ENSG00000110851

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000228437 ENSG00000110851 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM4 protein_coding protein_coding 20.82684 16.52314 25.07218 0.5702694 0.6635714 0.6013023 14.9502786 14.6662979 15.969567 1.187316633 0.3385376 0.1227402 0.74254167 0.884866667 0.63713333 -0.24773333 1.460811e-02 8.01303e-06 FALSE TRUE
ENST00000549416 ENSG00000110851 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM4 protein_coding retained_intron 20.82684 16.52314 25.07218 0.5702694 0.6635714 0.6013023 0.7505087 0.1309518 1.532735 0.007402049 0.3324684 3.4522163 0.03500833 0.007966667 0.06093333 0.05296667 8.013030e-06 8.01303e-06   FALSE
ENST00000550659 ENSG00000110851 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM4 protein_coding protein_coding 20.82684 16.52314 25.07218 0.5702694 0.6635714 0.6013023 1.3234301 0.5223154 1.814810 0.105089612 0.2875950 1.7773931 0.05797917 0.032100000 0.07190000 0.03980000 5.627470e-02 8.01303e-06 FALSE TRUE
MSTRG.7957.2 ENSG00000110851 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM4 protein_coding   20.82684 16.52314 25.07218 0.5702694 0.6635714 0.6013023 3.2203710 0.9645044 4.754791 0.562116116 0.4852929 2.2896723 0.13779583 0.060700000 0.19073333 0.13003333 4.120043e-01 8.01303e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110851 E001 267.3064282 0.0126484593 1.620385e-04 8.007332e-04 12 107732871 107733333 463 - 2.294 2.536 0.808
ENSG00000110851 E002 554.9917107 0.0028280029 9.029906e-05 4.764353e-04 12 107733334 107734190 857 - 2.681 2.805 0.412
ENSG00000110851 E003 307.2751302 0.0006978763 1.326683e-01 2.378094e-01 12 107734191 107734522 332 - 2.463 2.517 0.179
ENSG00000110851 E004 194.8110581 0.0002122187 7.216058e-02 1.469326e-01 12 107739383 107739551 169 - 2.261 2.326 0.218
ENSG00000110851 E005 160.6034074 0.0002634841 6.667747e-01 7.741715e-01 12 107740946 107741065 120 - 2.194 2.226 0.106
ENSG00000110851 E006 201.7636683 0.0007360673 7.518034e-01 8.381694e-01 12 107741066 107741260 195 - 2.295 2.323 0.092
ENSG00000110851 E007 105.8922280 0.0002996837 5.240048e-01 6.576294e-01 12 107742221 107742248 28 - 2.008 2.050 0.139
ENSG00000110851 E008 165.4450521 0.0002199077 7.235321e-01 8.173347e-01 12 107742249 107742348 100 - 2.209 2.239 0.098
ENSG00000110851 E009 5.9850231 0.0048962753 1.631679e-05 1.032695e-04 12 107742349 107742593 245 - 1.039 0.449 -2.457
ENSG00000110851 E010 134.6935265 0.0002695469 9.887961e-01 9.970316e-01 12 107743197 107743282 86 - 2.126 2.145 0.065
ENSG00000110851 E011 163.0415217 0.0003195761 1.819401e-01 3.036423e-01 12 107744543 107744661 119 - 2.186 2.242 0.189
ENSG00000110851 E012 6.3362614 0.0033165156 4.511795e-02 1.004142e-01 12 107744662 107744682 21 - 0.963 0.728 -0.915
ENSG00000110851 E013 193.5740997 0.0036599988 6.098110e-01 7.292165e-01 12 107746275 107746424 150 - 2.291 2.287 -0.013
ENSG00000110851 E014 227.7260443 0.0049582303 4.130063e-01 5.565476e-01 12 107751415 107751646 232 - 2.368 2.351 -0.057
ENSG00000110851 E015 379.9355612 0.0001538690 4.128112e-10 6.566952e-09 12 107751647 107752209 563 - 2.625 2.532 -0.309
ENSG00000110851 E016 123.0410985 0.0035033432 7.630958e-04 3.125756e-03 12 107753924 107754025 102 - 2.150 2.023 -0.425
ENSG00000110851 E017 64.9687224 0.0124449146 1.281494e-01 2.315807e-01 12 107754026 107754027 2 - 1.861 1.768 -0.313
ENSG00000110851 E018 111.0559026 0.0026465587 1.504783e-04 7.490975e-04 12 107754028 107754109 82 - 2.111 1.971 -0.470
ENSG00000110851 E019 0.2987644 0.0271240741 2.528592e-01   12 107754829 107754860 32 - 0.200 0.000 -9.269
ENSG00000110851 E020 113.2901318 0.0030578285 2.006165e-06 1.560189e-05 12 107756832 107756965 134 - 2.139 1.953 -0.621
ENSG00000110851 E021 109.5194669 0.0069043739 1.268704e-04 6.450504e-04 12 107760505 107760771 267 - 2.125 1.938 -0.627
ENSG00000110851 E022 1.5802339 0.0098201428 2.123301e-01 3.412828e-01 12 107760772 107760928 157 - 0.274 0.502 1.309
ENSG00000110851 E023 29.7185774 0.0111373455 5.106366e-03 1.621960e-02 12 107760957 107761130 174 - 1.582 1.369 -0.731
ENSG00000110851 E024 3.4147489 0.1240597494 9.560612e-01 9.764777e-01 12 107761131 107761274 144 - 0.626 0.638 0.049