ENSG00000110514

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402192 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding protein_coding 20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 1.4170304 1.3414741 1.29208250 0.19348506 0.03232843 -0.05371299 0.07050833 0.05230000 0.092866667 0.04056667 8.832540e-02 1.674548e-07 FALSE TRUE
ENST00000406482 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding protein_coding 20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 1.2550105 1.5518821 1.37900553 0.52205173 0.08198964 -0.16923323 0.06539167 0.06160000 0.099233333 0.03763333 4.562272e-01 1.674548e-07 FALSE TRUE
ENST00000460452 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding retained_intron 20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 3.1348115 2.9419895 2.06516586 0.46613319 0.50592777 -0.50846096 0.15154167 0.11210000 0.147166667 0.03506667 7.529590e-01 1.674548e-07 FALSE TRUE
ENST00000469699 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding retained_intron 20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 4.0284228 4.5237987 2.57399834 0.71126535 0.33266947 -0.81111518 0.18460833 0.17156667 0.183700000 0.01213333 9.041697e-01 1.674548e-07 FALSE TRUE
ENST00000634938 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding protein_coding 20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 1.9180677 5.7415008 0.04740124 1.34363671 0.04740124 -6.64671275 0.07268333 0.21593333 0.003066667 -0.21286667 1.674548e-07 1.674548e-07 FALSE TRUE
MSTRG.5477.12 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding   20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 1.0537142 0.7137595 1.47009346 0.12293203 0.08113066 1.03210602 0.05914583 0.02813333 0.106466667 0.07833333 3.533020e-05 1.674548e-07 FALSE TRUE
MSTRG.5477.14 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding   20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 1.6078564 0.9903242 2.59075213 0.99032415 0.27020759 1.37846133 0.09569167 0.04286667 0.184766667 0.14190000 9.753521e-02 1.674548e-07 FALSE TRUE
MSTRG.5477.16 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding   20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 0.6333022 1.9318319 0.00000000 0.97066377 0.00000000 -7.60127452 0.02554583 0.07010000 0.000000000 -0.07010000 2.010767e-01 1.674548e-07 FALSE TRUE
MSTRG.5477.3 ENSG00000110514 HEK293_OSMI2_2hA HEK293_TMG_2hB MADD protein_coding   20.8283 26.11796 13.95328 1.577113 0.7332933 -0.9039571 2.2887935 4.1076535 0.24309406 0.02959189 0.24309406 -4.02407685 0.10072917 0.15843333 0.018600000 -0.13983333 4.818612e-02 1.674548e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110514 E001 0.6717251 0.0289170059 1.136614e-01 2.108600e-01 11 47269161 47269283 123 + 0.361 0.095 -2.405
ENSG00000110514 E002 1.7273957 0.0133756907 9.416610e-01 9.673345e-01 11 47269376 47269644 269 + 0.436 0.433 -0.018
ENSG00000110514 E003 0.6642364 0.0560535198 5.665159e-01 6.934870e-01 11 47269672 47269673 2 + 0.271 0.173 -0.821
ENSG00000110514 E004 0.8157519 0.0156491400 2.693569e-01 4.078752e-01 11 47269674 47269676 3 + 0.361 0.173 -1.407
ENSG00000110514 E005 1.2702981 0.1090593178 4.751470e-02 1.047590e-01 11 47269677 47269683 7 + 0.557 0.173 -2.409
ENSG00000110514 E006 2.2990892 0.0155094278 3.413265e-02 8.002311e-02 11 47269684 47269692 9 + 0.690 0.348 -1.668
