ENSG00000110315

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265981 ENSG00000110315 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF141 protein_coding protein_coding 8.545002 5.034246 12.85362 0.7530063 0.5970693 1.350586 7.1116857 3.3256836 12.0544742 0.6709780 0.3592472 1.854711 0.7784375 0.6526333 0.93943333 0.2868000 2.679526e-05 2.679526e-05 FALSE TRUE
ENST00000528665 ENSG00000110315 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF141 protein_coding protein_coding 8.545002 5.034246 12.85362 0.7530063 0.5970693 1.350586 0.6405760 1.2729789 0.5354668 0.3088100 0.2487764 -1.233934 0.1018250 0.2558667 0.04003333 -0.2158333 1.544790e-02 2.679526e-05 FALSE TRUE
ENST00000533412 ENSG00000110315 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF141 protein_coding protein_coding 8.545002 5.034246 12.85362 0.7530063 0.5970693 1.350586 0.6417515 0.4050622 0.0000000 0.4050622 0.0000000 -5.375256 0.1037125 0.0857000 0.00000000 -0.0857000 6.761373e-01 2.679526e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110315 E001 3.7953730 0.0042566333 6.489766e-03 1.989686e-02 11 10511673 10511922 250 - 0.512 0.879 1.545
ENSG00000110315 E002 559.8880515 0.0014596618 5.647338e-20 3.572191e-18 11 10511923 10515066 3144 - 2.795 2.614 -0.603
ENSG00000110315 E003 5.9755083 0.0027532487 4.757129e-01 6.144024e-01 11 10515067 10517740 2674 - 0.877 0.756 -0.475
ENSG00000110315 E004 4.8683606 0.0714454238 7.893706e-02 1.578216e-01 11 10518318 10519033 716 - 0.641 0.904 1.057
ENSG00000110315 E005 120.3151213 0.0002512651 1.889976e-09 2.659118e-08 11 10519034 10519141 108 - 2.012 2.170 0.529
ENSG00000110315 E006 161.5685768 0.0003077095 2.402062e-06 1.836340e-05 11 10525192 10525373 182 - 2.164 2.262 0.327
ENSG00000110315 E007 126.3003382 0.0004132327 4.983986e-05 2.810039e-04 11 10530643 10530751 109 - 2.058 2.155 0.323
ENSG00000110315 E008 0.4439371 0.0215863611 3.166563e-01 4.594474e-01 11 10531827 10532015 189 - 0.224 0.000 -12.012
ENSG00000110315 E009 130.9561689 0.0002527280 1.438694e-02 3.910364e-02 11 10534016 10534205 190 - 2.094 2.139 0.149
ENSG00000110315 E010 0.1817044 0.0503365536 2.100778e-01   11 10540753 10541121 369 - 0.000 0.167 10.814
ENSG00000110315 E011 54.3723812 0.0007259549 7.579812e-01 8.426476e-01 11 10541122 10541230 109 - 1.737 1.722 -0.053