ENSG00000110841

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537261 ENSG00000110841 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIBP1 protein_coding protein_coding 5.613841 2.647114 6.944297 0.01909519 0.7461585 1.388045 0.4035453 0.0000000 0.8609194 0.0000000 0.4913772 6.4444673 0.05669583 0.0000000 0.11376667 0.11376667 0.3005984167 0.0002119492 FALSE FALSE
ENST00000539326 ENSG00000110841 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIBP1 protein_coding protein_coding 5.613841 2.647114 6.944297 0.01909519 0.7461585 1.388045 0.3140381 0.8755053 0.0159982 0.4394264 0.0159982 -5.0900171 0.11448333 0.3319667 0.00190000 -0.33006667 0.1178254859 0.0002119492 FALSE TRUE
ENST00000540114 ENSG00000110841 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIBP1 protein_coding protein_coding 5.613841 2.647114 6.944297 0.01909519 0.7461585 1.388045 0.2279328 0.0000000 0.4020127 0.0000000 0.2013202 5.3646168 0.02691667 0.0000000 0.05660000 0.05660000 0.3302552513 0.0002119492 FALSE TRUE
ENST00000542629 ENSG00000110841 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIBP1 protein_coding protein_coding 5.613841 2.647114 6.944297 0.01909519 0.7461585 1.388045 1.0167798 0.4218379 1.4867030 0.4218379 0.1113758 1.7932261 0.17537917 0.1584333 0.22180000 0.06336667 0.3535088149 0.0002119492 FALSE TRUE
ENST00000545381 ENSG00000110841 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIBP1 protein_coding non_stop_decay 5.613841 2.647114 6.944297 0.01909519 0.7461585 1.388045 0.8021125 0.0000000 0.8995534 0.0000000 0.3609003 6.5070864 0.09139167 0.0000000 0.12216667 0.12216667 0.0002119492 0.0002119492 FALSE TRUE
MSTRG.7005.3 ENSG00000110841 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIBP1 protein_coding   5.613841 2.647114 6.944297 0.01909519 0.7461585 1.388045 0.9213619 0.4274294 1.9575164 0.2913232 0.2479865 2.1692536 0.14677917 0.1602000 0.28160000 0.12140000 0.5611011012 0.0002119492 FALSE TRUE
MSTRG.7005.4 ENSG00000110841 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIBP1 protein_coding   5.613841 2.647114 6.944297 0.01909519 0.7461585 1.388045 1.1947329 0.6946029 0.3731056 0.3477522 0.3731056 -0.8790681 0.24888750 0.2634667 0.05903333 -0.20443333 0.4122220059 0.0002119492 FALSE TRUE
MSTRG.7005.8 ENSG00000110841 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIBP1 protein_coding   5.613841 2.647114 6.944297 0.01909519 0.7461585 1.388045 0.2673932 0.1401853 0.2265191 0.1120268 0.1162766 0.6552131 0.05654583 0.0527000 0.03276667 -0.01993333 0.9941964007 0.0002119492 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110841 E001 0.0000000       12 27523431 27523707 277 +      
ENSG00000110841 E002 0.0000000       12 27524142 27524145 4 +      
ENSG00000110841 E003 0.4418608 0.0245770475 2.947553e-01 4.358657e-01 12 27524146 27524154 9 + 0.205 0.000 -11.585
