ENSG00000110395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264033 ENSG00000110395 HEK293_OSMI2_2hA HEK293_TMG_2hB CBL protein_coding protein_coding 6.533569 5.551908 7.151181 0.3566635 0.1525576 0.3646175 6.1041347 5.464699 6.1035987 0.3359054 0.1682812 0.1592423 0.9360792 0.9846333 0.85336667 -0.13126667 1.508022e-09 1.508022e-09 FALSE TRUE
ENST00000634840 ENSG00000110395 HEK293_OSMI2_2hA HEK293_TMG_2hB CBL protein_coding protein_coding 6.533569 5.551908 7.151181 0.3566635 0.1525576 0.3646175 0.2839854 0.000000 0.6594102 0.0000000 0.1133767 6.0648186 0.0421625 0.0000000 0.09296667 0.09296667 6.199513e-08 1.508022e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110395 E001 0.8814178 0.4001856951 8.280229e-02 1.639365e-01 11 119206298 119206299 2 + 0.409 0.000 -10.556
ENSG00000110395 E002 1.1738395 0.3433049139 3.661496e-02 8.474143e-02 11 119206300 119206311 12 + 0.489 0.000 -12.782
ENSG00000110395 E003 3.4729313 0.0606211746 8.969544e-04 3.603472e-03 11 119206312 119206338 27 + 0.812 0.258 -2.755
ENSG00000110395 E004 8.0446842 0.0148145650 2.550258e-05 1.543032e-04 11 119206339 119206400 62 + 1.096 0.629 -1.819
ENSG00000110395 E005 7.4275755 0.0032471019 6.184070e-06 4.313049e-05 11 119206401 119206423 23 + 1.068 0.584 -1.914
ENSG00000110395 E006 27.1293378 0.0009397693 6.309442e-09 8.081298e-08 11 119206424 119206612 189 + 1.550 1.256 -1.016
ENSG00000110395 E007 41.7656795 0.0005096548 2.686349e-20 1.775098e-18 11 119232448 119232695 248 + 1.767 1.336 -1.473
ENSG00000110395 E008 32.2581892 0.0006732029 1.935510e-11 3.844778e-10 11 119271735 119271881 147 + 1.631 1.311 -1.101
ENSG00000110395 E009 38.8014638 0.0005374533 1.363976e-14 4.407321e-13 11 119273868 119274024 157 + 1.713 1.368 -1.183
ENSG00000110395 E010 18.5083144 0.0023579371 2.737602e-10 4.483320e-09 11 119274832 119274851 20 + 1.429 0.979 -1.601
ENSG00000110395 E011 30.9878902 0.0006238666 2.534197e-19 1.500769e-17 11 119274852 119274953 102 + 1.659 1.145 -1.782
ENSG00000110395 E012 36.8636420 0.0005856923 1.024311e-19 6.304506e-18 11 119275997 119276134 138 + 1.724 1.266 -1.575
ENSG00000110395 E013 28.2960419 0.0007931959 7.079898e-09 8.974526e-08 11 119277757 119277844 88 + 1.565 1.285 -0.970
ENSG00000110395 E014 33.9209388 0.0011845165 2.629785e-10 4.313462e-09 11 119278166 119278297 132 + 1.642 1.352 -0.993
ENSG00000110395 E015 32.6753047 0.0387854421 3.366023e-04 1.526799e-03 11 119278510 119278713 204 + 1.625 1.341 -0.978
ENSG00000110395 E016 24.5390756 0.0242098919 3.072403e-06 2.293100e-05 11 119284969 119285100 132 + 1.530 1.149 -1.328
ENSG00000110395 E017 61.5520048 0.0018821835 1.306925e-26 1.633199e-24 11 119285189 119285566 378 + 1.938 1.486 -1.531
ENSG00000110395 E018 32.4030637 0.0006362596 1.044056e-12 2.554479e-11 11 119287852 119287946 95 + 1.642 1.293 -1.199
ENSG00000110395 E019 36.5757902 0.0007782221 3.021610e-10 4.914870e-09 11 119296918 119297034 117 + 1.669 1.404 -0.909
ENSG00000110395 E020 26.8329856 0.0324301534 9.526907e-05 4.998045e-04 11 119297384 119297481 98 + 1.554 1.236 -1.101
ENSG00000110395 E021 16.5271878 0.0114914496 3.161965e-04 1.445488e-03 11 119298358 119298371 14 + 1.335 1.091 -0.865
ENSG00000110395 E022 37.4040070 0.0006201179 2.395732e-09 3.311428e-08 11 119298372 119298540 169 + 1.669 1.431 -0.815
ENSG00000110395 E023 29.8013090 0.0220548705 1.415753e-04 7.103749e-04 11 119299495 119299587 93 + 1.574 1.318 -0.882
ENSG00000110395 E024 22.0565483 0.0402420677 1.042376e-02 2.980321e-02 11 119299588 119299635 48 + 1.428 1.236 -0.672
ENSG00000110395 E025 1040.8419651 0.0044492107 9.795178e-02 1.873881e-01 11 119299636 119306287 6652 + 2.974 3.061 0.289
ENSG00000110395 E026 71.3296154 0.0136183446 3.416755e-07 3.125213e-06 11 119306288 119306380 93 + 1.583 2.061 1.614
ENSG00000110395 E027 384.9012178 0.0093295593 5.716498e-20 3.613525e-18 11 119306381 119307478 1098 + 2.272 2.803 1.769
ENSG00000110395 E028 216.6247015 0.0032231379 8.028242e-75 1.382660e-71 11 119307479 119308069 591 + 1.802 2.615 2.720
ENSG00000110395 E029 15.1977284 0.0113102116 3.106788e-17 1.423046e-15 11 119308070 119308149 80 + 0.409 1.532 4.400
ENSG00000110395 E030 0.3729606 0.0257674598 9.017197e-01 9.413884e-01 11 119313418 119313421 4 + 0.101 0.148 0.638
ENSG00000110395 E031 4.0169174 0.0039892541 4.308105e-02 9.670227e-02 11 119313422 119313926 505 + 0.490 0.874 1.635