ENSG00000110651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263645 ENSG00000110651 HEK293_OSMI2_2hA HEK293_TMG_2hB CD81 protein_coding protein_coding 609.8273 961.4658 381.7104 36.59886 2.61517 -1.332734 162.0207 198.8920 146.9315 14.49162 3.462969 -0.4368153 0.2819083 0.2063 0.3848667 0.1785667 1.008326e-20 1.008326e-20 FALSE TRUE
ENST00000527343 ENSG00000110651 HEK293_OSMI2_2hA HEK293_TMG_2hB CD81 protein_coding protein_coding 609.8273 961.4658 381.7104 36.59886 2.61517 -1.332734 435.0068 746.1085 226.9989 21.30735 2.138984 -1.7166557 0.6959917 0.7766 0.5947667 -0.1818333 2.187956e-18 1.008326e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110651 E001 0.000000e+00       11 2376177 2376201 25 +      
ENSG00000110651 E002 0.000000e+00       11 2376202 2376357 156 +      
ENSG00000110651 E003 0.000000e+00       11 2376821 2376920 100 +      
ENSG00000110651 E004 0.000000e+00       11 2377310 2377315 6 +      
ENSG00000110651 E005 6.537541e-01 4.969477e-01 4.869469e-01 6.246609e-01 11 2377316 2377317 2 + 0.305 0.151 -1.290
ENSG00000110651 E006 2.562842e+00 1.704648e-01 1.413098e-01 2.498341e-01 11 2377318 2377334 17 + 0.707 0.422 -1.315
ENSG00000110651 E007 1.300205e+03 1.883227e-04 4.845728e-75 8.500080e-72 11 2377335 2377615 281 + 3.187 2.991 -0.653
ENSG00000110651 E008 1.023493e+00 1.790992e-02 7.605249e-01 8.446117e-01 11 2379156 2379206 51 + 0.306 0.262 -0.308
ENSG00000110651 E009 1.333898e+00 6.855914e-02 5.955639e-02 1.258579e-01 11 2382460 2382550 91 + 0.552 0.211 -2.038
ENSG00000110651 E010 4.481018e-01 1.388126e-01 8.028336e-01 8.744425e-01 11 2384650 2384662 13 + 0.180 0.148 -0.332
ENSG00000110651 E011 7.780993e-01 5.384591e-02 7.224473e-01 8.165467e-01 11 2384663 2384682 20 + 0.180 0.260 0.679
ENSG00000110651 E012 1.654443e+00 4.194856e-01 8.186358e-01 8.853880e-01 11 2385666 2385806 141 + 0.307 0.400 0.552
ENSG00000110651 E013 1.217882e+00 6.133748e-02 9.585551e-01 9.780282e-01 11 2386057 2386085 29 + 0.307 0.309 0.016
ENSG00000110651 E014 1.291034e+00 2.585945e-01 9.842342e-01 9.942424e-01 11 2386086 2386156 71 + 0.307 0.316 0.056
ENSG00000110651 E015 4.158968e+00 4.054303e-03 5.411062e-01 6.721324e-01 11 2386157 2386554 398 + 0.707 0.635 -0.308
ENSG00000110651 E016 4.852372e+00 4.671605e-03 1.194528e-01 2.191660e-01 11 2386555 2386639 85 + 0.484 0.761 1.217
ENSG00000110651 E017 1.579187e+00 3.341125e-02 4.893526e-02 1.072631e-01 11 2390095 2390102 8 + 0.001 0.426 10.266
ENSG00000110651 E018 3.007906e+00 4.225243e-02 1.712060e-01 2.897578e-01 11 2390103 2390183 81 + 0.306 0.595 1.519
ENSG00000110651 E019 1.958180e+03 7.492347e-05 1.489020e-57 1.389608e-54 11 2390412 2390445 34 + 3.316 3.192 -0.412
ENSG00000110651 E020 3.428016e+03 1.779169e-04 2.053767e-23 1.903523e-21 11 2390446 2390526 81 + 3.516 3.454 -0.205
ENSG00000110651 E021 1.410883e+01 1.930930e-02 4.321304e-02 9.694227e-02 11 2391075 2391382 308 + 1.266 1.062 -0.729
ENSG00000110651 E022 1.210672e+01 5.552477e-02 3.632426e-01 5.076740e-01 11 2391383 2391482 100 + 1.141 1.020 -0.439
ENSG00000110651 E023 1.463009e+02 8.407646e-03 4.460795e-03 1.443158e-02 11 2391483 2393847 2365 + 2.194 2.067 -0.424
ENSG00000110651 E024 4.419265e+01 6.264723e-04 1.194979e-01 2.192296e-01 11 2393848 2394094 247 + 1.639 1.573 -0.224
ENSG00000110651 E025 4.599084e+03 1.348812e-04 4.137504e-06 2.998270e-05 11 2394095 2394192 98 + 3.604 3.596 -0.026
ENSG00000110651 E026 3.603587e+01 8.448081e-04 4.932687e-01 6.302958e-01 11 2394850 2394971 122 + 1.522 1.503 -0.067
ENSG00000110651 E027 4.747495e+03 4.609957e-04 3.113209e-03 1.059893e-02 11 2394972 2395046 75 + 3.566 3.629 0.207
ENSG00000110651 E028 2.414085e+01 8.180042e-04 3.725520e-01 5.169930e-01 11 2395047 2395415 369 + 1.372 1.328 -0.153
ENSG00000110651 E029 3.783474e+03 1.025509e-03 3.269392e-01 4.703848e-01 11 2395416 2395448 33 + 3.479 3.526 0.154
ENSG00000110651 E030 3.321152e+03 8.536915e-04 9.356694e-01 9.635201e-01 11 2395449 2395457 9 + 3.436 3.465 0.097
ENSG00000110651 E031 5.176414e+03 8.952296e-05 6.272264e-01 7.430490e-01 11 2395458 2395520 63 + 3.626 3.657 0.102
ENSG00000110651 E032 2.250949e+01 8.480024e-04 4.552925e-02 1.011704e-01 11 2395521 2395868 348 + 1.408 1.278 -0.451
ENSG00000110651 E033 5.849230e+03 1.750748e-04 7.759150e-01 8.556954e-01 11 2395869 2395970 102 + 3.684 3.710 0.086
ENSG00000110651 E034 1.943107e+01 1.084404e-03 1.638819e-01 2.802069e-01 11 2395971 2396312 342 + 1.311 1.218 -0.327
ENSG00000110651 E035 3.087149e+01 2.943594e-02 5.037627e-01 6.397109e-01 11 2396313 2396627 315 + 1.472 1.431 -0.144
ENSG00000110651 E036 3.180207e+03 3.661536e-05 3.518460e-01 4.960497e-01 11 2396628 2396630 3 + 3.423 3.442 0.065
ENSG00000110651 E037 5.291628e+03 1.290257e-04 9.816189e-01 9.925532e-01 11 2396631 2396714 84 + 3.639 3.667 0.092
ENSG00000110651 E038 2.025543e+01 8.957253e-04 1.931874e-01 3.177805e-01 11 2396715 2396803 89 + 1.156 1.297 0.499
ENSG00000110651 E039 1.197853e+04 9.105145e-04 5.334445e-12 1.160269e-10 11 2396804 2397397 594 + 3.926 4.042 0.385