ENSG00000110756

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349215 ENSG00000110756 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS5 protein_coding protein_coding 7.231863 2.886106 11.65518 0.2892096 0.1337553 2.010022 0.9683258 0.45872003 1.3659342 0.11109398 0.4472016 1.5536132 0.14357917 0.16460000 0.11786667 -0.04673333 0.75985170 0.02609754 FALSE TRUE
ENST00000396253 ENSG00000110756 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS5 protein_coding protein_coding 7.231863 2.886106 11.65518 0.2892096 0.1337553 2.010022 1.4580257 0.90793763 1.6831475 0.36829760 0.6447032 0.8832396 0.24338333 0.29596667 0.14446667 -0.15150000 0.44250329 0.02609754 FALSE TRUE
ENST00000438420 ENSG00000110756 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS5 protein_coding protein_coding 7.231863 2.886106 11.65518 0.2892096 0.1337553 2.010022 2.0791250 0.75219384 3.3385866 0.29307606 0.7020219 2.1353224 0.27072500 0.27393333 0.28566667 0.01173333 0.93681214 0.02609754 FALSE TRUE
ENST00000537258 ENSG00000110756 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS5 protein_coding protein_coding 7.231863 2.886106 11.65518 0.2892096 0.1337553 2.010022 0.5631987 0.52910100 0.8830190 0.07988725 0.1894512 0.7281352 0.09664167 0.19243333 0.07596667 -0.11646667 0.10903225 0.02609754 FALSE TRUE
ENST00000544218 ENSG00000110756 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS5 protein_coding protein_coding 7.231863 2.886106 11.65518 0.2892096 0.1337553 2.010022 0.5994541 0.13721128 1.3959533 0.13721128 0.3541058 3.2555885 0.07486667 0.04023333 0.12050000 0.08026667 0.30064657 0.02609754 TRUE FALSE
MSTRG.5243.4 ENSG00000110756 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS5 protein_coding   7.231863 2.886106 11.65518 0.2892096 0.1337553 2.010022 0.8820439 0.05299909 1.5632865 0.05299909 0.2766266 4.6423066 0.08327500 0.01553333 0.13450000 0.11896667 0.02609754 0.02609754 FALSE TRUE
MSTRG.5243.6 ENSG00000110756 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS5 protein_coding   7.231863 2.886106 11.65518 0.2892096 0.1337553 2.010022 0.3275372 0.00000000 0.9358991 0.00000000 0.5183493 6.5636144 0.03135000 0.00000000 0.07933333 0.07933333 0.38669682 0.02609754 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110756 E001 0.4427912 0.1895790111 7.057775e-01 8.040868e-01 11 18278668 18278675 8 - 0.133 0.200 0.703
ENSG00000110756 E002 20.1934304 0.0709570330 1.062469e-03 4.175185e-03 11 18278676 18279058 383 - 1.085 1.583 1.742
ENSG00000110756 E003 44.1950868 0.0005345601 4.385000e-10 6.938320e-09 11 18279059 18279333 275 - 1.491 1.830 1.153
ENSG00000110756 E004 72.3719330 0.0073096770 4.411994e-07 3.945056e-06 11 18279334 18279617 284 - 1.720 2.014 0.993
ENSG00000110756 E005 38.0722540 0.0032451322 3.406933e-03 1.145807e-02 11 18279618 18279667 50 - 1.486 1.677 0.652
ENSG00000110756 E006 74.8048989 0.0004306846 2.626402e-05 1.584071e-04 11 18279668 18279942 275 - 1.776 1.960 0.621
ENSG00000110756 E007 2.2948243 0.0061597796 7.803711e-01 8.588548e-01 11 18280509 18280642 134 - 0.473 0.526 0.257
ENSG00000110756 E008 0.0000000       11 18281914 18281949 36 -      
ENSG00000110756 E009 75.6372933 0.0004048544 3.398572e-03 1.143401e-02 11 18281950 18282220 271 - 1.797 1.928 0.441
ENSG00000110756 E010 0.7771569 0.0154125579 8.862647e-01 9.312667e-01 11 18283793 18283794 2 - 0.235 0.201 -0.282
