ENSG00000110274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000528706 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding retained_intron 13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 1.2739940 1.3259732 0.8177682 0.2328306 0.03029034 -0.6905924 0.09629583 0.07923333 0.10186667 0.02263333 0.62764383 0.02764126 FALSE FALSE
ENST00000533433 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding retained_intron 13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 2.2695624 3.4081574 1.0515774 0.2404748 0.20369324 -1.6870093 0.16629583 0.20266667 0.13153333 -0.07113333 0.28042688 0.02764126 FALSE FALSE
ENST00000533706 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding processed_transcript 13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 0.8003032 1.0884975 0.4018875 0.1189815 0.04972644 -1.4152093 0.06060000 0.06473333 0.04960000 -0.01513333 0.63360414 0.02764126 TRUE TRUE
MSTRG.6384.11 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding   13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 0.1622866 0.0000000 0.4133528 0.0000000 0.41335275 5.4037884 0.01991250 0.00000000 0.05516667 0.05516667 0.74110667 0.02764126 FALSE TRUE
MSTRG.6384.13 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding   13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 0.4662444 0.0000000 0.8313722 0.0000000 0.44317932 6.3946722 0.03865417 0.00000000 0.10003333 0.10003333 0.11395087 0.02764126 FALSE TRUE
MSTRG.6384.15 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding   13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 0.9885173 2.0379502 0.0000000 1.0315945 0.00000000 -7.6780368 0.07010833 0.12343333 0.00000000 -0.12343333 0.22557922 0.02764126 FALSE TRUE
MSTRG.6384.17 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding   13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 1.2539892 1.6796814 0.5127422 1.0921498 0.51274222 -1.6925796 0.10146250 0.09803333 0.06023333 -0.03780000 0.63354066 0.02764126 FALSE TRUE
MSTRG.6384.18 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding   13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 0.1576468 0.1430660 0.7904882 0.1430660 0.45521348 2.3867262 0.01695417 0.00900000 0.09533333 0.08633333 0.42752594 0.02764126 FALSE TRUE
MSTRG.6384.19 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding   13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 1.0539220 0.7930118 0.7340260 0.7930118 0.36758726 -0.1100682 0.07590833 0.04503333 0.09190000 0.04686667 0.52547052 0.02764126 FALSE TRUE
MSTRG.6384.6 ENSG00000110274 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP164 protein_coding   13.13862 16.8549 8.064514 0.5059707 0.3003398 -1.062576 1.9497155 3.3798157 0.1338033 0.7442693 0.13380328 -4.5590384 0.12978750 0.20210000 0.01633333 -0.18576667 0.02764126 0.02764126 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110274 E001 0.1515154 0.0430869446 2.159482e-01   11 117314557 117314728 172 + 0.172 0.000 -10.666
ENSG00000110274 E002 0.5503986 0.0209058592 9.225867e-01 9.551698e-01 11 117327847 117327849 3 + 0.172 0.157 -0.154
ENSG00000110274 E003 1.2094382 0.0396719638 1.685964e-01 2.863400e-01 11 117327850 117327853 4 + 0.469 0.220 -1.562
ENSG00000110274 E004 1.7608810 0.0134205105 5.423362e-01 6.731130e-01 11 117327854 117327874 21 + 0.469 0.364 -0.568
ENSG00000110274 E005 2.7896590 0.1020026586 3.962995e-01 5.400850e-01 11 117327875 117327904 30 + 0.643 0.478 -0.759
ENSG00000110274 E006 1.5373595 0.0227073967 4.017507e-01 5.454501e-01 11 117327905 117327918 14 + 0.469 0.321 -0.830
ENSG00000110274 E007 1.5373595 0.0227073967 4.017507e-01 5.454501e-01 11 117327919 117327928 10 + 0.469 0.321 -0.830
