ENSG00000110427

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321505 ENSG00000110427 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549L protein_coding protein_coding 1.634374 1.353024 2.12846 0.1383518 0.09118894 0.6497614 0.1896539 0.3752872 0.3776023 0.12537037 0.01475519 0.008642669 0.1185417 0.2680333 0.1784667 -0.08956667 6.320374e-01 1.205674e-11 FALSE TRUE
ENST00000526400 ENSG00000110427 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549L protein_coding protein_coding 1.634374 1.353024 2.12846 0.1383518 0.09118894 0.6497614 0.2834445 0.0000000 0.5743852 0.00000000 0.05554797 5.868847772 0.1519917 0.0000000 0.2686333 0.26863333 6.211232e-09 1.205674e-11 FALSE TRUE
ENST00000658780 ENSG00000110427 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549L protein_coding protein_coding 1.634374 1.353024 2.12846 0.1383518 0.09118894 0.6497614 0.4577042 0.2096724 0.6113243 0.07645655 0.10122001 1.499992985 0.2695333 0.1489000 0.2846333 0.13573333 2.306581e-01 1.205674e-11 FALSE TRUE
MSTRG.5360.2 ENSG00000110427 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549L protein_coding   1.634374 1.353024 2.12846 0.1383518 0.09118894 0.6497614 0.1983519 0.4415087 0.0000000 0.01071508 0.00000000 -5.496682022 0.1455083 0.3351000 0.0000000 -0.33510000 1.205674e-11 1.205674e-11 FALSE TRUE
MSTRG.5360.4 ENSG00000110427 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549L protein_coding   1.634374 1.353024 2.12846 0.1383518 0.09118894 0.6497614 0.4652186 0.3027472 0.5651485 0.02092954 0.05475955 0.878937539 0.2908542 0.2299667 0.2683000 0.03833333 8.709593e-01 1.205674e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110427 E001 4.0944176 0.0039223721 2.350587e-02 5.878778e-02 11 33376108 33376465 358 + 0.823 0.512 -1.331
ENSG00000110427 E002 1.8339364 0.0978844186 7.874040e-02 1.574967e-01 11 33376466 33376673 208 + 0.583 0.243 -1.911
ENSG00000110427 E003 6.1195231 0.0027426710 3.841252e-03 1.269607e-02 11 33376674 33376889 216 + 0.990 0.640 -1.379
ENSG00000110427 E004 16.2012040 0.0011477649 3.589231e-06 2.641214e-05 11 33541802 33542146 345 + 1.379 0.999 -1.350
ENSG00000110427 E005 6.4141559 0.0025930138 3.618467e-01 5.062499e-01 11 33542147 33542330 184 + 0.907 0.821 -0.332
ENSG00000110427 E006 18.7711802 0.0210370477 3.721581e-03 1.235941e-02 11 33542331 33542920 590 + 1.399 1.129 -0.949
ENSG00000110427 E007 49.6951305 0.0005528037 8.664534e-05 4.593580e-04 11 33542921 33544336 1416 + 1.771 1.606 -0.559
ENSG00000110427 E008 4.7199694 0.0034946974 3.788872e-01 5.231876e-01 11 33544337 33544354 18 + 0.804 0.709 -0.384
ENSG00000110427 E009 36.9528104 0.0058937523 1.733551e-01 2.925609e-01 11 33544767 33545378 612 + 1.602 1.542 -0.204
ENSG00000110427 E010 14.9817082 0.0014877442 2.860797e-01 4.264588e-01 11 33547764 33547879 116 + 1.226 1.161 -0.231
ENSG00000110427 E011 20.5228007 0.0112340043 2.311371e-01 3.638286e-01 11 33551040 33551259 220 + 1.357 1.282 -0.262
ENSG00000110427 E012 18.2092335 0.0010686659 4.101555e-01 5.537657e-01 11 33552108 33552241 134 + 1.226 1.319 0.327
ENSG00000110427 E013 19.2418258 0.0159680745 3.960142e-01 5.397983e-01 11 33559749 33559911 163 + 1.241 1.353 0.393
ENSG00000110427 E014 12.0618228 0.0260472388 8.557817e-01 9.108110e-01 11 33561676 33561735 60 + 1.110 1.115 0.019
ENSG00000110427 E015 17.3803401 0.0085313381 6.342605e-02 1.324005e-01 11 33568076 33568227 152 + 1.146 1.345 0.699
ENSG00000110427 E016 17.0447632 0.0012031437 9.169814e-01 9.515713e-01 11 33574702 33574873 172 + 1.234 1.270 0.127
ENSG00000110427 E017 16.7669935 0.0088149587 5.514837e-01 6.809376e-01 11 33583338 33583501 164 + 1.261 1.233 -0.099
ENSG00000110427 E018 18.7405540 0.0013760089 1.455452e-01 2.556095e-01 11 33591237 33591421 185 + 1.330 1.243 -0.305
ENSG00000110427 E019 15.8483796 0.0012026947 7.350420e-02 1.491315e-01 11 33598820 33598947 128 + 1.275 1.150 -0.442
ENSG00000110427 E020 0.3299976 0.0274424043 1.485952e-01   11 33598948 33599494 547 + 0.000 0.243 9.730
ENSG00000110427 E021 19.2008733 0.0020985566 7.598377e-02 1.530856e-01 11 33606641 33606822 182 + 1.347 1.234 -0.395
ENSG00000110427 E022 22.8972560 0.0009234439 3.830959e-01 5.272644e-01 11 33609749 33609966 218 + 1.384 1.350 -0.118
ENSG00000110427 E023 16.8932357 0.0021022418 8.446377e-01 9.033148e-01 11 33618533 33618662 130 + 1.241 1.252 0.040
ENSG00000110427 E024 24.3774301 0.0096469213 7.239026e-01 8.176209e-01 11 33645686 33646036 351 + 1.368 1.426 0.198
ENSG00000110427 E025 11.3729537 0.0015734252 2.660943e-01 4.042467e-01 11 33656012 33656109 98 + 1.014 1.150 0.491
ENSG00000110427 E026 14.6265877 0.0015802285 1.299100e-01 2.340393e-01 11 33658750 33658898 149 + 1.110 1.270 0.568
ENSG00000110427 E027 17.2190440 0.0213102448 4.655114e-01 6.052112e-01 11 33660863 33661014 152 + 1.211 1.316 0.368
ENSG00000110427 E028 232.7035659 0.0047267756 4.999797e-07 4.421813e-06 11 33667873 33674102 6230 + 2.273 2.452 0.597