ENSG00000110514 E007 5.6958395 0.0681355699 1.555088e-01 2.690695e-01 11 47269693 47269750 58 + 0.923 0.701 -0.873
ENSG00000110514 E008 8.1807292 0.0199808765 8.575003e-04 3.464214e-03 11 47269751 47269906 156 + 1.172 0.769 -1.509
ENSG00000110514 E009 2.3070540 0.4579690753 2.712394e-01 4.099622e-01 11 47270141 47270146 6 + 0.605 0.437 -0.801
ENSG00000110514 E010 2.4585694 0.4474421323 2.133830e-01 3.425135e-01 11 47270147 47270147 1 + 0.650 0.437 -0.996
ENSG00000110514 E011 4.2686570 0.1235998231 9.336332e-02 1.803788e-01 11 47270148 47270155 8 + 0.875 0.572 -1.249
ENSG00000110514 E012 11.0043863 0.0152083724 5.836065e-02 1.238157e-01 11 47270156 47270246 91 + 1.172 0.972 -0.727
ENSG00000110514 E013 0.7708142 0.0153787590 4.358835e-02 9.762469e-02 11 47272244 47272330 87 + 0.436 0.095 -2.822
ENSG00000110514 E014 40.0266088 0.0084296705 4.381573e-06 3.158944e-05 11 47273827 47273976 150 + 1.764 1.456 -1.051
ENSG00000110514 E015 85.8259786 0.0118652972 1.062707e-05 7.019267e-05 11 47274563 47274909 347 + 2.069 1.804 -0.893
ENSG00000110514 E016 44.0046334 0.0137475851 1.321943e-03 5.049948e-03 11 47274910 47275005 96 + 1.764 1.533 -0.788
ENSG00000110514 E017 53.0624564 0.0004897016 7.374630e-08 7.684827e-07 11 47275006 47275159 154 + 1.852 1.604 -0.839
ENSG00000110514 E018 57.9136905 0.0004476980 2.427656e-08 2.784140e-07 11 47275899 47276027 129 + 1.890 1.644 -0.830
ENSG00000110514 E019 73.2207273 0.0029856937 4.290170e-03 1.395511e-02 11 47276028 47276202 175 + 1.918 1.792 -0.424
ENSG00000110514 E020 0.1482932 0.0415546881 8.529559e-01   11 47276705 47276731 27 + 0.000 0.095 13.221
ENSG00000110514 E021 60.9308945 0.0025502514 3.922038e-02 8.959153e-02 11 47276732 47276863 132 + 1.819 1.727 -0.312
ENSG00000110514 E022 49.6304537 0.0024202162 6.934686e-04 2.875116e-03 11 47278165 47278278 114 + 1.783 1.612 -0.581
ENSG00000110514 E023 43.9417707 0.0094500373 3.452096e-02 8.075238e-02 11 47278999 47279079 81 + 1.709 1.576 -0.452
ENSG00000110514 E024 67.8253993 0.0214873625 5.917208e-02 1.252106e-01 11 47281575 47281753 179 + 1.897 1.760 -0.462
ENSG00000110514 E025 97.7155947 0.0044499415 4.408951e-02 9.854676e-02 11 47282381 47282616 236 + 2.017 1.935 -0.274
ENSG00000110514 E026 87.7087777 0.0085341187 1.553847e-02 4.170871e-02 11 47282813 47282969 157 + 1.997 1.871 -0.423
ENSG00000110514 E027 71.7477579 0.0072678797 7.806468e-03 2.329215e-02 11 47284178 47284281 104 + 1.920 1.780 -0.472
ENSG00000110514 E028 94.0643811 0.0034784707 2.110019e-01 3.397216e-01 11 47284375 47284565 191 + 1.975 1.932 -0.146
ENSG00000110514 E029 28.4932307 0.0007455997 8.486477e-01 9.060331e-01 11 47284941 47284945 5 + 1.438 1.438 0.003
ENSG00000110514 E030 67.5402078 0.0004483472 2.200807e-01 3.505080e-01 11 47284946 47285065 120 + 1.833 1.792 -0.138
ENSG00000110514 E031 43.0291284 0.0004873584 1.002520e-02 2.882578e-02 11 47285066 47285194 129 + 1.694 1.568 -0.429
ENSG00000110514 E032 6.2021281 0.0053076483 6.726427e-01 7.785329e-01 11 47285271 47285450 180 + 0.849 0.806 -0.168
ENSG00000110514 E033 81.3483190 0.0003690956 7.191993e-02 1.465229e-01 11 47285451 47285590 140 + 1.922 1.863 -0.199
ENSG00000110514 E034 76.3654769 0.0004923861 2.327640e-03 8.236168e-03 11 47286433 47286534 102 + 1.929 1.816 -0.382
ENSG00000110514 E035 3.6944826 0.0412659170 5.339396e-01 6.660560e-01 11 47288968 47289027 60 + 0.690 0.599 -0.389
ENSG00000110514 E036 73.6294595 0.0003429857 1.099988e-01 2.055386e-01 11 47289391 47289493 103 + 1.877 1.823 -0.182
