ENSG00000110455

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263776 ENSG00000110455 HEK293_OSMI2_2hA HEK293_TMG_2hB ACCS protein_coding protein_coding 4.296529 4.566695 3.245983 0.1262403 0.1805987 -0.4912131 1.5355217 2.43525714 1.65975966 0.49125173 0.07180722 -0.5503457 0.37173750 0.53440000 0.516066667 -0.01833333 0.96496537 0.01738393 FALSE  
ENST00000524990 ENSG00000110455 HEK293_OSMI2_2hA HEK293_TMG_2hB ACCS protein_coding protein_coding 4.296529 4.566695 3.245983 0.1262403 0.1805987 -0.4912131 0.1397156 0.04442890 0.26335945 0.04442890 0.13783745 2.3283545 0.03720417 0.01026667 0.077900000 0.06763333 0.47025749 0.01738393 FALSE  
ENST00000526577 ENSG00000110455 HEK293_OSMI2_2hA HEK293_TMG_2hB ACCS protein_coding retained_intron 4.296529 4.566695 3.245983 0.1262403 0.1805987 -0.4912131 0.2523714 0.07268927 0.21799352 0.04121675 0.02652818 1.4632209 0.05991667 0.01580000 0.066766667 0.05096667 0.01738393 0.01738393 TRUE  
ENST00000527346 ENSG00000110455 HEK293_OSMI2_2hA HEK293_TMG_2hB ACCS protein_coding retained_intron 4.296529 4.566695 3.245983 0.1262403 0.1805987 -0.4912131 0.6697447 0.46775198 0.42042048 0.11991279 0.05971632 -0.1505151 0.15196667 0.10253333 0.131066667 0.02853333 0.75339578 0.01738393 FALSE  
ENST00000531505 ENSG00000110455 HEK293_OSMI2_2hA HEK293_TMG_2hB ACCS protein_coding retained_intron 4.296529 4.566695 3.245983 0.1262403 0.1805987 -0.4912131 0.5745530 0.54951388 0.35145312 0.05654665 0.09470309 -0.6303654 0.12695000 0.11990000 0.107033333 -0.01286667 0.91604561 0.01738393 TRUE  
MSTRG.5408.6 ENSG00000110455 HEK293_OSMI2_2hA HEK293_TMG_2hB ACCS protein_coding   4.296529 4.566695 3.245983 0.1262403 0.1805987 -0.4912131 0.2580534 0.61477127 0.02471589 0.35748472 0.02471589 -4.1696600 0.06925000 0.13330000 0.007966667 -0.12533333 0.39012775 0.01738393 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110455 E001 0.0000000       11 44065925 44066012 88 +      
ENSG00000110455 E002 0.5953508 0.0335151717 0.5865095497 0.710070070 11 44066179 44066269 91 + 0.271 0.173 -0.824
ENSG00000110455 E003 4.5499183 0.0045343843 0.0059914293 0.018588121 11 44066270 44066322 53 + 0.943 0.567 -1.530
ENSG00000110455 E004 16.2423978 0.0050277638 0.0150853362 0.040680289 11 44066323 44066523 201 + 1.346 1.130 -0.762
ENSG00000110455 E005 7.2673517 0.0023977729 0.4745113140 0.613343874 11 44066524 44066535 12 + 0.943 0.853 -0.343
ENSG00000110455 E006 8.6294367 0.0058576434 0.2980149280 0.439406586 11 44066536 44066547 12 + 1.021 0.897 -0.465
ENSG00000110455 E007 17.5533808 0.0145673042 0.5941012058 0.716381460 11 44066548 44066701 154 + 1.262 1.209 -0.189
ENSG00000110455 E008 0.7780993 0.0671522092 0.4550149906 0.595587910 11 44067129 44067296 168 + 0.156 0.295 1.167
ENSG00000110455 E009 20.0695152 0.0010174194 0.1542941826 0.267489751 11 44067628 44067774 147 + 1.362 1.247 -0.402
ENSG00000110455 E010 11.6005516 0.0015831335 0.3979029220 0.541650606 11 44067775 44067778 4 + 1.131 1.043 -0.318
ENSG00000110455 E011 24.2644502 0.0021028056 0.2593140459 0.396697848 11 44067779 44067915 137 + 1.430 1.344 -0.298
ENSG00000110455 E012 17.1590817 0.0013038896 0.4880470004 0.625670204 11 44071256 44071315 60 + 1.272 1.209 -0.221