ENSG00000110841 E004 0.7353267 0.0810918307 6.135742e-01 7.322356e-01 12 27524155 27524157 3 + 0.256 0.183 -0.611
ENSG00000110841 E005 1.5479581 0.0091320969 4.363484e-01 5.784337e-01 12 27524158 27524172 15 + 0.416 0.313 -0.605
ENSG00000110841 E006 1.5479581 0.0091320969 4.363484e-01 5.784337e-01 12 27524173 27524173 1 + 0.416 0.313 -0.605
ENSG00000110841 E007 1.5479581 0.0091320969 4.363484e-01 5.784337e-01 12 27524174 27524178 5 + 0.416 0.313 -0.605
ENSG00000110841 E008 1.9886730 0.0077916311 5.278698e-01 6.608267e-01 12 27524179 27524181 3 + 0.478 0.412 -0.342
ENSG00000110841 E009 3.9730781 0.0054337471 7.417329e-01 8.307758e-01 12 27524182 27524205 24 + 0.664 0.672 0.034
ENSG00000110841 E010 4.7115252 0.0038877053 8.999395e-01 9.401567e-01 12 27524206 27524219 14 + 0.717 0.760 0.173
ENSG00000110841 E011 4.8932296 0.0034637577 8.895131e-01 9.333771e-01 12 27524220 27524223 4 + 0.717 0.798 0.325
ENSG00000110841 E012 10.9621672 0.0016232390 1.119272e-01 2.083941e-01 12 27524224 27524365 142 + 1.080 0.975 -0.386
ENSG00000110841 E013 0.0000000       12 27538123 27538299 177 +      
ENSG00000110841 E014 11.6434562 0.0137112922 2.367780e-01 3.704579e-01 12 27578152 27578239 88 + 1.095 1.021 -0.269
ENSG00000110841 E015 0.0000000       12 27584125 27584418 294 +      
ENSG00000110841 E016 0.0000000       12 27599348 27599479 132 +      
ENSG00000110841 E017 14.1046270 0.0012477074 5.390014e-01 6.703229e-01 12 27633362 27633460 99 + 1.141 1.152 0.040
ENSG00000110841 E018 30.6811601 0.0006906529 7.108789e-03 2.150721e-02 12 27634910 27635115 206 + 1.498 1.384 -0.393
ENSG00000110841 E019 0.5870335 0.1006138942 2.028550e-01 3.298000e-01 12 27635116 27637319 2204 + 0.256 0.000 -11.995
ENSG00000110841 E020 28.3217962 0.0007135102 1.303057e-04 6.601425e-04 12 27646062 27646148 87 + 1.490 1.278 -0.736
ENSG00000110841 E021 24.1558711 0.0049296129 2.611095e-02 6.417042e-02 12 27647729 27647842 114 + 1.403 1.290 -0.393
ENSG00000110841 E022 0.2955422 0.0298964401 5.612079e-01   12 27647843 27647977 135 + 0.079 0.184 1.393
ENSG00000110841 E023 21.2536963 0.0198260647 2.586582e-03 9.024810e-03 12 27650010 27650141 132 + 1.385 1.119 -0.935
ENSG00000110841 E024 0.0000000       12 27654386 27654721 336 +      
ENSG00000110841 E025 25.6561090 0.0008445362 8.178020e-03 2.423434e-02 12 27654722 27654814 93 + 1.429 1.301 -0.446
ENSG00000110841 E026 0.0000000       12 27655143 27655235 93 +      
ENSG00000110841 E027 30.9097566 0.0065931467 8.905372e-01 9.340841e-01 12 27656616 27656730 115 + 1.448 1.509 0.209
ENSG00000110841 E028 0.0000000       12 27656731 27657123 393 +      
ENSG00000110841 E029 0.6717251 0.0308677842 8.015041e-01 8.735264e-01 12 27658816 27658848 33 + 0.205 0.184 -0.187
ENSG00000110841 E030 21.0631247 0.0094945739 5.320333e-01 6.644075e-01 12 27660884 27660933 50 + 1.261 1.387 0.440
ENSG00000110841 E031 14.7261092 0.0017755258 2.672306e-01 4.055306e-01 12 27660934 27660945 12 + 1.095 1.266 0.609
