ENSG00000110721

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265689 ENSG00000110721 HEK293_OSMI2_2hA HEK293_TMG_2hB CHKA protein_coding protein_coding 26.47567 27.89813 25.83977 1.263569 0.7548102 -0.1105338 22.6686 24.562 20.9599 1.129869 0.7007095 -0.2286952 0.8549667 0.8805333 0.8109333 -0.0696 0.006770262 0.006770262 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110721 E001 503.824393 0.0038702197 1.023195e-07 1.037048e-06 11 68052859 68053511 653 - 2.574 2.757 0.609
ENSG00000110721 E002 106.490371 0.0028973323 1.080155e-07 1.090498e-06 11 68053512 68053514 3 - 1.858 2.107 0.838
ENSG00000110721 E003 417.165320 0.0010914457 2.839879e-04 1.314744e-03 11 68053515 68053819 305 - 2.554 2.648 0.312
ENSG00000110721 E004 276.048333 0.0002346914 6.237356e-01 7.402451e-01 11 68053820 68053930 111 - 2.421 2.443 0.075
ENSG00000110721 E005 275.023237 0.0006106808 7.643876e-01 8.474787e-01 11 68053931 68054047 117 - 2.423 2.442 0.064
ENSG00000110721 E006 3.250372 0.0046796733 7.804855e-01 8.589358e-01 11 68061493 68061599 107 - 0.596 0.648 0.226
ENSG00000110721 E007 9.512895 0.0017463469 8.006842e-01 8.729678e-01 11 68061600 68061830 231 - 1.024 1.008 -0.058
ENSG00000110721 E008 208.555339 0.0001899449 1.405461e-01 2.487896e-01 11 68061953 68062034 82 - 2.285 2.333 0.162
ENSG00000110721 E009 260.943436 0.0002293311 3.618462e-01 5.062499e-01 11 68064525 68064631 107 - 2.390 2.422 0.107
ENSG00000110721 E010 248.686611 0.0006847841 8.206613e-02 1.627844e-01 11 68065786 68065894 109 - 2.354 2.408 0.181
ENSG00000110721 E011 185.463139 0.0002111598 5.900899e-02 1.249389e-01 11 68066429 68066471 43 - 2.284 2.246 -0.127
ENSG00000110721 E012 187.528387 0.0002421792 1.675335e-01 2.849802e-01 11 68066472 68066502 31 - 2.280 2.255 -0.083
ENSG00000110721 E013 158.122464 0.0002279539 8.576896e-02 1.686229e-01 11 68066503 68066516 14 - 2.215 2.178 -0.124
ENSG00000110721 E014 172.137664 0.0015318550 1.634844e-02 4.349277e-02 11 68068879 68068937 59 - 2.269 2.201 -0.227
ENSG00000110721 E015 167.807658 0.0026135972 2.636383e-03 9.178457e-03 11 68070189 68070222 34 - 2.274 2.174 -0.337
ENSG00000110721 E016 198.058329 0.0024958780 2.027921e-02 5.207117e-02 11 68070223 68070293 71 - 2.330 2.259 -0.238
ENSG00000110721 E017 198.398167 0.0040713977 4.917599e-02 1.076898e-01 11 68070724 68070815 92 - 2.331 2.262 -0.231
ENSG00000110721 E018 148.975626 0.0026861317 3.187642e-01 4.617384e-01 11 68070816 68070857 42 - 2.184 2.155 -0.098
ENSG00000110721 E019 186.418924 0.0005700465 1.405842e-01 2.488345e-01 11 68074717 68074830 114 - 2.284 2.255 -0.097
ENSG00000110721 E020 114.369800 0.0003270216 1.298616e-02 3.587798e-02 11 68081404 68081457 54 - 2.099 2.028 -0.236
ENSG00000110721 E021 2.297968 0.1711020919 9.035477e-01 9.426318e-01 11 68081458 68081726 269 - 0.508 0.516 0.040
ENSG00000110721 E022 7.950745 0.0027574522 7.157089e-01 8.115679e-01 11 68081727 68082098 372 - 0.959 0.928 -0.117
ENSG00000110721 E023 1.845689 0.0091705921 1.819469e-01 3.036488e-01 11 68082491 68082520 30 - 0.554 0.333 -1.163
ENSG00000110721 E024 1.301633 0.0126418627 7.274044e-02 1.479098e-01 11 68089821 68089880 60 - 0.507 0.197 -1.941
ENSG00000110721 E025 126.260911 0.0008284320 1.624631e-05 1.028683e-04 11 68097019 68097130 112 - 2.171 2.038 -0.447
ENSG00000110721 E026 1.072597 0.0265809960 9.989494e-01 1.000000e+00 11 68120790 68120827 38 - 0.323 0.331 0.051
ENSG00000110721 E027 90.571847 0.0034112127 2.209707e-17 1.030075e-15 11 68120828 68121444 617 - 2.142 1.759 -1.289