ENSG00000110274 E008 1.8371681 0.0076769059 3.092403e-01 4.515090e-01 11 117327929 117328009 81 + 0.535 0.363 -0.893
ENSG00000110274 E009 0.6266857 0.0168000244 4.238476e-01 5.668734e-01 11 117328010 117328016 7 + 0.295 0.157 -1.158
ENSG00000110274 E010 0.4783925 0.0213339175 2.044971e-01 3.317892e-01 11 117328017 117328029 13 + 0.295 0.086 -2.156
ENSG00000110274 E011 0.6621732 0.0653688403 4.369677e-01 5.789939e-01 11 117328030 117328043 14 + 0.295 0.157 -1.155
ENSG00000110274 E012 0.9911266 0.3212243566 3.960170e-01 5.397983e-01 11 117328044 117328046 3 + 0.391 0.220 -1.146
ENSG00000110274 E013 1.1394198 0.0744354846 5.222022e-01 6.560485e-01 11 117328047 117328051 5 + 0.391 0.272 -0.744
ENSG00000110274 E014 1.5060377 0.0092994489 3.908330e-01 5.347810e-01 11 117328052 117328053 2 + 0.469 0.320 -0.834
ENSG00000110274 E015 4.9809781 0.0036914960 4.223731e-02 9.515449e-02 11 117328054 117328084 31 + 0.918 0.652 -1.064
ENSG00000110274 E016 5.7538661 0.0028198561 1.329293e-01 2.381872e-01 11 117328085 117328102 18 + 0.918 0.729 -0.742
ENSG00000110274 E017 7.8844986 0.0022727947 1.620790e-01 2.778290e-01 11 117328103 117328118 16 + 1.010 0.852 -0.597
ENSG00000110274 E018 22.4480363 0.0050455441 3.554774e-03 1.188293e-02 11 117328119 117328208 90 + 1.472 1.245 -0.789
ENSG00000110274 E019 21.9956830 0.0063004690 2.031744e-03 7.325386e-03 11 117335605 117335680 76 + 1.479 1.233 -0.854
ENSG00000110274 E020 35.8535183 0.0019734361 6.624167e-05 3.619221e-04 11 117338566 117338668 103 + 1.678 1.437 -0.822
ENSG00000110274 E021 41.7315547 0.0012842358 4.405782e-06 3.175311e-05 11 117344166 117344277 112 + 1.747 1.493 -0.867
ENSG00000110274 E022 53.2813888 0.0007352977 6.399049e-06 4.446778e-05 11 117351790 117351988 199 + 1.830 1.609 -0.746
ENSG00000110274 E023 3.8914539 0.0501913105 3.082260e-01 4.504923e-01 11 117354932 117355978 1047 + 0.768 0.606 -0.678
ENSG00000110274 E024 2.4145465 0.0482334711 8.801972e-01 9.271583e-01 11 117355979 117356617 639 + 0.469 0.504 0.173
ENSG00000110274 E025 2.6707942 0.1034341979 2.506742e-04 1.178136e-03 11 117359432 117359560 129 + 0.919 0.216 -3.504
ENSG00000110274 E026 45.4200504 0.0044731312 5.796007e-06 4.066048e-05 11 117361835 117361993 159 + 1.794 1.525 -0.914
ENSG00000110274 E027 59.4945640 0.0047502358 1.450076e-03 5.473996e-03 11 117362404 117362538 135 + 1.851 1.677 -0.587
ENSG00000110274 E028 33.3190347 0.0020034681 2.408927e-02 5.999579e-02 11 117363429 117363506 78 + 1.584 1.444 -0.481
ENSG00000110274 E029 0.4438354 0.1219168105 9.025002e-01 9.418959e-01 11 117363955 117364043 89 + 0.172 0.155 -0.176
ENSG00000110274 E030 128.6238464 0.0002828468 4.711010e-05 2.671396e-04 11 117371080 117371466 387 + 2.149 2.022 -0.425
ENSG00000110274 E031 52.7071014 0.0100238685 2.028676e-01 3.298139e-01 11 117373751 117373831 81 + 1.736 1.652 -0.286
ENSG00000110274 E032 47.6086115 0.0073270976 3.400952e-01 4.840468e-01 11 117375708 117375791 84 + 1.674 1.617 -0.195
ENSG00000110274 E033 50.7720934 0.0115832450 6.145158e-01 7.329526e-01 11 117380614 117380705 92 + 1.678 1.651 -0.091
ENSG00000110274 E034 1.7286157 0.0190106908 2.177345e-01 3.476666e-01 11 117380706 117380714 9 + 0.535 0.321 -1.152
ENSG00000110274 E035 67.4083175 0.0096898298 6.541749e-01 7.644475e-01 11 117381701 117381868 168 + 1.794 1.774 -0.069
ENSG00000110274 E036 0.6579068 0.4564351810 5.482038e-01 6.780722e-01 11 117382732 117382795 64 + 0.295 0.158 -1.143
ENSG00000110274 E037 7.9732294 0.0135110714 3.546592e-01 4.989909e-01 11 117382796 117382904 109 + 0.989 0.877 -0.422
ENSG00000110274 E038 6.6478519 0.0411383566 4.682763e-01 6.077019e-01 11 117382905 117382942 38 + 0.919 0.808 -0.426