ENSG00000110455 E013 0.7437457 0.0157279202 0.0490007004 0.107381643 11 44073344 44073446 103 + 0.436 0.095 -2.820
ENSG00000110455 E014 14.0967421 0.0013508828 0.8734013641 0.922642286 11 44073447 44073517 71 + 1.158 1.138 -0.071
ENSG00000110455 E015 0.4396707 0.0253135999 0.0281566606 0.068324045 11 44073518 44073535 18 + 0.361 0.000 -12.947
ENSG00000110455 E016 11.4972065 0.0015027580 0.8358228842 0.897344814 11 44074612 44074629 18 + 1.056 1.071 0.057
ENSG00000110455 E017 16.6861091 0.0012031437 0.4679114717 0.607344948 11 44074630 44074681 52 + 1.171 1.229 0.205
ENSG00000110455 E018 11.5953769 0.0042454807 0.8346512774 0.896503164 11 44075526 44075530 5 + 1.056 1.072 0.058
ENSG00000110455 E019 18.0926946 0.0101607997 0.9673580860 0.983563326 11 44075531 44075592 62 + 1.252 1.243 -0.029
ENSG00000110455 E020 1.0436561 0.0200465361 0.0004021717 0.001782811 11 44075593 44075856 264 + 0.605 0.000 -14.098
ENSG00000110455 E021 16.7433258 0.0012440108 0.1936664713 0.318394102 11 44077279 44077322 44 + 1.131 1.242 0.392
ENSG00000110455 E022 21.6512990 0.0018013994 0.5013568974 0.637517603 11 44077323 44077376 54 + 1.282 1.330 0.167
ENSG00000110455 E023 9.7439821 0.0017419895 0.0127855403 0.035408398 11 44077377 44077844 468 + 1.158 0.896 -0.964
ENSG00000110455 E024 23.3371295 0.0009194663 0.5114567730 0.646485483 11 44077845 44077922 78 + 1.320 1.363 0.151
ENSG00000110455 E025 12.9786078 0.0015604620 0.0223528037 0.056413396 11 44077923 44078683 761 + 1.241 1.024 -0.779
ENSG00000110455 E026 26.3061916 0.0007644094 0.1978176538 0.323500894 11 44078684 44078784 101 + 1.346 1.431 0.295
ENSG00000110455 E027 9.2717157 0.0042667882 0.2220665896 0.352884649 11 44078785 44079337 553 + 1.072 0.934 -0.508
ENSG00000110455 E028 6.2311842 0.0026782466 0.6917241730 0.793155002 11 44079338 44079528 191 + 0.791 0.838 0.183
ENSG00000110455 E029 2.0887136 0.0086905925 0.1335330379 0.239049690 11 44079529 44079530 2 + 0.270 0.538 1.504
ENSG00000110455 E030 26.7739710 0.0007294322 0.0412253369 0.093294030 11 44079531 44079620 90 + 1.311 1.450 0.485
ENSG00000110455 E031 8.3316554 0.0022782048 0.7470065415 0.834635968 11 44080510 44081017 508 + 0.964 0.922 -0.158
ENSG00000110455 E032 2.2122156 0.0126776229 0.1354657466 0.241764838 11 44081018 44081019 2 + 0.271 0.539 1.508
ENSG00000110455 E033 22.0657524 0.0009910492 0.2575918713 0.394742222 11 44081020 44081065 46 + 1.272 1.354 0.285
ENSG00000110455 E034 1.6855640 0.0103728599 0.2619216156 0.399644529 11 44081066 44081178 113 + 0.270 0.471 1.181
ENSG00000110455 E035 30.8132124 0.0109608573 0.9526530946 0.974341407 11 44081179 44081320 142 + 1.483 1.473 -0.032
ENSG00000110455 E036 1.0975895 0.0205493484 0.7339460593 0.825054022 11 44082065 44082192 128 + 0.361 0.296 -0.405
ENSG00000110455 E037 30.1505762 0.0251525987 0.7578815647 0.842566511 11 44083169 44083311 143 + 1.490 1.454 -0.122
ENSG00000110455 E038 26.7804768 0.0011805583 0.0945711095 0.182242020 11 44083424 44083577 154 + 1.329 1.443 0.397
ENSG00000110455 E039 40.6861433 0.0007412017 0.0002154429 0.001030266 11 44083695 44084237 543 + 1.423 1.640 0.744