ENSG00000110880

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261401 ENSG00000110880 HEK293_OSMI2_2hA HEK293_TMG_2hB CORO1C protein_coding protein_coding 43.42406 29.42499 65.21198 4.634352 2.81466 1.147826 36.117949 28.82669 50.397462 4.745562 0.9380863 0.8057317 0.86738333 0.9777333 0.7750667 -0.2026667 2.980773e-07 3.741157e-30 FALSE TRUE
ENST00000421578 ENSG00000110880 HEK293_OSMI2_2hA HEK293_TMG_2hB CORO1C protein_coding protein_coding 43.42406 29.42499 65.21198 4.634352 2.81466 1.147826 3.826689 0.00000 9.001175 0.000000 0.6668803 9.8155715 0.06432083 0.0000000 0.1393000 0.1393000 3.741157e-30 3.741157e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110880 E001 3.5908509 0.0293504601 1.746975e-03 6.431012e-03 12 108645109 108645114 6 - 0.376 0.920 2.408
ENSG00000110880 E002 1335.3527251 0.0042911168 6.011580e-18 3.025706e-16 12 108645115 108646219 1105 - 2.979 3.272 0.974
ENSG00000110880 E003 551.3935478 0.0002000950 8.643678e-18 4.286699e-16 12 108646220 108646566 347 - 2.659 2.840 0.601
ENSG00000110880 E004 137.8947567 0.0002330158 6.764376e-04 2.812754e-03 12 108646567 108646568 2 - 2.075 2.222 0.493
ENSG00000110880 E005 265.9316418 0.0001678692 5.765100e-12 1.246924e-10 12 108646569 108646645 77 - 2.335 2.530 0.652
ENSG00000110880 E006 486.2666611 0.0007390864 3.247079e-19 1.896853e-17 12 108646646 108646988 343 - 2.582 2.802 0.731
ENSG00000110880 E007 509.5627484 0.0002070593 6.128796e-06 4.277491e-05 12 108646989 108647379 391 - 2.651 2.769 0.391
ENSG00000110880 E008 128.3656926 0.0002529814 1.963241e-01 3.216192e-01 12 108647380 108647383 4 - 2.102 2.103 0.002
ENSG00000110880 E009 165.6784724 0.0002255822 3.302102e-01 4.737936e-01 12 108647384 108647400 17 - 2.185 2.256 0.235
ENSG00000110880 E010 149.9719436 0.0002377472 5.483907e-01 6.782424e-01 12 108647401 108647402 2 - 2.146 2.207 0.203
ENSG00000110880 E011 348.3705076 0.0001366039 3.461959e-02 8.093711e-02 12 108647403 108647522 120 - 2.534 2.535 0.003
ENSG00000110880 E012 301.2012084 0.0001579376 6.542413e-03 2.003427e-02 12 108648605 108648686 82 - 2.477 2.462 -0.051
ENSG00000110880 E013 374.0563758 0.0001489409 1.567651e-03 5.854262e-03 12 108648687 108648850 164 - 2.573 2.554 -0.061
ENSG00000110880 E014 129.5420330 0.0004090115 8.825219e-02 1.724527e-01 12 108648963 108648966 4 - 2.113 2.100 -0.046
ENSG00000110880 E015 222.3109393 0.0002238626 1.070498e-02 3.046456e-02 12 108648967 108649020 54 - 2.348 2.326 -0.072
ENSG00000110880 E016 5.2583680 0.0034178326 2.377046e-02 5.934456e-02 12 108649021 108649671 651 - 0.871 0.576 -1.217
ENSG00000110880 E017 2.4993202 0.0194052355 3.151302e-02 7.490555e-02 12 108652045 108652271 227 - 0.648 0.283 -1.904
ENSG00000110880 E018 348.2540907 0.0007011627 2.010185e-04 9.680807e-04 12 108652272 108652417 146 - 2.550 2.503 -0.157
ENSG00000110880 E019 0.4482035 0.0293281704 2.355580e-01 3.690306e-01 12 108653038 108653060 23 - 0.228 0.000 -11.509
