756667 0.00000000 -0.06756667 3.374255e-02 1.222781e-05 FALSE TRUE
ENST00000454014 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding nonsense_mediated_decay 4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.69031926 0.00000000 1.0454136 0.00000000 0.17709910 6.7216647 0.13299583 0.00000000 0.15803333 0.15803333 1.222781e-05 1.222781e-05 FALSE TRUE
ENST00000537553 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding nonsense_mediated_decay 4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.54088740 0.17218622 0.7892988 0.02588076 0.05249087 2.1333211 0.11106667 0.08046667 0.11696667 0.03650000 5.285472e-01 1.222781e-05 TRUE TRUE
ENST00000543380 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding protein_coding 4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.14743775 0.00000000 0.3872063 0.00000000 0.15146487 5.3118165 0.02539167 0.00000000 0.05493333 0.05493333 2.907334e-02 1.222781e-05   FALSE
ENST00000548676 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding nonsense_mediated_decay 4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.81415523 1.05957917 1.4880806 0.23188652 0.11486729 0.4860719 0.20983333 0.47830000 0.21980000 -0.25850000 4.228987e-05 1.222781e-05 FALSE TRUE
ENST00000614865 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding retained_intron 4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.28296346 0.04120112 0.6615790 0.04120112 0.32922580 3.7133099 0.05804167 0.01443333 0.09246667 0.07803333 1.273393e-01 1.222781e-05   FALSE
ENST00000620681 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding processed_transcript 4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.45733615 0.02535145 0.4856624 0.02535145 0.07552843 3.8095164 0.09152500 0.01286667 0.07340000 0.06053333 3.202672e-02 1.222781e-05 FALSE TRUE
ENST00000686317 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding protein_coding 4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.38855807 0.15677519 0.3595301 0.07849272 0.23154267 1.1477873 0.09855000 0.08563333 0.05713333 -0.02850000 8.781509e-01 1.222781e-05 FALSE TRUE
MSTRG.7048.33 ENSG00000110888 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN2 protein_coding   4.569519 2.176706 6.789661 0.3488926 0.4233471 1.636704 0.13113428 0.00000000 0.4156610 0.00000000 0.14829370 5.4116330 0.02331250 0.00000000 0.06350000 0.06350000 2.249720e-02 1.222781e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110888 E001 0.0000000       12 30709552 30709552 1 -      
ENSG00000110888 E002 0.5869318 0.3092360808 0.5442769248 0.6747613444 12 30709553 30709553 1 - 0.160 0.283 1.045
ENSG00000110888 E003 2.7960163 0.0053953816 0.2050435263 0.3324564876 12 30709554 30709562 9 - 0.479 0.681 0.915
ENSG00000110888 E004 2.9443095 0.0051971211 0.1205220684 0.2207087829 12 30709563 30709563 1 - 0.479 0.721 1.084
ENSG00000110888 E005 3.3871999 0.0047646686 0.0374386335 0.0862882684 12 30709564 30709564 1 - 0.479 0.794 1.375
