ENSG00000110881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000228468 ENSG00000110881 HEK293_OSMI2_2hA HEK293_TMG_2hB ASIC1 protein_coding protein_coding 17.35921 22.76464 14.26837 0.819447 0.7506669 -0.6735963 1.081953 1.2770836 0.7917974 0.1769207 0.1871850 -0.6827961 0.0621625 0.05566667 0.0571 0.001433333 1.000000e+00 8.654368e-12 FALSE TRUE
ENST00000447966 ENSG00000110881 HEK293_OSMI2_2hA HEK293_TMG_2hB ASIC1 protein_coding protein_coding 17.35921 22.76464 14.26837 0.819447 0.7506669 -0.6735963 11.003969 15.3495046 9.6495669 1.7291693 0.1961872 -0.6691013 0.6327208 0.67063333 0.6814 0.010766667 9.845950e-01 8.654368e-12 FALSE TRUE
ENST00000548350 ENSG00000110881 HEK293_OSMI2_2hA HEK293_TMG_2hB ASIC1 protein_coding retained_intron 17.35921 22.76464 14.26837 0.819447 0.7506669 -0.6735963 1.407516 0.6214077 1.3286225 0.1642038 0.2406445 1.0841053 0.0869875 0.02686667 0.0919 0.065033333 1.188450e-03 8.654368e-12 FALSE TRUE
ENST00000552633 ENSG00000110881 HEK293_OSMI2_2hA HEK293_TMG_2hB ASIC1 protein_coding protein_coding 17.35921 22.76464 14.26837 0.819447 0.7506669 -0.6735963 1.091203 3.7724579 0.0000000 0.9443616 0.0000000 -8.5631802 0.0497250 0.16900000 0.0000 -0.169000000 8.654368e-12 8.654368e-12 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110881 E001 5.2080089 0.0187921832 3.662855e-01 5.106123e-01 12 50057548 50057595 48 + 0.820 0.722 -0.393
ENSG00000110881 E002 7.9881201 0.0028114713 2.483629e-02 6.153914e-02 12 50057596 50057616 21 + 1.057 0.834 -0.836
ENSG00000110881 E003 16.8705640 0.0069975109 3.181445e-07 2.928219e-06 12 50057617 50057744 128 + 1.450 1.024 -1.507
ENSG00000110881 E004 9.3067776 0.0018272987 9.016991e-13 2.231246e-11 12 50057745 50057790 46 + 1.322 0.562 -2.918
ENSG00000110881 E005 30.4309141 0.0248440734 1.914022e-02 4.964480e-02 12 50057791 50057916 126 + 1.582 1.399 -0.632
ENSG00000110881 E006 183.8759915 0.0043723866 6.275872e-03 1.933579e-02 12 50058751 50059128 378 + 2.288 2.219 -0.229
ENSG00000110881 E007 152.2942113 0.0082095462 2.946573e-02 7.090301e-02 12 50059759 50059886 128 + 2.205 2.138 -0.224
ENSG00000110881 E008 104.7030807 0.0136672876 1.567713e-01 2.707914e-01 12 50059887 50059954 68 + 2.030 1.985 -0.151
ENSG00000110881 E009 0.0000000       12 50070740 50070893 154 +      
ENSG00000110881 E010 0.1817044 0.0398670383 7.627474e-01   12 50073575 50074244 670 + 0.000 0.102 8.341
ENSG00000110881 E011 0.4847352 0.2223069209 3.824032e-01 5.266247e-01 12 50076750 50076967 218 + 0.256 0.102 -1.597
ENSG00000110881 E012 3.2673240 0.2493993551 8.892471e-01 9.332086e-01 12 50076968 50077049 82 + 0.626 0.614 -0.052
ENSG00000110881 E013 1.2199456 0.0110400482 6.099274e-01 7.293241e-01 12 50077050 50077060 11 + 0.255 0.366 0.726
ENSG00000110881 E014 126.2090394 0.0093189154 2.043180e-01 3.315594e-01 12 50077213 50077363 151 + 2.100 2.072 -0.095
ENSG00000110881 E015 127.0681039 0.0069866820 1.874703e-01 3.105442e-01 12 50078000 50078127 128 + 2.101 2.075 -0.088
ENSG00000110881 E016 8.0642112 0.0050030666 4.715720e-01 6.106778e-01 12 50078418 50078420 3 + 0.845 0.965 0.454
ENSG00000110881 E017 84.0573528 0.0029575154 8.972009e-02 1.747012e-01 12 50078421 50078461 41 + 1.930 1.888 -0.140
ENSG00000110881 E018 135.4986300 0.0002665526 5.716369e-02 1.217442e-01 12 50078462 50078577 116 + 2.124 2.101 -0.079
ENSG00000110881 E019 12.3943664 0.0077166915 4.455404e-05 2.541134e-04 12 50078578 50078923 346 + 1.306 0.926 -1.370
ENSG00000110881 E020 109.8068836 0.0002901687 3.278222e-03 1.108641e-02 12 50078924 50078980 57 + 2.061 1.996 -0.219
ENSG00000110881 E021 171.5721435 0.0007463087 1.015962e-03 4.013993e-03 12 50079902 50080055 154 + 2.251 2.191 -0.200
ENSG00000110881 E022 5.2611687 0.0274104836 4.323605e-02 9.698470e-02 12 50080361 50080497 137 + 0.935 0.671 -1.044
ENSG00000110881 E023 159.7933303 0.0002343564 1.160960e-01 2.143857e-01 12 50080498 50080589 92 + 2.187 2.178 -0.031
ENSG00000110881 E024 17.0446421 0.0010493833 2.013146e-01 3.278317e-01 12 50080590 50080727 138 + 1.279 1.207 -0.255
ENSG00000110881 E025 4.9397911 0.0954733598 4.908362e-02 1.075261e-01 12 50080728 50080782 55 + 0.936 0.597 -1.367
ENSG00000110881 E026 130.0723075 0.0002983068 1.975857e-01 3.231941e-01 12 50081102 50081181 80 + 2.096 2.090 -0.018
ENSG00000110881 E027 161.1747255 0.0002402200 8.550846e-01 9.103709e-01 12 50081260 50081364 105 + 2.165 2.196 0.103
ENSG00000110881 E028 172.3626820 0.0002730134 8.400773e-01 9.001297e-01 12 50081545 50081778 234 + 2.186 2.228 0.140
ENSG00000110881 E029 491.6975651 0.0026954244 5.684479e-05 3.157809e-04 12 50081779 50082715 937 + 2.569 2.719 0.498
ENSG00000110881 E030 490.7479164 0.0091175959 2.113337e-08 2.452618e-07 12 50082716 50083611 896 + 2.464 2.754 0.965