ENSG00000110768

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265963 ENSG00000110768 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H1 protein_coding protein_coding 18.24588 5.327579 31.3143 0.3755183 0.8048865 2.553025 6.9693459 3.40250742 9.78754822 0.34636675 0.76674296 1.521589 0.45295417 0.63670000 0.311800000 -0.32490000 5.568753e-09 5.568753e-09 FALSE TRUE
ENST00000418116 ENSG00000110768 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H1 protein_coding retained_intron 18.24588 5.327579 31.3143 0.3755183 0.8048865 2.553025 1.5967039 0.00000000 2.40385543 0.00000000 1.21637047 7.915195 0.06080000 0.00000000 0.078233333 0.07823333 3.865210e-01 5.568753e-09 FALSE TRUE
ENST00000453096 ENSG00000110768 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H1 protein_coding protein_coding 18.24588 5.327579 31.3143 0.3755183 0.8048865 2.553025 1.4850374 0.38161861 3.12386530 0.13228748 0.13060228 3.000422 0.07991250 0.07410000 0.099933333 0.02583333 6.095651e-01 5.568753e-09 FALSE TRUE
ENST00000524753 ENSG00000110768 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H1 protein_coding protein_coding 18.24588 5.327579 31.3143 0.3755183 0.8048865 2.553025 1.0730863 0.44598106 2.10409292 0.10982474 0.27834692 2.212993 0.06067917 0.08176667 0.066933333 -0.01483333 7.096866e-01 5.568753e-09 FALSE TRUE
ENST00000526630 ENSG00000110768 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H1 protein_coding protein_coding 18.24588 5.327579 31.3143 0.3755183 0.8048865 2.553025 1.0349237 0.05038615 1.57022847 0.05038615 0.31065914 4.709772 0.07265833 0.01006667 0.050733333 0.04066667 1.416685e-01 5.568753e-09 FALSE TRUE
MSTRG.5244.4 ENSG00000110768 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H1 protein_coding   18.24588 5.327579 31.3143 0.3755183 0.8048865 2.553025 0.1121617 0.37761350 0.09932247 0.20498802 0.09932247 -1.826029 0.01551250 0.07136667 0.003033333 -0.06833333 2.394008e-01 5.568753e-09 FALSE TRUE
MSTRG.5244.5 ENSG00000110768 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H1 protein_coding   18.24588 5.327579 31.3143 0.3755183 0.8048865 2.553025 4.8568803 0.41831742 9.81513486 0.23797888 1.09655209 4.519725 0.18684167 0.07856667 0.313000000 0.23443333 1.360627e-01 5.568753e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110768 E001 24.2353780 0.0080004300 8.930797e-02 1.740812e-01 11 18322295 18322546 252 + 1.347 1.190 -0.553
ENSG00000110768 E002 9.2263405 0.0018654742 1.328215e-01 2.380385e-01 11 18322547 18322556 10 + 0.962 0.765 -0.758
ENSG00000110768 E003 8.0169023 0.0020851631 1.998803e-02 5.146054e-02 11 18322557 18322557 1 + 0.931 0.574 -1.453
ENSG00000110768 E004 13.3471496 0.0013441573 1.199357e-01 2.198880e-01 11 18322558 18322566 9 + 1.104 0.933 -0.627
ENSG00000110768 E005 12.1668536 0.0013750962 2.436124e-01 3.784224e-01 11 18322567 18322567 1 + 1.059 0.933 -0.466
ENSG00000110768 E006 12.3141026 0.0013717796 2.238908e-01 3.550598e-01 11 18322568 18322568 1 + 1.065 0.933 -0.487
ENSG00000110768 E007 20.9447881 0.0009338544 2.005311e-01 3.268662e-01 11 18322569 18322581 13 + 1.275 1.169 -0.374
ENSG00000110768 E008 80.2744513 0.0003728667 5.438355e-04 2.323905e-03 11 18322582 18322740 159 + 1.854 1.692 -0.549
ENSG00000110768 E009 3.2262159 0.1045899822 9.211494e-02 1.784185e-01 11 18324236 18324296 61 + 0.625 0.226 -2.234
ENSG00000110768 E010 3.5848066 0.0043238701 1.486932e-01 2.599068e-01 11 18325947 18326019 73 + 0.642 0.376 -1.298