ENSG00000110888 E006 3.3871999 0.0047646686 0.0374386335 0.0862882684 12 30709565 30709566 2 - 0.479 0.794 1.375
ENSG00000110888 E007 3.3871999 0.0047646686 0.0374386335 0.0862882684 12 30709567 30709571 5 - 0.479 0.794 1.375
ENSG00000110888 E008 3.3871999 0.0047646686 0.0374386335 0.0862882684 12 30709572 30709573 2 - 0.479 0.794 1.375
ENSG00000110888 E009 4.0838153 0.0042971273 0.0092354818 0.0268752775 12 30709574 30709576 3 - 0.510 0.883 1.571
ENSG00000110888 E010 4.6352581 0.0036967148 0.0011829062 0.0045834380 12 30709577 30709581 5 - 0.510 0.957 1.851
ENSG00000110888 E011 4.9308003 0.0033068664 0.0010897870 0.0042693428 12 30709582 30709583 2 - 0.539 0.979 1.795
ENSG00000110888 E012 5.2211457 0.0049283376 0.0036194737 0.0120662073 12 30709584 30709587 4 - 0.592 0.979 1.555
ENSG00000110888 E013 8.5446594 0.0020639332 0.0035280660 0.0118069833 12 30709588 30709642 55 - 0.819 1.140 1.195
ENSG00000110888 E014 6.9633944 0.0024742133 0.0521585115 0.1130024533 12 30709643 30709651 9 - 0.788 1.020 0.883
ENSG00000110888 E015 10.8924706 0.0016102265 0.0001300082 0.0006588995 12 30709652 30709685 34 - 0.874 1.257 1.397
ENSG00000110888 E016 27.1930905 0.0170476346 0.0003105853 0.0014226173 12 30709686 30709782 97 - 1.291 1.609 1.097
ENSG00000110888 E017 30.9140224 0.0323619431 0.0136800639 0.0374948939 12 30709783 30709869 87 - 1.381 1.631 0.859
ENSG00000110888 E018 59.8112547 0.0013836019 0.0607330583 0.1278666366 12 30709870 30710208 339 - 1.725 1.817 0.311
ENSG00000110888 E019 14.8759761 0.0447648896 0.9206505650 0.9539290935 12 30710209 30710242 34 - 1.159 1.197 0.134
ENSG00000110888 E020 16.1901056 0.0079467420 0.5328847024 0.6651692893 12 30710243 30710270 28 - 1.185 1.247 0.221
ENSG00000110888 E021 24.7805931 0.0067461699 0.7873553867 0.8638165600 12 30710271 30710339 69 - 1.377 1.403 0.091
ENSG00000110888 E022 31.2666628 0.0013308952 0.0647908948 0.1347018936 12 30710340 30710470 131 - 1.437 1.558 0.412
ENSG00000110888 E023 4.4630090 0.0037994947 0.4311568802 0.5737421679 12 30710471 30710514 44 - 0.681 0.793 0.456
ENSG00000110888 E024 1.2437944 0.0893681134 0.7502574852 0.8369922489 12 30710515 30710546 32 - 0.326 0.383 0.345
ENSG00000110888 E025 21.3809076 0.0012496688 0.0003949923 0.0017552979 12 30711566 30711629 64 - 1.209 1.476 0.929
ENSG00000110888 E026 1.6648277 0.0737501810 0.4350748260 0.5773150035 12 30711739 30711782 44 - 0.369 0.523 0.799
ENSG00000110888 E027 28.3751769 0.0013678347 0.0105529101 0.0300982171 12 30713785 30713885 101 - 1.381 1.551 0.588
ENSG00000110888 E028 1.1082728 0.0145429116 0.3718182656 0.5162963136 12 30714927 30714958 32 - 0.223 0.385 1.089
ENSG00000110888 E029 32.6045324 0.0032856263 0.3655806240 0.5098922356 12 30714959 30715076 118 - 1.491 1.551 0.206
ENSG00000110888 E030 14.8635376 0.0105957766 0.9360173065 0.9637683740 12 30715077 30715081 5 - 1.185 1.194 0.033
ENSG00000110888 E031 20.0386075 0.0066911185 0.8090619776 0.8787105759 12 30715082 30715141 60 - 1.320 1.299 -0.074
ENSG00000110888 E032 10.0102123 0.0259626905 0.4101291602 0.5537458326 12 30715142 30715144 3 - 1.069 0.955 -0.417
