ENSG00000110697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356404 ENSG00000110697 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNM1 protein_coding protein_coding 8.966589 13.55091 6.369291 1.053873 0.09690283 -1.087986 3.0027174 8.7257992 0.0000000 0.75754651 0.00000000 -9.7707959 0.24300000 0.64420000 0.00000000 -0.644200000 2.737692e-49 2.737692e-49 FALSE TRUE
ENST00000436757 ENSG00000110697 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNM1 protein_coding protein_coding 8.966589 13.55091 6.369291 1.053873 0.09690283 -1.087986 1.6993187 1.9909238 1.4609621 0.16221318 0.10677131 -0.4439061 0.19986250 0.14686667 0.22993333 0.083066667 3.753251e-02 2.737692e-49 FALSE TRUE
ENST00000525568 ENSG00000110697 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNM1 protein_coding retained_intron 8.966589 13.55091 6.369291 1.053873 0.09690283 -1.087986 0.4786258 0.2586456 0.6138926 0.13105620 0.44109945 1.2155933 0.05922500 0.02006667 0.09460000 0.074533333 7.958665e-01 2.737692e-49 FALSE FALSE
ENST00000526450 ENSG00000110697 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNM1 protein_coding retained_intron 8.966589 13.55091 6.369291 1.053873 0.09690283 -1.087986 0.7689651 1.1711902 0.5306644 0.44139021 0.17436777 -1.1274359 0.07616667 0.08283333 0.08416667 0.001333333 1.000000e+00 2.737692e-49 TRUE FALSE
ENST00000527370 ENSG00000110697 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNM1 protein_coding retained_intron 8.966589 13.55091 6.369291 1.053873 0.09690283 -1.087986 0.4726198 0.3231736 0.3789416 0.06227837 0.08892399 0.2232797 0.06478333 0.02410000 0.05906667 0.034966667 8.296924e-02 2.737692e-49 FALSE TRUE
MSTRG.5829.1 ENSG00000110697 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNM1 protein_coding   8.966589 13.55091 6.369291 1.053873 0.09690283 -1.087986 1.1516776 0.0000000 2.3827246 0.00000000 0.15556730 7.9025106 0.19237083 0.00000000 0.37496667 0.374966667 2.603548e-36 2.737692e-49 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110697 E001 0.5514428 0.0196508469 4.306327e-01 5.732339e-01 11 67491147 67491171 25 - 0.000 0.193 9.322
ENSG00000110697 E002 1.0382412 0.0134424862 6.462784e-01 7.582367e-01 11 67491449 67491767 319 - 0.329 0.242 -0.603
ENSG00000110697 E003 0.2987644 0.0273143511 3.472238e-02   11 67491768 67491768 1 - 0.329 0.000 -14.136
ENSG00000110697 E004 46.5988239 0.0004741692 1.974256e-05 1.226113e-04 11 67491769 67492009 241 - 1.342 1.634 1.002
ENSG00000110697 E005 144.0012605 0.0012398137 1.749780e-10 2.961589e-09 11 67492010 67492296 287 - 1.846 2.115 0.901
ENSG00000110697 E006 114.6305586 0.0027862592 2.546626e-04 1.194658e-03 11 67492934 67493062 129 - 1.825 2.004 0.603
ENSG00000110697 E007 67.5137760 0.0087182977 1.625645e-01 2.784924e-01 11 67493410 67493443 34 - 1.666 1.764 0.331
ENSG00000110697 E008 93.5123835 0.0032462963 6.104073e-02 1.283860e-01 11 67493444 67493552 109 - 1.802 1.901 0.332
ENSG00000110697 E009 48.2677262 0.0005101742 2.332834e-01 3.663153e-01 11 67493553 67493593 41 - 1.544 1.615 0.239
ENSG00000110697 E010 87.1603351 0.0003332412 1.488177e-02 4.022523e-02 11 67493688 67493837 150 - 1.766 1.876 0.373
ENSG00000110697 E011 7.5939608 0.0684031372 2.856514e-01 4.260114e-01 11 67493838 67493921 84 - 0.977 0.805 -0.656
ENSG00000110697 E012 83.5105912 0.0003725921 3.109467e-02 7.409149e-02 11 67493922 67494070 149 - 1.757 1.856 0.335
ENSG00000110697 E013 58.9856693 0.0004445017 8.766182e-02 1.715786e-01 11 67494244 67494295 52 - 1.616 1.708 0.314
ENSG00000110697 E014 61.7739758 0.0009979089 3.159387e-01 4.587138e-01 11 67494296 67494360 65 - 1.672 1.724 0.176
ENSG00000110697 E015 81.1617469 0.0016748911 3.596803e-01 5.039988e-01 11 67494846 67494956 111 - 1.794 1.838 0.147
ENSG00000110697 E016 67.3834655 0.0006912198 2.222197e-01 3.530568e-01 11 67495077 67495139 63 - 1.697 1.758 0.206
ENSG00000110697 E017 65.8275667 0.0004209489 2.990825e-02 7.177820e-02 11 67495140 67495225 86 - 1.645 1.758 0.383
ENSG00000110697 E018 1.9389278 0.3334470230 1.188861e-01 2.183460e-01 11 67495226 67495279 54 - 0.746 0.244 -2.603
