ENSG00000110693

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316399 ENSG00000110693 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX6 protein_coding protein_coding 0.595612 0.3885363 1.123935 0.03687665 0.1489758 1.508555 0.11836320 0.26052222 0.00000000 0.01484284 0.00000000 -4.7576752 0.30360833 0.68103333 0.00000000 -0.68103333 2.889986e-10 2.889986e-10 FALSE TRUE
ENST00000396356 ENSG00000110693 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX6 protein_coding protein_coding 0.595612 0.3885363 1.123935 0.03687665 0.1489758 1.508555 0.09422024 0.00000000 0.39649264 0.00000000 0.01757876 5.3451573 0.08359167 0.00000000 0.36700000 0.36700000 4.666755e-04 2.889986e-10 FALSE TRUE
ENST00000525259 ENSG00000110693 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX6 protein_coding processed_transcript 0.595612 0.3885363 1.123935 0.03687665 0.1489758 1.508555 0.08043844 0.03101323 0.06590009 0.03101323 0.06590009 0.8880121 0.14523750 0.06856667 0.06636667 -0.00220000 8.878123e-01 2.889986e-10   FALSE
ENST00000525835 ENSG00000110693 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX6 protein_coding processed_transcript 0.595612 0.3885363 1.123935 0.03687665 0.1489758 1.508555 0.09723962 0.04379325 0.19289575 0.02270880 0.07123544 1.9152416 0.10671250 0.11280000 0.16306667 0.05026667 7.896687e-01 2.889986e-10   FALSE
ENST00000528429 ENSG00000110693 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX6 protein_coding protein_coding 0.595612 0.3885363 1.123935 0.03687665 0.1489758 1.508555 0.01511237 0.00000000 0.08311550 0.00000000 0.08311550 3.2190213 0.01088333 0.00000000 0.05850000 0.05850000 1.000000e+00 2.889986e-10 FALSE TRUE
ENST00000655819 ENSG00000110693 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX6 protein_coding protein_coding 0.595612 0.3885363 1.123935 0.03687665 0.1489758 1.508555 0.12254217 0.00000000 0.21226444 0.00000000 0.03079363 4.4742052 0.25465417 0.00000000 0.19546667 0.19546667 1.841516e-02 2.889986e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110693 E001 50.1786747 0.0007389292 5.865473e-19 3.320969e-17 11 15966449 15969532 3084 - 1.555 1.866 1.054
ENSG00000110693 E002 29.0453151 0.0115849265 2.113802e-01 3.401139e-01 11 15969533 15972698 3166 - 1.498 1.361 -0.471
ENSG00000110693 E003 1.6189451 0.0091320969 4.063154e-01 5.499802e-01 11 15972699 15972707 9 - 0.356 0.477 0.656
ENSG00000110693 E004 8.4336902 0.0025869196 3.492762e-01 4.934953e-01 11 15972708 15973112 405 - 0.995 0.845 -0.567
ENSG00000110693 E005 2.6677980 0.0063326192 8.790860e-01 9.263453e-01 11 15986204 15986264 61 - 0.549 0.544 -0.023
ENSG00000110693 E006 3.4104996 0.0053877684 5.931111e-01 7.155588e-01 11 15986265 15986420 156 - 0.663 0.544 -0.525
ENSG00000110693 E007 2.6122262 0.0059050240 1.114939e-01 2.077463e-01 11 15988997 15989170 174 - 0.621 0.301 -1.665
ENSG00000110693 E008 1.3212023 0.0117288281 3.085234e-02 7.362889e-02 11 15989171 15989230 60 - 0.463 0.000 -13.568
ENSG00000110693 E009 2.3155380 0.0074533622 1.841103e-01 3.063821e-01 11 16014942 16015050 109 - 0.574 0.301 -1.459
ENSG00000110693 E010 0.0000000       11 16015253 16015327 75 -      
ENSG00000110693 E011 3.0697792 0.0138612982 1.878334e-01 3.110047e-01 11 16046514 16046701 188 - 0.663 0.398 -1.262
ENSG00000110693 E012 0.4396707 0.0247002471 3.633702e-01 5.077850e-01 11 16049713 16049754 42 - 0.214 0.000 -12.263
ENSG00000110693 E013 1.5229790 0.0106166221 5.745813e-01 7.003642e-01 11 16049755 16049781 27 - 0.430 0.301 -0.761
ENSG00000110693 E014 2.1119751 0.0684429059 2.859023e-01 4.262682e-01 11 16049782 16049938 157 - 0.549 0.300 -1.350
ENSG00000110693 E015 2.5257233 0.0425115674 3.006035e-02 7.207294e-02 11 16055752 16055901 150 - 0.642 0.176 -2.764