ENSG00000110888 E033 9.8263073 0.0697646677 0.1273445841 0.2304383280 12 30715145 30715453 309 - 1.100 0.849 -0.934
ENSG00000110888 E034 4.6125524 0.0034781554 0.1432090429 0.2523887023 12 30715454 30715503 50 - 0.804 0.585 -0.916
ENSG00000110888 E035 11.0008665 0.0015299230 0.0032060315 0.0108734857 12 30715504 30715874 371 - 1.159 0.825 -1.238
ENSG00000110888 E036 7.0113722 0.1195792807 0.1732554360 0.2924329056 12 30715875 30715954 80 - 0.966 0.689 -1.083
ENSG00000110888 E037 10.4075920 0.0016124463 0.0011046661 0.0043186132 12 30715955 30716289 335 - 1.145 0.759 -1.452
ENSG00000110888 E038 7.5824258 0.0022488625 0.0128858054 0.0356490723 12 30716290 30716507 218 - 1.007 0.681 -1.273
ENSG00000110888 E039 25.4930207 0.0007886428 0.6148279945 0.7332211931 12 30716508 30716622 115 - 1.419 1.384 -0.121
ENSG00000110888 E040 16.9404899 0.0018684274 0.1147029090 0.2123990499 12 30716623 30716676 54 - 1.281 1.140 -0.500
ENSG00000110888 E041 19.6101473 0.0018755353 0.3643513751 0.5087262711 12 30719079 30719225 147 - 1.320 1.245 -0.261
ENSG00000110888 E042 8.1736925 0.1827286767 0.5573614863 0.6857859420 12 30719226 30719701 476 - 0.946 0.915 -0.118
ENSG00000110888 E043 2.7700672 0.1379431687 0.8032851265 0.8747609201 12 30719702 30719748 47 - 0.510 0.598 0.407
ENSG00000110888 E044 6.9314108 0.0285339199 0.2321090831 0.3649431864 12 30719749 30720810 1062 - 0.934 0.761 -0.672
ENSG00000110888 E045 10.3389487 0.0083831762 0.9740552947 0.9878050073 12 30720811 30720915 105 - 1.043 1.039 -0.015
ENSG00000110888 E046 16.6413075 0.0143778096 0.6198100481 0.7371205616 12 30723259 30723314 56 - 1.249 1.196 -0.188
ENSG00000110888 E047 18.8560709 0.0014076092 0.4935578984 0.6305648243 12 30724370 30724451 82 - 1.301 1.245 -0.196
ENSG00000110888 E048 11.9460531 0.0144518285 0.9872568541 0.9960946037 12 30725966 30725998 33 - 1.094 1.093 -0.002
ENSG00000110888 E049 18.1411102 0.0010571339 0.0611158064 0.1285110846 12 30725999 30726088 90 - 1.315 1.154 -0.568
ENSG00000110888 E050 0.0000000       12 30728379 30728647 269 -      
ENSG00000110888 E051 13.6602189 0.0012972886 0.0035242728 0.0117963729 12 30728648 30728667 20 - 1.233 0.934 -1.085
ENSG00000110888 E052 73.9192573 0.0029176474 0.0039098959 0.0128910207 12 30728668 30729325 658 - 1.901 1.760 -0.478
ENSG00000110888 E053 17.0346174 0.0051436909 0.4698721704 0.6091011753 12 30730239 30730282 44 - 1.260 1.196 -0.227
ENSG00000110888 E054 12.6219703 0.0160177947 0.4361419863 0.5782677739 12 30731343 30731359 17 - 1.145 1.059 -0.310
ENSG00000110888 E055 24.2199036 0.0068450556 0.5438775558 0.6744118715 12 30731360 30731469 110 - 1.400 1.350 -0.175
ENSG00000110888 E056 14.3664327 0.0041051263 0.6386481785 0.7522381340 12 30731470 30731510 41 - 1.185 1.140 -0.160
ENSG00000110888 E057 2.4012978 0.0513401400 0.1308419899 0.2353257437 12 30733629 30733659 31 - 0.409 0.678 1.268
ENSG00000110888 E058 3.1107004 0.0541147543 0.2176714933 0.3475932799 12 30733660 30733706 47 - 0.510 0.721 0.931