ENSG00000110841 E032 21.4880388 0.0113919901 5.535475e-01 6.826627e-01 12 27664362 27664437 76 + 1.311 1.326 0.056
ENSG00000110841 E033 6.8831528 0.0025748443 1.768142e-02 4.644932e-02 12 27664438 27664446 9 + 0.936 0.672 -1.045
ENSG00000110841 E034 32.7996378 0.0007272823 1.036205e-01 1.960099e-01 12 27667166 27667320 155 + 1.504 1.470 -0.116
ENSG00000110841 E035 30.4304800 0.0007385742 2.281945e-02 5.736718e-02 12 27671431 27671546 116 + 1.487 1.403 -0.290
ENSG00000110841 E036 19.9362128 0.0009817668 3.453478e-02 8.077861e-02 12 27672427 27672483 57 + 1.319 1.212 -0.376
ENSG00000110841 E037 16.8740415 0.0207455213 6.868990e-01 7.893374e-01 12 27673767 27673827 61 + 1.210 1.242 0.111
ENSG00000110841 E038 13.1345129 0.0906548805 9.945649e-01 1.000000e+00 12 27674192 27674221 30 + 1.086 1.187 0.361
ENSG00000110841 E039 26.8249484 0.0369592786 2.007481e-01 3.271326e-01 12 27676428 27676599 172 + 1.429 1.378 -0.178
ENSG00000110841 E040 2.7732168 0.0054019252 7.615753e-01 8.453980e-01 12 27676600 27677063 464 + 0.557 0.561 0.016
ENSG00000110841 E041 6.5870564 0.0032496596 8.220690e-02 1.629868e-01 12 27677064 27677096 33 + 0.893 0.718 -0.691
ENSG00000110841 E042 4.7681213 0.0060607290 4.832511e-02 1.062033e-01 12 27677097 27677992 896 + 0.807 0.561 -1.040
ENSG00000110841 E043 26.9563469 0.0258930350 6.853378e-02 1.409383e-01 12 27679489 27679639 151 + 1.445 1.345 -0.347
ENSG00000110841 E044 0.1515154 0.0429878592 1.000000e+00   12 27679800 27679932 133 + 0.079 0.000 -9.997
ENSG00000110841 E045 29.7229898 0.0007372274 1.351013e-01 2.412313e-01 12 27679933 27680061 129 + 1.467 1.438 -0.101
ENSG00000110841 E046 33.5481760 0.0006705222 4.054013e-01 5.490843e-01 12 27681546 27681696 151 + 1.501 1.521 0.069
ENSG00000110841 E047 28.4118424 0.0032333689 5.008209e-01 6.370330e-01 12 27682387 27682498 112 + 1.430 1.454 0.084
ENSG00000110841 E048 17.2035525 0.0306303177 9.611377e-01 9.795343e-01 12 27682615 27682623 9 + 1.201 1.280 0.278
ENSG00000110841 E049 25.5247627 0.0028871293 3.696801e-01 5.140771e-01 12 27682624 27682703 80 + 1.389 1.394 0.018
ENSG00000110841 E050 25.9019938 0.0015351829 1.047723e-01 1.977701e-01 12 27687385 27687507 123 + 1.413 1.365 -0.167
ENSG00000110841 E051 0.0000000       12 27688189 27688297 109 +      
ENSG00000110841 E052 28.5339360 0.0007547106 2.845776e-01 4.248212e-01 12 27688298 27688423 126 + 1.439 1.438 -0.005
ENSG00000110841 E053 41.0221696 0.0006290700 4.513472e-01 5.923094e-01 12 27689015 27689203 189 + 1.579 1.609 0.101
ENSG00000110841 E054 48.4590662 0.0007213263 2.954075e-01 4.365405e-01 12 27691749 27691928 180 + 1.655 1.671 0.057
ENSG00000110841 E055 28.6310240 0.0071104631 4.166124e-01 5.599850e-01 12 27692591 27692656 66 + 1.389 1.523 0.461
ENSG00000110841 E056 219.2723537 0.0184958321 8.335672e-09 1.042493e-07 12 27692796 27695564 2769 + 2.144 2.540 1.320