ENSG00000110693 E016 1.1844487 0.0143479602 4.533411e-02 1.008046e-01 11 16095996 16096118 123 - 0.430 0.000 -13.434
ENSG00000110693 E017 1.0445865 0.0698909634 4.244503e-01 5.674243e-01 11 16097609 16097688 80 - 0.356 0.176 -1.352
ENSG00000110693 E018 0.0000000       11 16110320 16110399 80 -      
ENSG00000110693 E019 0.4470576 0.0230771553 8.254406e-01 8.900545e-01 11 16111803 16111923 121 - 0.153 0.176 0.238
ENSG00000110693 E020 1.0308569 0.0137125610 6.608096e-02 1.368478e-01 11 16183886 16183954 69 - 0.395 0.000 -13.286
ENSG00000110693 E021 0.0000000       11 16186781 16186782 2 -      
ENSG00000110693 E022 2.2896155 0.0064638203 3.886920e-02 8.894161e-02 11 16186783 16186955 173 - 0.598 0.176 -2.566
ENSG00000110693 E023 2.7356290 0.0056984620 1.570847e-02 4.208093e-02 11 16234582 16234639 58 - 0.663 0.176 -2.846
ENSG00000110693 E024 1.7756348 0.0396528258 1.318484e-02 3.634021e-02 11 16234640 16234671 32 - 0.549 0.000 -13.826
ENSG00000110693 E025 0.0000000       11 16252373 16252536 164 -      
ENSG00000110693 E026 0.1472490 0.0422879425 1.000000e+00   11 16264449 16264846 398 - 0.083 0.000 -10.799
ENSG00000110693 E027 0.0000000       11 16269944 16270068 125 -      
ENSG00000110693 E028 0.0000000       11 16283756 16283918 163 -      
ENSG00000110693 E029 0.0000000       11 16311245 16318002 6758 -      
ENSG00000110693 E030 0.1472490 0.0422879425 1.000000e+00   11 16318026 16318445 420 - 0.083 0.000 -10.799
ENSG00000110693 E031 2.7440480 0.0096944340 1.651654e-02 4.388019e-02 11 16318446 16318471 26 - 0.663 0.176 -2.846
ENSG00000110693 E032 4.0854364 0.0054742641 7.856714e-03 2.342105e-02 11 16318472 16318653 182 - 0.799 0.301 -2.404
ENSG00000110693 E033 0.0000000       11 16341011 16341011 1 -      
ENSG00000110693 E034 3.9202164 0.0042893072 4.435630e-02 9.903441e-02 11 16341012 16341252 241 - 0.769 0.398 -1.698
ENSG00000110693 E035 0.0000000       11 16341253 16341269 17 -      
ENSG00000110693 E036 0.0000000       11 16356094 16356546 453 -      
ENSG00000110693 E037 0.0000000       11 16382288 16382398 111 -      
ENSG00000110693 E038 0.0000000       11 16397458 16397562 105 -      
ENSG00000110693 E039 0.0000000       11 16402659 16402799 141 -      
ENSG00000110693 E040 0.0000000       11 16402800 16402867 68 -      
ENSG00000110693 E041 0.0000000       11 16408698 16408884 187 -      
ENSG00000110693 E042 0.0000000       11 16434144 16434450 307 -      
ENSG00000110693 E043 0.1515154 0.0440650590 1.000000e+00   11 16465701 16465780 80 - 0.083 0.000 -10.796
ENSG00000110693 E044 0.1515154 0.0440650590 1.000000e+00   11 16465781 16465790 10 - 0.083 0.000 -10.796
ENSG00000110693 E045 0.0000000       11 16465791 16465816 26 -      
ENSG00000110693 E046 1.1845624 0.0110049824 4.447523e-02 9.924729e-02 11 16476315 16476337 23 - 0.430 0.000 -13.440
ENSG00000110693 E047 1.3620004 0.0098319313 2.274020e-01 3.592957e-01 11 16476338 16476388 51 - 0.430 0.176 -1.759
ENSG00000110693 E048 0.1451727 0.0447453765 1.000000e+00   11 16567327 16567378 52 - 0.083 0.000 -10.794
ENSG00000110693 E049 0.3268771 0.0290076054 4.828359e-01   11 16605901 16605991 91 - 0.083 0.176 1.241
ENSG00000110693 E050 1.7360052 0.0081597943 9.734854e-01 9.874332e-01 11 16607178 16607727 550 - 0.430 0.398 -0.174
ENSG00000110693 E051 0.3289534 0.0289248153 4.824662e-01   11 16612081 16612260 180 - 0.083 0.176 1.241
ENSG00000110693 E052 1.3296188 0.0118685185 5.501320e-01 6.797958e-01 11 16714830 16714905 76 - 0.314 0.398 0.505
ENSG00000110693 E053 1.7714796 0.0081333665 9.752238e-01 9.885666e-01 11 16736339 16736472 134 - 0.430 0.398 -0.173
ENSG00000110693 E054 1.1082728 0.0172576443 2.521528e-01 3.884780e-01 11 16738425 16738643 219 - 0.214 0.399 1.246
ENSG00000110693 E055 0.0000000       11 16739459 16739591 133 -