ENSG00000110756 E011 49.7270801 0.0004738288 2.625595e-01 4.003535e-01 11 18283795 18283901 107 - 1.639 1.704 0.221
ENSG00000110756 E012 29.3992008 0.0007020324 1.905442e-02 4.945341e-02 11 18285346 18285372 27 - 1.383 1.547 0.564
ENSG00000110756 E013 49.4740238 0.0004464857 5.887985e-04 2.492650e-03 11 18285373 18285459 87 - 1.597 1.782 0.627
ENSG00000110756 E014 57.8200519 0.0004385925 2.349707e-01 3.683128e-01 11 18286591 18286710 120 - 1.705 1.769 0.218
ENSG00000110756 E015 5.6290354 0.0638321920 5.059102e-01 6.416151e-01 11 18286711 18286914 204 - 0.740 0.843 0.410
ENSG00000110756 E016 61.8282323 0.0004105419 2.337961e-01 3.668953e-01 11 18287535 18287690 156 - 1.765 1.709 -0.191
ENSG00000110756 E017 0.7363589 0.0155250161 2.226883e-01 3.535908e-01 11 18287891 18287892 2 - 0.278 0.000 -11.295
ENSG00000110756 E018 48.1936700 0.0009814902 3.463897e-01 4.905268e-01 11 18287893 18288013 121 - 1.658 1.608 -0.172
ENSG00000110756 E019 92.3161017 0.0014479093 1.245451e-02 3.462883e-02 11 18291442 18292019 578 - 1.948 1.837 -0.373
ENSG00000110756 E020 40.4573856 0.0005690748 2.817966e-02 6.836760e-02 11 18292899 18292976 78 - 1.605 1.467 -0.473
ENSG00000110756 E021 49.6692942 0.0005294579 1.684381e-01 2.861455e-01 11 18295020 18295169 150 - 1.676 1.601 -0.255
ENSG00000110756 E022 46.1336642 0.0014800144 6.895243e-01 7.913942e-01 11 18295999 18296122 124 - 1.617 1.644 0.092
ENSG00000110756 E023 1.9250739 0.0080957510 1.691584e-02 4.474837e-02 11 18296162 18296797 636 - 0.523 0.000 -12.674
ENSG00000110756 E024 51.4399076 0.0011699421 1.424406e-01 2.513594e-01 11 18296798 18296984 187 - 1.689 1.608 -0.278
ENSG00000110756 E025 36.9691644 0.0005867187 4.862531e-03 1.554833e-02 11 18297559 18297717 159 - 1.573 1.380 -0.662
ENSG00000110756 E026 41.8774247 0.0102342873 7.573850e-03 2.270388e-02 11 18298792 18298970 179 - 1.630 1.403 -0.777
ENSG00000110756 E027 29.2609716 0.0426758480 1.174162e-01 2.162628e-01 11 18300828 18300916 89 - 1.476 1.264 -0.735
ENSG00000110756 E028 28.0188802 0.0453095356 3.110840e-01 4.535304e-01 11 18305422 18305493 72 - 1.443 1.306 -0.475
ENSG00000110756 E029 48.4733009 0.0072205747 2.757597e-03 9.545377e-03 11 18306135 18306347 213 - 1.694 1.468 -0.772
ENSG00000110756 E030 33.8341624 0.0005729884 1.286840e-03 4.933108e-03 11 18308946 18309079 134 - 1.545 1.311 -0.808
ENSG00000110756 E031 40.8745846 0.0005329253 1.551656e-05 9.868952e-05 11 18310741 18310933 193 - 1.633 1.336 -1.024
ENSG00000110756 E032 23.3696427 0.0111238851 2.213970e-04 1.055462e-03 11 18311387 18311451 65 - 1.414 1.018 -1.405
ENSG00000110756 E033 0.1515154 0.0429807758 1.000000e+00   11 18311517 18311913 397 - 0.072 0.000 -8.974
ENSG00000110756 E034 19.2635917 0.0093240327 9.578251e-03 2.772835e-02 11 18311914 18311955 42 - 1.317 1.042 -0.980
ENSG00000110756 E035 24.8178526 0.0017179114 1.754155e-02 4.613114e-02 11 18311956 18312024 69 - 1.411 1.213 -0.692
ENSG00000110756 E036 1.1050531 0.0119709611 5.585141e-01 6.867492e-01 11 18314404 18314519 116 - 0.317 0.202 -0.866
ENSG00000110756 E037 12.9768409 0.0044988363 2.089258e-01 3.372388e-01 11 18317751 18317907 157 - 1.132 0.993 -0.505
ENSG00000110756 E038 14.4454566 0.0062513448 7.943127e-02 1.586323e-01 11 18321946 18322076 131 - 1.186 0.993 -0.699
ENSG00000110756 E039 12.1599832 0.0353679884 6.686275e-02 1.381557e-01 11 18322077 18322132 56 - 1.132 0.871 -0.966
ENSG00000110756 E040 13.7893636 0.0027745749 2.363998e-03 8.349845e-03 11 18322133 18322254 122 - 1.196 0.839 -1.318