ENSG00000110697 E019 94.3093617 0.0004187133 8.813598e-01 9.279619e-01 11 67495438 67495602 165 - 1.899 1.890 -0.032
ENSG00000110697 E020 95.3340157 0.0003370384 8.452334e-01 9.037273e-01 11 67496178 67496345 168 - 1.890 1.895 0.018
ENSG00000110697 E021 27.7998571 0.0055745417 2.828887e-01 4.229500e-01 11 67496346 67496348 3 - 1.295 1.388 0.324
ENSG00000110697 E022 8.5840637 0.0508853391 8.284251e-04 3.360944e-03 11 67496349 67497230 882 - 1.228 0.731 -1.862
ENSG00000110697 E023 84.3625845 0.0003159044 4.579549e-01 5.982911e-01 11 67497231 67497436 206 - 1.817 1.848 0.104
ENSG00000110697 E024 72.1149586 0.0005171665 2.536509e-01 3.902117e-01 11 67497522 67497679 158 - 1.735 1.789 0.183
ENSG00000110697 E025 71.6059510 0.0036172415 4.537802e-01 5.944851e-01 11 67497917 67498024 108 - 1.810 1.767 -0.145
ENSG00000110697 E026 99.6093472 0.0002929551 2.410676e-01 3.754299e-01 11 67498133 67498322 190 - 1.952 1.901 -0.170
ENSG00000110697 E027 5.5265339 0.1077031955 8.390652e-03 2.476682e-02 11 67498323 67498595 273 - 1.072 0.593 -1.888
ENSG00000110697 E028 102.8646768 0.0003108623 8.367166e-02 1.653041e-01 11 67498596 67498846 251 - 1.981 1.909 -0.241
ENSG00000110697 E029 54.3027099 0.0004925570 7.076192e-02 1.446084e-01 11 67498940 67499001 62 - 1.730 1.630 -0.340
ENSG00000110697 E030 0.4427912 0.1969925885 1.706111e-01 2.889543e-01 11 67499639 67499722 84 - 0.329 0.074 -2.618
ENSG00000110697 E031 48.8097019 0.0077464804 5.549881e-02 1.188388e-01 11 67499723 67499770 48 - 1.716 1.581 -0.458
ENSG00000110697 E032 55.1783569 0.0134805680 1.890058e-01 3.124997e-01 11 67499771 67499830 60 - 1.744 1.643 -0.341
ENSG00000110697 E033 1.4842667 0.0905844698 5.834805e-01 7.075921e-01 11 67499831 67499913 83 - 0.432 0.325 -0.614
ENSG00000110697 E034 57.7781800 0.0058472217 4.168991e-02 9.416989e-02 11 67499914 67500009 96 - 1.782 1.653 -0.438
ENSG00000110697 E035 0.2987644 0.0273143511 3.472238e-02   11 67500010 67500013 4 - 0.329 0.000 -14.136
ENSG00000110697 E036 101.2901149 0.0002787529 5.033840e-03 1.602363e-02 11 67500095 67500421 327 - 2.006 1.893 -0.380
ENSG00000110697 E037 66.1693167 0.0004097879 2.757566e-01 4.151271e-01 11 67501862 67501967 106 - 1.778 1.721 -0.194
ENSG00000110697 E038 39.2943119 0.0044754241 1.669962e-01 2.842798e-01 11 67501968 67502012 45 - 1.585 1.488 -0.332
ENSG00000110697 E039 42.2581511 0.0012373903 1.805848e-01 3.019182e-01 11 67502013 67502038 26 - 1.610 1.523 -0.295
ENSG00000110697 E040 36.6434821 0.0076259827 4.542854e-01 5.949453e-01 11 67502039 67502046 8 - 1.530 1.472 -0.201
ENSG00000110697 E041 48.4204209 0.0006071034 2.366574e-01 3.703088e-01 11 67502047 67502086 40 - 1.656 1.584 -0.243
ENSG00000110697 E042 2.6289719 0.0080237905 1.063502e-01 2.001522e-01 11 67502087 67502291 205 - 0.696 0.428 -1.241
ENSG00000110697 E043 39.4986731 0.0006699279 5.587035e-02 1.194662e-01 11 67502292 67502296 5 - 1.610 1.487 -0.418
ENSG00000110697 E044 68.2853470 0.0004036977 2.634471e-02 6.463759e-02 11 67502297 67502413 117 - 1.832 1.722 -0.371
ENSG00000110697 E045 38.2569420 0.0013827374 9.049055e-02 1.759031e-01 11 67502504 67502532 29 - 1.591 1.479 -0.383
ENSG00000110697 E046 60.4096401 0.0005485555 4.785151e-04 2.077821e-03 11 67502533 67502718 186 - 1.828 1.651 -0.601
ENSG00000110697 E047 0.7771569 0.0144517344 1.053552e-02 3.005623e-02 11 67503840 67503876 37 - 0.514 0.074 -3.603
ENSG00000110697 E048 28.4870831 0.0020132764 4.051013e-02 9.195526e-02 11 67504103 67504221 119 - 1.492 1.338 -0.533
ENSG00000110697 E049 0.5159433 0.2156207966 1.786525e-01 2.994618e-01 11 67504222 67504369 148 - 0.329 0.075 -2.581
ENSG00000110697 E050 0.1451727 0.0429583236 1.542926e-01   11 67504522 67504557 36 - 0.195 0.000 -13.092
ENSG00000110697 E051 2.0792529 0.3522470971 1.528070e-01 2.654702e-01 11 67504794 67505187 394 - 0.694 0.326 -1.819
ENSG00000110697 E052 14.8432528 0.0174162129 8.611141e-02 1.691722e-01 11 67505188 67505365 178 - 1.255 1.063 -0.687
ENSG00000110697 E053 0.0000000       11 67506176 67506263 88 -