ENSG00000110514 E037 83.5496147 0.0004261769 4.356889e-01 5.778773e-01 11 47289867 47290053 187 + 1.862 1.909 0.157
ENSG00000110514 E038 0.2998086 0.0288955105 6.590064e-01   11 47290054 47290069 16 + 0.156 0.095 -0.825
ENSG00000110514 E039 88.2986233 0.0008856679 9.463452e-01 9.703312e-01 11 47290149 47290299 151 + 1.904 1.921 0.057
ENSG00000110514 E040 107.7198841 0.0017337782 9.461117e-01 9.701652e-01 11 47290610 47290816 207 + 1.997 2.008 0.040
ENSG00000110514 E041 0.2214452 0.0389835350 8.516898e-01   11 47292527 47292542 16 + 0.000 0.095 13.229
ENSG00000110514 E042 1.3984277 0.0098044992 1.459891e-01 2.562227e-01 11 47292543 47292596 54 + 0.156 0.433 1.985
ENSG00000110514 E043 68.4665545 0.0003813537 8.337458e-01 8.958774e-01 11 47293883 47293983 101 + 1.804 1.809 0.016
ENSG00000110514 E044 71.2967277 0.0016632774 7.733310e-01 8.537303e-01 11 47295496 47295567 72 + 1.804 1.832 0.094
ENSG00000110514 E045 37.1010582 0.0025665384 9.125505e-01 9.485703e-01 11 47295568 47295576 9 + 1.541 1.548 0.024
ENSG00000110514 E046 23.2746727 0.0096037326 5.607414e-01 6.886996e-01 11 47295577 47295579 3 + 1.302 1.369 0.234
ENSG00000110514 E047 127.1673986 0.0010541674 8.611129e-01 9.144199e-01 11 47295897 47296055 159 + 2.063 2.084 0.070
ENSG00000110514 E048 123.6215626 0.0034571265 9.964620e-01 1.000000e+00 11 47308591 47308699 109 + 2.055 2.069 0.049
ENSG00000110514 E049 0.0000000       11 47308980 47309042 63 +      
ENSG00000110514 E050 132.3692738 0.0004965564 4.593681e-01 5.995419e-01 11 47309281 47309401 121 + 2.068 2.107 0.131
ENSG00000110514 E051 115.1486888 0.0002748746 1.783156e-01 2.990284e-01 11 47309507 47309612 106 + 1.989 2.051 0.207
ENSG00000110514 E052 113.9193499 0.0003391658 3.055162e-02 7.305112e-02 11 47311732 47311842 111 + 1.963 2.055 0.310
ENSG00000110514 E053 106.4506413 0.0018932743 4.847080e-02 1.064579e-01 11 47315220 47315305 86 + 1.931 2.029 0.329
ENSG00000110514 E054 82.1912586 0.0005954584 2.861345e-02 6.923473e-02 11 47315306 47315327 22 + 1.813 1.922 0.365
ENSG00000110514 E055 136.0077369 0.0002970719 4.913094e-06 3.502826e-05 11 47323671 47323835 165 + 1.981 2.150 0.566
ENSG00000110514 E056 75.4363578 0.0015906425 4.941110e-04 2.137605e-03 11 47324265 47324303 39 + 1.713 1.897 0.621
ENSG00000110514 E057 66.9295059 0.0003977790 1.979530e-06 1.541436e-05 11 47324304 47324337 34 + 1.615 1.863 0.839
ENSG00000110514 E058 107.2728719 0.0002878577 1.924966e-06 1.502653e-05 11 47324471 47324577 107 + 1.857 2.054 0.660
ENSG00000110514 E059 8.4662084 0.0020680662 9.232352e-02 1.787527e-01 11 47324578 47325035 458 + 1.056 0.881 -0.651
ENSG00000110514 E060 3.7461453 0.2693891885 1.342925e-01 2.401211e-01 11 47325262 47325300 39 + 0.872 0.518 -1.490
ENSG00000110514 E061 2.6559532 0.0295939837 6.207789e-01 7.378563e-01 11 47326544 47326552 9 + 0.605 0.535 -0.320
ENSG00000110514 E062 83.8726744 0.0032198582 1.215791e-03 4.693961e-03 11 47326738 47326807 70 + 1.764 1.943 0.604
ENSG00000110514 E063 34.4698171 0.0492272339 5.788077e-01 7.038031e-01 11 47326808 47327186 379 + 1.564 1.495 -0.236
ENSG00000110514 E064 48.3286815 0.0121787508 9.522584e-02 1.832119e-01 11 47328142 47328657 516 + 1.730 1.625 -0.356
ENSG00000110514 E065 91.6308029 0.0058097428 2.801040e-04 1.298954e-03 11 47328658 47328704 47 + 1.777 1.992 0.725
ENSG00000110514 E066 496.9461836 0.0135531961 3.065212e-05 1.819677e-04 11 47329046 47330031 986 + 2.486 2.731 0.816