ENSG00000110429

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265651 ENSG00000110429 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO3 protein_coding protein_coding 17.50088 6.401561 27.38661 0.8466516 0.6269733 2.09525 9.833108 4.4286353 14.089722 0.2316958 0.87776538 1.667479 0.59480833 0.70523333 0.51413333 -0.19110000 0.05233612 0.0371599 FALSE TRUE
ENST00000448981 ENSG00000110429 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO3 protein_coding protein_coding 17.50088 6.401561 27.38661 0.8466516 0.6269733 2.09525 2.843335 0.1235426 4.000557 0.1235426 0.13665671 4.908431 0.12842083 0.02270000 0.14623333 0.12353333 0.08044865 0.0371599 FALSE TRUE
ENST00000530401 ENSG00000110429 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO3 protein_coding protein_coding 17.50088 6.401561 27.38661 0.8466516 0.6269733 2.09525 1.069207 0.7343706 1.611026 0.2558358 0.10687941 1.122814 0.08102500 0.10890000 0.05873333 -0.05016667 0.12391549 0.0371599 FALSE TRUE
ENST00000534136 ENSG00000110429 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO3 protein_coding protein_coding 17.50088 6.401561 27.38661 0.8466516 0.6269733 2.09525 1.105666 0.7758087 2.035578 0.3752649 0.09359566 1.380259 0.05745000 0.11103333 0.07426667 -0.03676667 0.69395354 0.0371599 FALSE TRUE
MSTRG.5365.8 ENSG00000110429 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO3 protein_coding   17.50088 6.401561 27.38661 0.8466516 0.6269733 2.09525 1.669857 0.2238409 3.789624 0.1131758 0.08183150 4.022257 0.07352917 0.03306667 0.13846667 0.10540000 0.03715990 0.0371599 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110429 E001 0.4417591 0.0290430581 1.230501e-01 2.243040e-01 11 33740939 33740943 5 - 0.070 0.343 2.774
ENSG00000110429 E002 1.2553328 0.0198633213 3.296083e-03 1.113826e-02 11 33740944 33740955 12 - 0.131 0.663 3.357
ENSG00000110429 E003 1.9487392 0.0075629972 1.872765e-05 1.169148e-04 11 33740956 33740964 9 - 0.131 0.846 4.098
ENSG00000110429 E004 117.7483046 0.0022390314 5.722358e-20 3.613612e-18 11 33740965 33741441 477 - 1.888 2.273 1.292
ENSG00000110429 E005 125.6419956 0.0016573196 1.860441e-08 2.182384e-07 11 33741442 33741738 297 - 1.974 2.211 0.797
ENSG00000110429 E006 153.9570975 0.0017246720 7.685610e-01 8.504142e-01 11 33741739 33742084 346 - 2.131 2.150 0.064
ENSG00000110429 E007 87.2688250 0.0178775783 5.212221e-03 1.650878e-02 11 33742085 33744684 2600 - 1.808 2.075 0.897
ENSG00000110429 E008 115.2206227 0.0428407586 3.084373e-02 7.361392e-02 11 33744685 33745766 1082 - 1.908 2.219 1.042
ENSG00000110429 E009 19.3604758 0.0035310899 2.865229e-02 6.931364e-02 11 33745767 33745936 170 - 1.197 1.419 0.773
ENSG00000110429 E010 17.2686523 0.0143596938 2.994241e-01 4.409181e-01 11 33745937 33746059 123 - 1.173 1.327 0.544
ENSG00000110429 E011 28.6789615 0.0085064402 2.612645e-01 3.989022e-01 11 33746060 33746655 596 - 1.434 1.367 -0.230
ENSG00000110429 E012 9.6418102 0.0380761277 2.629140e-01 4.007424e-01 11 33746656 33746742 87 - 1.013 0.848 -0.621
ENSG00000110429 E013 31.5360329 0.0006442300 2.298432e-01 3.622705e-01 11 33746743 33747129 387 - 1.474 1.420 -0.187
ENSG00000110429 E014 118.3786263 0.0003280026 6.270897e-02 1.312145e-01 11 33747130 33747241 112 - 2.033 1.996 -0.124
ENSG00000110429 E015 102.9818133 0.0002972955 7.331370e-03 2.208048e-02 11 33747242 33747320 79 - 1.982 1.906 -0.257
ENSG00000110429 E016 136.6677435 0.0002462592 3.523422e-05 2.058475e-04 11 33748777 33748892 116 - 2.112 1.997 -0.387
ENSG00000110429 E017 141.9672394 0.0003162385 9.873772e-05 5.159729e-04 11 33750539 33750661 123 - 2.127 2.022 -0.350
ENSG00000110429 E018 101.6148176 0.0003136951 2.111302e-02 5.383885e-02 11 33751523 33751607 85 - 1.974 1.912 -0.206
ENSG00000110429 E019 0.5848434 0.0222079472 3.213056e-01 4.645374e-01 11 33753111 33753342 232 - 0.231 0.000 -9.976
ENSG00000110429 E020 1.3318114 0.0096509060 5.515915e-02 1.182699e-01 11 33753343 33754454 1112 - 0.412 0.000 -11.147
ENSG00000110429 E021 78.5925579 0.0003797323 2.261064e-02 5.694274e-02 11 33754455 33754500 46 - 1.866 1.791 -0.250
ENSG00000110429 E022 129.7977276 0.0010367179 1.183328e-01 2.175493e-01 11 33755771 33755952 182 - 2.069 2.039 -0.098
ENSG00000110429 E023 56.9371749 0.0103296827 6.731212e-01 7.789051e-01 11 33755953 33755975 23 - 1.708 1.699 -0.029
ENSG00000110429 E024 53.5848055 0.0036142466 4.985632e-01 6.350223e-01 11 33758487 33758502 16 - 1.684 1.671 -0.043
ENSG00000110429 E025 102.3285946 0.0006774133 8.615819e-03 2.532727e-02 11 33758503 33758601 99 - 1.978 1.899 -0.263
ENSG00000110429 E026 0.7320925 0.0733124425 2.369143e-01 3.706006e-01 11 33763206 33763286 81 - 0.274 0.000 -10.297
ENSG00000110429 E027 0.0000000       11 33767608 33767635 28 -      
ENSG00000110429 E028 129.0546415 0.0010467201 5.530106e-04 2.357900e-03 11 33768851 33769014 164 - 2.084 1.980 -0.348
ENSG00000110429 E029 84.1093875 0.0010326985 1.627884e-03 6.050336e-03 11 33770741 33770815 75 - 1.905 1.787 -0.399
ENSG00000110429 E030 52.0782054 0.0060642758 1.776550e-01 2.981855e-01 11 33770816 33770830 15 - 1.688 1.627 -0.207
ENSG00000110429 E031 9.8855816 0.0169962388 3.970347e-01 5.408145e-01 11 33770831 33771832 1002 - 1.006 0.916 -0.337
ENSG00000110429 E032 22.7364538 0.0019431238 2.958772e-02 7.114956e-02 11 33771833 33774178 2346 - 1.354 1.190 -0.578
ENSG00000110429 E033 2.3731757 0.0078098180 2.527705e-01 3.891860e-01 11 33774179 33774347 169 - 0.539 0.343 -1.030
ENSG00000110429 E034 68.1794941 0.0111187345 3.596005e-02 8.350419e-02 11 33774394 33774543 150 - 1.817 1.689 -0.431