ENSG00000110330

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000227758 ENSG00000110330 HEK293_OSMI2_2hA HEK293_TMG_2hB BIRC2 protein_coding protein_coding 9.999807 5.573213 15.22932 0.3924663 1.078956 1.448631 6.2640755 1.0371365 10.90206045 0.2009351 1.02259221 3.381402 0.50343333 0.18553333 0.715833333 0.530300000 2.131150e-09 2.13115e-09 FALSE TRUE
ENST00000531259 ENSG00000110330 HEK293_OSMI2_2hA HEK293_TMG_2hB BIRC2 protein_coding protein_coding 9.999807 5.573213 15.22932 0.3924663 1.078956 1.448631 0.2040935 0.7948386 0.00000000 0.4003633 0.00000000 -6.330628 0.03844583 0.15313333 0.000000000 -0.153133333 8.548707e-02 2.13115e-09 FALSE TRUE
ENST00000532832 ENSG00000110330 HEK293_OSMI2_2hA HEK293_TMG_2hB BIRC2 protein_coding protein_coding 9.999807 5.573213 15.22932 0.3924663 1.078956 1.448631 0.3400762 1.1245882 0.00000000 0.5995384 0.00000000 -6.826025 0.07175417 0.18833333 0.000000000 -0.188333333 9.377508e-02 2.13115e-09 FALSE FALSE
ENST00000533742 ENSG00000110330 HEK293_OSMI2_2hA HEK293_TMG_2hB BIRC2 protein_coding protein_coding 9.999807 5.573213 15.22932 0.3924663 1.078956 1.448631 0.4111274 0.0000000 1.06946151 0.0000000 0.54650915 6.754168 0.03015417 0.00000000 0.066600000 0.066600000 9.785446e-04 2.13115e-09 FALSE FALSE
ENST00000534646 ENSG00000110330 HEK293_OSMI2_2hA HEK293_TMG_2hB BIRC2 protein_coding processed_transcript 9.999807 5.573213 15.22932 0.3924663 1.078956 1.448631 0.1876284 0.4738757 0.00000000 0.4738757 0.00000000 -5.596565 0.03662083 0.07596667 0.000000000 -0.075966667 6.494309e-01 2.13115e-09 FALSE FALSE
MSTRG.6218.10 ENSG00000110330 HEK293_OSMI2_2hA HEK293_TMG_2hB BIRC2 protein_coding   9.999807 5.573213 15.22932 0.3924663 1.078956 1.448631 0.8589501 0.7713784 2.22464958 0.5189498 0.40600757 1.515955 0.09456250 0.14256667 0.147533333 0.004966667 8.488863e-01 2.13115e-09 FALSE TRUE
MSTRG.6218.2 ENSG00000110330 HEK293_OSMI2_2hA HEK293_TMG_2hB BIRC2 protein_coding   9.999807 5.573213 15.22932 0.3924663 1.078956 1.448631 0.7178207 1.3084154 0.08265047 0.6871921 0.08265047 -3.830863 0.14205833 0.24436667 0.006266667 -0.238100000 2.569669e-01 2.13115e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110330 E001 0.2214452 0.0398302672 1.210906e-01   11 102347211 102347213 3 + 0.000 0.225 10.852
ENSG00000110330 E002 0.2214452 0.0398302672 1.210906e-01   11 102347214 102347216 3 + 0.000 0.225 13.201
ENSG00000110330 E003 0.2214452 0.0398302672 1.210906e-01   11 102347217 102347223 7 + 0.000 0.225 13.201
ENSG00000110330 E004 0.5149111 0.0202549959 9.569547e-02 1.839310e-01 11 102347224 102347226 3 + 0.063 0.372 3.114
ENSG00000110330 E005 2.2036988 0.1432712711 2.237692e-02 5.645997e-02 11 102347227 102347228 2 + 0.287 0.800 2.502