ENSG00000110888 E059 1.8991739 0.1605684470 0.8504962907 0.9072448903 12 30733707 30733711 5 - 0.446 0.460 0.072
ENSG00000110888 E060 0.1472490 0.0431556111 1.0000000000   12 30734955 30734967 13 - 0.088 0.000 -9.035
ENSG00000110888 E061 25.3435435 0.0160194520 0.4200376425 0.5632662151 12 30734968 30735206 239 - 1.420 1.354 -0.229
ENSG00000110888 E062 0.6653823 0.0170489010 0.7663329035 0.8488687141 12 30735881 30735973 93 - 0.223 0.169 -0.499
ENSG00000110888 E063 0.0000000       12 30740144 30740267 124 -      
ENSG00000110888 E064 0.0000000       12 30741016 30741019 4 -      
ENSG00000110888 E065 12.1346889 0.0850492164 0.6707881003 0.7771500146 12 30741020 30741106 87 - 1.116 1.055 -0.222
ENSG00000110888 E066 0.0000000       12 30747600 30747674 75 -      
ENSG00000110888 E067 10.1815300 0.0579967377 0.8655586177 0.9173976091 12 30751071 30751133 63 - 1.035 1.008 -0.096
ENSG00000110888 E068 2.0575731 0.0445583992 0.1565219293 0.2704765070 12 30751422 30751655 234 - 0.566 0.288 -1.507
ENSG00000110888 E069 0.3289534 0.0287229101 0.5824075465   12 30752475 30752593 119 - 0.088 0.169 1.085
ENSG00000110888 E070 14.4949869 0.0086175041 0.0028361418 0.0097824045 12 30753344 30753538 195 - 1.260 0.935 -1.178
ENSG00000110888 E071 4.7821536 0.0039962899 0.0034161989 0.0114859730 12 30753539 30753549 11 - 0.861 0.384 -2.137
ENSG00000110888 E072 4.3424829 0.0152649696 0.0110563686 0.0312985949 12 30753550 30753559 10 - 0.819 0.385 -1.972
ENSG00000110888 E073 4.4574666 0.0239413635 0.0020873259 0.0074944589 12 30753560 30753609 50 - 0.848 0.290 -2.667
ENSG00000110888 E074 14.2257595 0.0091910057 0.0070592100 0.0213794087 12 30753610 30754079 470 - 1.250 0.957 -1.057
ENSG00000110888 E075 6.1364473 0.0060112827 0.3885884342 0.5326646149 12 30754080 30754203 124 - 0.874 0.759 -0.451
ENSG00000110888 E076 7.0503579 0.0024172940 0.2649449935 0.4029523573 12 30754204 30754334 131 - 0.934 0.793 -0.544
ENSG00000110888 E077 4.8631424 0.0034066539 0.2476313549 0.3831604604 12 30754335 30754438 104 - 0.804 0.635 -0.693
ENSG00000110888 E078 2.4209568 0.0652103112 0.1087145034 0.2036369404 12 30754439 30754579 141 - 0.615 0.290 -1.719
ENSG00000110888 E079 1.0632359 0.0122693838 0.2859000436 0.4262681746 12 30754583 30754654 72 - 0.369 0.168 -1.500
ENSG00000110888 E080 0.9139106 0.0188041622 0.4043630352 0.5480828726 12 30754655 30754680 26 - 0.326 0.168 -1.237
ENSG00000110888 E081 1.6480794 0.0215845295 0.0780089734 0.1562711853 12 30754681 30754688 8 - 0.510 0.168 -2.236
ENSG00000110888 E082 2.5777959 0.0056451462 0.1840743463 0.3063437346 12 30754689 30754725 37 - 0.616 0.384 -1.138
ENSG00000110888 E083 2.5757196 0.0067443128 0.1857731335 0.3084717844 12 30754726 30754750 25 - 0.616 0.384 -1.138
ENSG00000110888 E084 4.1245960 0.0049839788 0.0425092493 0.0956467576 12 30754751 30754888 138 - 0.788 0.462 -1.439
ENSG00000110888 E085 1.0351233 0.0120906311 0.0397158991 0.0904964751 12 30754889 30754955 67 - 0.409 0.000 -11.594
ENSG00000110888 E086 0.0000000       12 30822982 30823302 321 -