ENSG00000110274 E039 6.5185899 0.0851238647 1.061497e-01 1.998443e-01 11 117384597 117387202 2606 + 1.011 0.754 -0.984
ENSG00000110274 E040 75.4779096 0.0006135792 2.130609e-01 3.421526e-01 11 117387203 117387412 210 + 1.863 1.814 -0.165
ENSG00000110274 E041 82.8041198 0.0017537753 7.888669e-01 8.648539e-01 11 117390777 117390908 132 + 1.871 1.866 -0.019
ENSG00000110274 E042 113.9811035 0.0013056115 4.622278e-01 6.020837e-01 11 117390999 117391215 217 + 1.979 2.015 0.121
ENSG00000110274 E043 69.9737483 0.0008199440 8.394498e-01 8.996761e-01 11 117392226 117392303 78 + 1.787 1.803 0.055
ENSG00000110274 E044 91.8974350 0.0003061316 6.505506e-01 7.615832e-01 11 117392496 117392627 132 + 1.896 1.921 0.084
ENSG00000110274 E045 93.2231128 0.0003814820 4.530776e-01 5.938438e-01 11 117393004 117393126 123 + 1.896 1.933 0.125
ENSG00000110274 E046 96.4258980 0.0057662302 9.910154e-01 9.985050e-01 11 117394350 117394493 144 + 1.935 1.941 0.023
ENSG00000110274 E047 40.4529398 0.0165027639 3.079946e-01 4.502280e-01 11 117394920 117394924 5 + 1.626 1.551 -0.255
ENSG00000110274 E048 60.5066414 0.0127181031 3.944359e-01 5.382693e-01 11 117394925 117395003 79 + 1.780 1.727 -0.178
ENSG00000110274 E049 1.7475447 0.0247320305 3.112177e-02 7.414020e-02 11 117395004 117395122 119 + 0.644 0.272 -1.966
ENSG00000110274 E050 55.7268493 0.0004947151 3.911956e-01 5.351310e-01 11 117395123 117395191 69 + 1.665 1.716 0.175
ENSG00000110274 E051 88.0240037 0.0081187048 5.069962e-01 6.426051e-01 11 117395547 117395722 176 + 1.866 1.911 0.152
ENSG00000110274 E052 27.7296796 0.0020609525 4.058344e-01 5.494862e-01 11 117396054 117396056 3 + 1.450 1.397 -0.184
ENSG00000110274 E053 92.8977139 0.0005734401 5.804827e-01 7.052252e-01 11 117396057 117396180 124 + 1.902 1.931 0.099
ENSG00000110274 E054 76.4368706 0.0003754104 3.049514e-01 4.469762e-01 11 117396550 117396611 62 + 1.866 1.828 -0.128
ENSG00000110274 E055 133.6637160 0.0002564129 9.707818e-01 9.857560e-01 11 117397091 117397313 223 + 2.072 2.078 0.019
ENSG00000110274 E056 86.0318096 0.0005316533 4.091814e-01 5.527932e-01 11 117407925 117408032 108 + 1.857 1.899 0.142
ENSG00000110274 E057 9.1024303 0.0023265681 6.922666e-02 1.420902e-01 11 117408526 117408755 230 + 1.085 0.890 -0.725
ENSG00000110274 E058 95.2282424 0.0002947131 2.590947e-03 9.038044e-03 11 117408890 117409004 115 + 1.833 1.964 0.442
ENSG00000110274 E059 30.8877937 0.0024233732 9.685503e-01 9.843349e-01 11 117409005 117409016 12 + 1.450 1.460 0.035
ENSG00000110274 E060 34.6897554 0.0006168260 9.400407e-01 9.663407e-01 11 117409017 117409028 12 + 1.493 1.505 0.039
ENSG00000110274 E061 19.7617405 0.0009398670 1.820197e-09 2.568764e-08 11 117409029 117409617 589 + 1.544 1.091 -1.585
ENSG00000110274 E062 112.9416533 0.0003411483 1.085935e-03 4.255750e-03 11 117409618 117409811 194 + 1.904 2.036 0.443
ENSG00000110274 E063 91.3800718 0.0074309264 3.243025e-04 1.478073e-03 11 117409812 117409965 154 + 1.740 1.965 0.760
ENSG00000110274 E064 6.3942406 0.0044009394 4.255562e-01 5.684999e-01 11 117409966 117410701 736 + 0.892 0.795 -0.379
ENSG00000110274 E065 69.8459748 0.0043436174 5.317104e-04 2.278156e-03 11 117410828 117410894 67 + 1.636 1.848 0.716
ENSG00000110274 E066 19.1501112 0.0037787143 7.940188e-01 8.683762e-01 11 117411112 117411427 316 + 1.267 1.250 -0.058
ENSG00000110274 E067 31.9962209 0.0006634561 9.902690e-02 1.889812e-01 11 117411428 117411794 367 + 1.538 1.437 -0.346
ENSG00000110274 E068 113.1935724 0.0003523521 1.495799e-04 7.451734e-04 11 117411795 117411917 123 + 1.891 2.044 0.514
ENSG00000110274 E069 468.9001205 0.0014284209 1.439580e-14 4.637376e-13 11 117412072 117413266 1195 + 2.470 2.665 0.651