ENSG00000110330 E006 17.8071197 0.0341208931 1.323208e-11 2.701852e-10 11 102347229 102347246 18 + 0.821 1.685 3.076
ENSG00000110330 E007 20.8568464 0.0295660215 1.236157e-12 2.988594e-11 11 102347247 102347252 6 + 0.896 1.743 2.983
ENSG00000110330 E008 27.9351610 0.0189916674 1.315812e-15 4.905088e-14 11 102347253 102347268 16 + 1.048 1.849 2.778
ENSG00000110330 E009 57.4339179 0.0089578034 1.020328e-17 5.012307e-16 11 102347269 102347373 105 + 1.460 2.075 2.083
ENSG00000110330 E010 46.6539290 0.0063305815 2.654196e-21 1.965713e-19 11 102347374 102347376 3 + 1.345 2.011 2.265
ENSG00000110330 E011 4.9434710 0.0364915237 1.984817e-01 3.243041e-01 11 102347377 102347845 469 + 0.743 0.568 -0.749
ENSG00000110330 E012 2.1070058 0.2588991855 3.110338e-01 4.534771e-01 11 102348281 102348407 127 + 0.482 0.225 -1.584
ENSG00000110330 E013 66.7471004 0.0062567389 1.649397e-11 3.315015e-10 11 102348598 102348719 122 + 1.603 2.057 1.533
ENSG00000110330 E014 20.2050859 0.0011369563 9.217255e-03 2.682759e-02 11 102348720 102348764 45 + 1.282 1.097 -0.657
ENSG00000110330 E015 175.7445398 0.0003068841 6.944119e-32 1.324816e-29 11 102348765 102349877 1113 + 2.221 1.858 -1.216
ENSG00000110330 E016 49.7577707 0.0026545235 2.491979e-07 2.344780e-06 11 102349878 102349973 96 + 1.671 1.369 -1.035
ENSG00000110330 E017 19.3239066 0.0009766220 1.019166e-02 2.923741e-02 11 102349974 102349974 1 + 1.260 1.073 -0.668
ENSG00000110330 E018 29.2436178 0.0011568614 3.224514e-04 1.470675e-03 11 102349975 102350000 26 + 1.438 1.201 -0.827
ENSG00000110330 E019 104.1033369 0.0014633896 2.832713e-09 3.863563e-08 11 102350001 102350345 345 + 1.975 1.763 -0.713
ENSG00000110330 E020 125.2502595 0.0008721396 8.391763e-07 7.085592e-06 11 102350346 102350745 400 + 2.042 1.915 -0.424
ENSG00000110330 E021 35.9535018 0.0011875359 7.442498e-04 3.058346e-03 11 102350746 102350749 4 + 1.524 1.342 -0.627
ENSG00000110330 E022 64.2251986 0.0003749016 3.885121e-06 2.834134e-05 11 102350844 102350943 100 + 1.769 1.582 -0.633
ENSG00000110330 E023 0.0000000       11 102362742 102362895 154 +      
ENSG00000110330 E024 65.7358177 0.0003822767 3.245890e-05 1.914761e-04 11 102362896 102362974 79 + 1.773 1.619 -0.523
ENSG00000110330 E025 58.8040802 0.0016142322 6.322121e-05 3.472017e-04 11 102363668 102363716 49 + 1.729 1.558 -0.580
ENSG00000110330 E026 111.2506607 0.0003426659 3.221957e-06 2.394532e-05 11 102368306 102368548 243 + 1.992 1.874 -0.398
ENSG00000110330 E027 105.8738512 0.0128904879 5.374294e-01 6.689952e-01 11 102377496 102377750 255 + 1.938 1.977 0.133
ENSG00000110330 E028 47.6326753 0.0018550853 9.148283e-01 9.500656e-01 11 102377857 102377898 42 + 1.590 1.672 0.279
ENSG00000110330 E029 154.1344868 0.0211741873 5.523789e-03 1.734914e-02 11 102377990 102378670 681 + 2.030 2.311 0.941