ENSG00000110318

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263468 ENSG00000110318 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP126 protein_coding protein_coding 0.3391631 0.10962 0.4889122 0.007547019 0.05218915 2.060327 0.19152472 0.04093157 0.2607072 0.04093157 0.05753961 2.410101 0.47552500 0.3333333 0.5218333 0.1885000 0.72094590 0.02965218 FALSE TRUE
ENST00000532529 ENSG00000110318 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP126 protein_coding nonsense_mediated_decay 0.3391631 0.10962 0.4889122 0.007547019 0.05218915 2.060327 0.08666479 0.00000000 0.2282050 0.00000000 0.01467000 4.574132 0.28048750 0.0000000 0.4781667 0.4781667 0.02965218 0.02965218 FALSE TRUE
ENST00000670091 ENSG00000110318 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP126 protein_coding nonsense_mediated_decay 0.3391631 0.10962 0.4889122 0.007547019 0.05218915 2.060327 0.04401172 0.03221785 0.0000000 0.03221785 0.00000000 -2.077853 0.15959167 0.3333333 0.0000000 -0.3333333 0.68731710 0.02965218 FALSE TRUE
ENST00000670318 ENSG00000110318 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP126 protein_coding nonsense_mediated_decay 0.3391631 0.10962 0.4889122 0.007547019 0.05218915 2.060327 0.01202816 0.03647057 0.0000000 0.03647057 0.00000000 -2.216317 0.06170833 0.3333333 0.0000000 -0.3333333 0.69851751 0.02965218 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110318 E001 0.0000000       11 101915010 101915011 2 +      
ENSG00000110318 E002 0.4418608 0.024441170 0.632245603 0.747126211 11 101915012 101915053 42 + 0.172 0.000 -9.607
ENSG00000110318 E003 1.6607648 0.009132097 0.347046527 0.491215240 11 101915054 101915412 359 + 0.419 0.218 -1.319
ENSG00000110318 E004 1.0663564 0.012127966 0.558135385 0.686419939 11 101922641 101922760 120 + 0.258 0.362 0.680
ENSG00000110318 E005 1.1373435 0.017357547 0.028442688 0.068897210 11 101944265 101944374 110 + 0.173 0.557 2.417
ENSG00000110318 E006 1.0558610 0.028237295 0.549020873 0.678792984 11 101944375 101944410 36 + 0.258 0.362 0.680
ENSG00000110318 E007 1.9564208 0.008133366 0.709068790 0.806550316 11 101948031 101948142 112 + 0.445 0.362 -0.457
ENSG00000110318 E008 1.7894782 0.053774869 0.303351968 0.445253073 11 101955792 101956261 470 + 0.446 0.217 -1.463
ENSG00000110318 E009 2.3552934 0.006451638 0.131740801 0.236545346 11 101956262 101956867 606 + 0.536 0.218 -1.905
ENSG00000110318 E010 0.9201396 0.019009822 0.876964365 0.925004833 11 101956868 101956943 76 + 0.258 0.218 -0.319
ENSG00000110318 E011 3.8848307 0.005152141 0.017168718 0.045317349 11 101958168 101958366 199 + 0.705 0.218 -2.641
ENSG00000110318 E012 21.6677717 0.001047325 0.031446516 0.074778432 11 101961741 101963880 2140 + 1.319 1.127 -0.679
ENSG00000110318 E013 2.8786116 0.031374945 0.081980882 0.162655860 11 101978347 101978401 55 + 0.594 0.218 -2.164
ENSG00000110318 E014 2.7292862 0.005888079 0.088037663 0.172141764 11 101978402 101978459 58 + 0.576 0.218 -2.084
ENSG00000110318 E015 1.9251877 0.007797236 0.033660135 0.079077526 11 101981889 101981964 76 + 0.493 0.000 -12.738
ENSG00000110318 E016 3.7329940 0.023433163 0.034763215 0.081192713 11 101986832 101987041 210 + 0.515 0.837 1.367
ENSG00000110318 E017 3.2451502 0.005060177 0.008288866 0.024514501 11 101992778 101992842 65 + 0.445 0.837 1.713
ENSG00000110318 E018 19.3094075 0.001662365 0.001956036 0.007089745 11 101997599 102001062 3464 + 1.180 1.388 0.730