ENSG00000110768 E011 4.1717263 0.0040829428 7.814614e-02 1.564880e-01 11 18326020 18326153 134 + 0.699 0.376 -1.539
ENSG00000110768 E012 0.9286724 0.0151585700 9.151301e-01 9.502744e-01 11 18332662 18333059 398 + 0.248 0.227 -0.161
ENSG00000110768 E013 119.3213460 0.0002773645 2.455079e-06 1.873242e-05 11 18333060 18333228 169 + 2.029 1.844 -0.621
ENSG00000110768 E014 1.5812675 0.0088934539 1.273165e-01 2.303964e-01 11 18333229 18333609 381 + 0.284 0.574 1.576
ENSG00000110768 E015 137.8442487 0.0002732690 2.382571e-03 8.405732e-03 11 18335754 18335946 193 + 2.077 1.979 -0.330
ENSG00000110768 E016 61.2950878 0.0004109607 6.208265e-01 7.378909e-01 11 18338109 18338139 31 + 1.713 1.704 -0.031
ENSG00000110768 E017 79.7720288 0.0003178253 9.618488e-01 9.799279e-01 11 18338140 18338216 77 + 1.819 1.840 0.069
ENSG00000110768 E018 58.7174344 0.0004076875 3.695005e-01 5.139141e-01 11 18338217 18338274 58 + 1.700 1.667 -0.112
ENSG00000110768 E019 88.2628572 0.0003484131 3.660810e-03 1.218450e-02 11 18339564 18339657 94 + 1.888 1.764 -0.418
ENSG00000110768 E020 123.6262381 0.0002475655 1.047796e-01 1.977778e-01 11 18341261 18341408 148 + 2.019 1.973 -0.154
ENSG00000110768 E021 58.5021077 0.0005272665 5.588174e-01 6.870085e-01 11 18341409 18341410 2 + 1.676 1.727 0.171
ENSG00000110768 E022 0.1817044 0.0431262760 9.650467e-02   11 18341411 18341527 117 + 0.000 0.228 11.748
ENSG00000110768 E023 95.4966684 0.0017052642 4.283485e-01 5.711404e-01 11 18341528 18341607 80 + 1.901 1.881 -0.067
ENSG00000110768 E024 4.0992798 0.0756278235 3.697402e-01 5.141387e-01 11 18341608 18341958 351 + 0.673 0.485 -0.848
ENSG00000110768 E025 0.3697384 0.0274424043 1.765709e-02 4.639825e-02 11 18347104 18347587 484 + 0.000 0.376 12.748
ENSG00000110768 E026 108.6747176 0.0002933937 7.593952e-02 1.530138e-01 11 18347588 18347715 128 + 1.965 1.908 -0.193
ENSG00000110768 E027 107.2866792 0.0007845161 3.865754e-01 5.307514e-01 11 18347832 18347919 88 + 1.953 1.933 -0.066
ENSG00000110768 E028 30.5426942 0.0169793544 6.270171e-01 7.428900e-01 11 18347920 18348831 912 + 1.404 1.471 0.233
ENSG00000110768 E029 4.9345003 0.0153468317 1.302606e-01 2.345256e-01 11 18351572 18351880 309 + 0.750 0.486 -1.164
ENSG00000110768 E030 101.4608156 0.0003104168 7.012854e-01 8.005134e-01 11 18351881 18351969 89 + 1.924 1.926 0.006
ENSG00000110768 E031 0.0000000       11 18352018 18352097 80 +      
ENSG00000110768 E032 0.0000000       11 18352098 18352328 231 +      
ENSG00000110768 E033 119.6253155 0.0002425934 3.969620e-01 5.407349e-01 11 18352329 18352446 118 + 1.984 2.035 0.170
ENSG00000110768 E034 106.9969802 0.0003991207 3.517656e-01 4.959911e-01 11 18357952 18358042 91 + 1.935 1.991 0.190
ENSG00000110768 E035 0.5975289 0.0303904154 4.594645e-01 5.996223e-01 11 18358043 18358102 60 + 0.208 0.000 -9.700
ENSG00000110768 E036 122.1539544 0.0010612147 1.046807e-01 1.976366e-01 11 18358525 18358640 116 + 1.985 2.067 0.276
ENSG00000110768 E037 0.0000000       11 18358641 18358642 2 +      
ENSG00000110768 E038 116.6297795 0.0046004516 2.711700e-01 4.098770e-01 11 18360615 18360707 93 + 1.968 2.039 0.238
ENSG00000110768 E039 0.0000000       11 18360708 18360770 63 +      
ENSG00000110768 E040 204.9942817 0.0018517666 6.340835e-05 3.481184e-04 11 18365783 18366068 286 + 2.191 2.343 0.505
ENSG00000110768 E041 191.1381593 0.0055282758 5.637055e-08 6.004966e-07 11 18366069 18367045 977 + 2.132 2.386 0.850
ENSG00000110768 E042 1.9625600 0.0221509760 3.400123e-02 7.976313e-02 11 18367301 18367419 119 + 0.317 0.708 1.930