ENSG00000110880 E020 309.2898301 0.0018051842 9.788332e-05 5.121013e-04 12 108654306 108654410 105 - 2.509 2.430 -0.263
ENSG00000110880 E021 228.6048690 0.0003199067 2.199998e-03 7.841784e-03 12 108657304 108657361 58 - 2.365 2.329 -0.119
ENSG00000110880 E022 246.5313232 0.0008592387 5.584113e-04 2.378893e-03 12 108657362 108657423 62 - 2.404 2.351 -0.178
ENSG00000110880 E023 302.6422436 0.0002006004 2.152346e-08 2.494070e-07 12 108658738 108658822 85 - 2.502 2.422 -0.267
ENSG00000110880 E024 229.1794889 0.0002409223 5.502725e-12 1.194540e-10 12 108658823 108658858 36 - 2.398 2.266 -0.443
ENSG00000110880 E025 185.0550881 0.0001999873 1.410881e-11 2.866657e-10 12 108658859 108658877 19 - 2.311 2.165 -0.489
ENSG00000110880 E026 171.0639230 0.0002155756 2.599604e-13 6.969816e-12 12 108658878 108658880 3 - 2.284 2.112 -0.575
ENSG00000110880 E027 219.0955511 0.0002000856 5.923101e-15 2.016739e-13 12 108658881 108658919 39 - 2.387 2.227 -0.535
ENSG00000110880 E028 0.4783925 0.0217681645 1.000000e+00 1.000000e+00 12 108662023 108662028 6 - 0.164 0.165 0.006
ENSG00000110880 E029 271.3553755 0.0004688797 1.349622e-16 5.717395e-15 12 108662029 108662113 85 - 2.480 2.314 -0.553
ENSG00000110880 E030 202.6633906 0.0020906506 1.071051e-07 1.082173e-06 12 108662114 108662158 45 - 2.348 2.200 -0.496
ENSG00000110880 E031 300.5174107 0.0009761693 2.527773e-13 6.788757e-12 12 108678272 108678394 123 - 2.521 2.368 -0.508
ENSG00000110880 E032 0.0000000       12 108696360 108696402 43 -      
ENSG00000110880 E033 0.2214452 0.0528838002 2.647996e-01   12 108700940 108701123 184 - 0.000 0.165 11.666
ENSG00000110880 E034 328.9675422 0.0001469009 6.739161e-28 9.457139e-26 12 108701124 108701306 183 - 2.571 2.379 -0.641
ENSG00000110880 E035 133.6300517 0.0002699864 1.774342e-10 3.000480e-09 12 108701307 108701323 17 - 2.175 2.004 -0.571
ENSG00000110880 E036 0.7480121 0.0980910291 4.854701e-01 6.233453e-01 12 108701324 108701356 33 - 0.283 0.164 -1.005
ENSG00000110880 E037 0.8921407 0.0132979532 4.572168e-02 1.015217e-01 12 108701489 108701965 477 - 0.376 0.000 -12.509
ENSG00000110880 E038 0.1451727 0.0435876828 1.000000e+00   12 108701966 108701981 16 - 0.090 0.000 -9.923
ENSG00000110880 E039 0.0000000       12 108702796 108703075 280 -      
ENSG00000110880 E040 2.8420998 0.0082484129 3.339129e-01 4.776821e-01 12 108730145 108730561 417 - 0.487 0.671 0.837
ENSG00000110880 E041 0.4428904 0.6978718311 1.962331e-01 3.215180e-01 12 108730562 108730622 61 - 0.000 0.299 12.764
ENSG00000110880 E042 0.5880631 0.4981010141 3.818727e-01 5.261352e-01 12 108730623 108730843 221 - 0.090 0.296 2.091
ENSG00000110880 E043 0.3729606 0.0278498322 6.547064e-01 7.648091e-01 12 108731102 108731153 52 - 0.090 0.165 1.008
ENSG00000110880 E044 137.5312210 0.0032467712 2.860641e-06 2.150640e-05 12 108731429 108731526 98 - 2.185 2.017 -0.561