ENSG00000110583

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338447 ENSG00000110583 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA40 protein_coding retained_intron 26.98041 30.09599 24.46283 0.8301661 0.9013133 -0.2988693 2.4338873 1.4665569 2.289491 0.3155943 0.1603790 0.6390778 0.09062917 0.048700000 0.09360000 0.04490000 6.387547e-02 4.591993e-11 FALSE TRUE
ENST00000377793 ENSG00000110583 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA40 protein_coding protein_coding 26.98041 30.09599 24.46283 0.8301661 0.9013133 -0.2988693 16.4973463 24.5061085 11.963927 0.2953286 0.2074136 -1.0338337 0.60390833 0.815233333 0.49093333 -0.32430000 4.591993e-11 4.591993e-11 FALSE TRUE
ENST00000534965 ENSG00000110583 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA40 protein_coding nonsense_mediated_decay 26.98041 30.09599 24.46283 0.8301661 0.9013133 -0.2988693 2.5264873 1.3145430 4.513607 0.7177062 0.1674153 1.7719789 0.09808333 0.042766667 0.18536667 0.14260000 2.822621e-01 4.591993e-11 FALSE TRUE
ENST00000536939 ENSG00000110583 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA40 protein_coding processed_transcript 26.98041 30.09599 24.46283 0.8301661 0.9013133 -0.2988693 2.3297772 1.1006955 2.449831 0.2932198 0.8608505 1.1470959 0.08842500 0.036166667 0.09786667 0.06170000 1.413939e-01 4.591993e-11 FALSE TRUE
MSTRG.5650.7 ENSG00000110583 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA40 protein_coding   26.98041 30.09599 24.46283 0.8301661 0.9013133 -0.2988693 0.7813318 0.1342394 1.880870 0.1342394 0.2649378 3.7125135 0.03052917 0.004233333 0.07696667 0.07273333 1.174538e-02 4.591993e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110583 E001 0.5503986 0.0212609963 9.219615e-01 9.547701e-01 11 63938959 63938966 8 + 0.153 0.177 0.252
ENSG00000110583 E002 2.9140173 0.0051869451 9.156255e-01 9.506097e-01 11 63938967 63938983 17 + 0.548 0.575 0.124
ENSG00000110583 E003 4.9767978 0.0032312217 4.505726e-01 5.916597e-01 11 63938984 63938993 10 + 0.812 0.721 -0.364
ENSG00000110583 E004 5.1250910 0.0031579262 5.407486e-01 6.718549e-01 11 63938994 63938995 2 + 0.812 0.742 -0.282
ENSG00000110583 E005 12.6419264 0.0013633143 6.001466e-01 7.214348e-01 11 63938996 63939001 6 + 1.136 1.098 -0.134
ENSG00000110583 E006 103.2473518 0.0150185679 4.599913e-02 1.020361e-01 11 63939002 63939102 101 + 2.065 1.945 -0.403
ENSG00000110583 E007 3.0290010 0.0049968788 4.974994e-01 6.340540e-01 11 63939248 63939534 287 + 0.641 0.545 -0.428
ENSG00000110583 E008 148.3754326 0.0057760080 2.368772e-02 5.916767e-02 11 63945840 63945935 96 + 2.205 2.113 -0.306
ENSG00000110583 E009 46.9520231 0.0278518494 9.173566e-05 4.831405e-04 11 63945936 63946724 789 + 1.854 1.498 -1.208
ENSG00000110583 E010 22.7714611 0.0008983939 4.156200e-06 3.010551e-05 11 63946725 63946950 226 + 1.531 1.212 -1.105
ENSG00000110583 E011 109.2034861 0.0006257383 6.434057e-04 2.692242e-03 11 63946951 63947003 53 + 2.084 1.976 -0.362
ENSG00000110583 E012 0.7458221 0.0235130909 5.048841e-02 1.100335e-01 11 63952148 63952237 90 + 0.430 0.097 -2.753
ENSG00000110583 E013 170.5319468 0.0022448470 8.753714e-04 3.528061e-03 11 63952238 63952333 96 + 2.274 2.171 -0.344
ENSG00000110583 E014 0.4482035 0.0322969566 2.888180e-02 6.976464e-02 11 63952369 63952402 34 + 0.355 0.000 -11.639
ENSG00000110583 E015 0.7437457 0.0146530035 4.903971e-02 1.074510e-01 11 63952403 63952406 4 + 0.430 0.097 -2.752
ENSG00000110583 E016 245.2263848 0.0020759724 5.635400e-03 1.764504e-02 11 63952407 63952565 159 + 2.412 2.342 -0.234
ENSG00000110583 E017 4.5058819 0.0075097788 1.177223e-01 2.166875e-01 11 63952566 63952658 93 + 0.840 0.630 -0.856
ENSG00000110583 E018 3.6075003 0.0459608335 3.895560e-01 5.336319e-01 11 63952659 63952755 97 + 0.718 0.579 -0.596
ENSG00000110583 E019 164.4998650 0.0002465571 2.111219e-01 3.398397e-01 11 63952756 63952839 84 + 2.209 2.187 -0.072
ENSG00000110583 E020 165.4526809 0.0003316353 5.407657e-01 6.718572e-01 11 63953972 63954049 78 + 2.200 2.196 -0.012
ENSG00000110583 E021 654.3498159 0.0003031151 5.017018e-04 2.166140e-03 11 63954338 63955161 824 + 2.815 2.779 -0.121
ENSG00000110583 E022 826.6934483 0.0007967104 2.523123e-07 2.371846e-06 11 63955162 63956364 1203 + 2.826 2.921 0.316
ENSG00000110583 E023 592.0824500 0.0024973306 1.289449e-12 3.106337e-11 11 63956365 63957319 955 + 2.605 2.802 0.654
ENSG00000110583 E024 2.8356539 0.0077893653 6.587369e-01 7.677658e-01 11 63971929 63972029 101 + 0.493 0.576 0.389