ENSG00000110237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263674 ENSG00000110237 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF17 protein_coding protein_coding 3.750677 4.660789 2.643285 0.8212172 0.188875 -0.8158867 1.32294740 1.2598593 1.2822087 0.17662285 0.05340796 0.02517052 0.37353750 0.27756667 0.4887667 0.21120000 0.0198364715 0.0001115992 FALSE TRUE
ENST00000536481 ENSG00000110237 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF17 protein_coding retained_intron 3.750677 4.660789 2.643285 0.8212172 0.188875 -0.8158867 0.55056449 0.5864657 0.4256714 0.27511226 0.04068608 -0.45319877 0.14749167 0.11276667 0.1605000 0.04773333 0.6541488613 0.0001115992   FALSE
ENST00000537198 ENSG00000110237 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF17 protein_coding retained_intron 3.750677 4.660789 2.643285 0.8212172 0.188875 -0.8158867 0.37356192 0.3085864 0.3758022 0.08831773 0.01045046 0.27617685 0.10271667 0.06410000 0.1436667 0.07956667 0.0605581859 0.0001115992   FALSE
ENST00000543530 ENSG00000110237 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF17 protein_coding retained_intron 3.750677 4.660789 2.643285 0.8212172 0.188875 -0.8158867 0.78987925 1.2728463 0.4193888 0.18483743 0.05244355 -1.57899189 0.19787083 0.28663333 0.1575333 -0.12910000 0.2104724408 0.0001115992 FALSE TRUE
ENST00000544519 ENSG00000110237 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF17 protein_coding protein_coding 3.750677 4.660789 2.643285 0.8212172 0.188875 -0.8158867 0.56380316 0.7819584 0.1402138 0.15986507 0.08336890 -2.39840765 0.14337500 0.16596667 0.0495000 -0.11646667 0.0912861756 0.0001115992 FALSE FALSE
ENST00000643371 ENSG00000110237 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF17 protein_coding protein_coding 3.750677 4.660789 2.643285 0.8212172 0.188875 -0.8158867 0.08530826 0.3905819 0.0000000 0.11823980 0.00000000 -5.32402527 0.01862917 0.08326667 0.0000000 -0.08326667 0.0001115992 0.0001115992 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110237 E001 107.854558 0.0048920048 2.603914e-05 0.0001572251 11 73308276 73311564 3289 + 2.115 1.947 -0.565
ENSG00000110237 E002 25.405662 0.0030493561 2.937122e-03 0.0100785905 11 73311565 73311830 266 + 1.513 1.305 -0.718
ENSG00000110237 E003 0.000000       11 73342924 73342995 72 +      
ENSG00000110237 E004 0.000000       11 73342996 73343277 282 +      
ENSG00000110237 E005 12.227501 0.0016927240 1.071522e-01 0.2013375525 11 73346883 73346960 78 + 1.181 1.029 -0.547
ENSG00000110237 E006 5.526058 0.0030389172 5.573240e-03 0.0174844505 11 73346961 73347195 235 + 0.481 0.893 1.750
ENSG00000110237 E007 14.402498 0.0022109276 1.516030e-02 0.0408503165 11 73352830 73353012 183 + 1.284 1.070 -0.761
ENSG00000110237 E008 1.506124 0.0122209690 4.044261e-01 0.5481318391 11 73353013 73353262 250 + 0.257 0.411 0.960
ENSG00000110237 E009 12.502253 0.0014965862 8.077285e-01 0.8778360457 11 73355533 73355649 117 + 1.119 1.098 -0.076
ENSG00000110237 E010 12.324941 0.0324568292 9.693607e-01 0.9848524302 11 73355861 73355953 93 + 1.092 1.102 0.038
ENSG00000110237 E011 18.547507 0.0015437181 8.561639e-01 0.9110670512 11 73356175 73356351 177 + 1.274 1.262 -0.043
ENSG00000110237 E012 2.833679 0.0067032554 7.115354e-01 0.8084822158 11 73356477 73356708 232 + 0.584 0.526 -0.263
ENSG00000110237 E013 11.474494 0.0015574132 7.348365e-01 0.8256954521 11 73356709 73356759 51 + 1.091 1.060 -0.114
ENSG00000110237 E014 15.765950 0.0011442804 9.014616e-01 0.9412070965 11 73357025 73357134 110 + 1.203 1.195 -0.030
ENSG00000110237 E015 13.607743 0.0093708803 7.476784e-01 0.8351144703 11 73357242 73357327 86 + 1.157 1.126 -0.111
ENSG00000110237 E016 17.509737 0.0123351833 8.330650e-01 0.8953963296 11 73359834 73359952 119 + 1.225 1.246 0.076
ENSG00000110237 E017 23.576673 0.0009893180 4.372743e-01 0.5792511171 11 73360320 73360533 214 + 1.327 1.386 0.204
ENSG00000110237 E018 10.960333 0.0017030132 4.907595e-01 0.6281020651 11 73361088 73361161 74 + 0.996 1.070 0.271
ENSG00000110237 E019 13.038526 0.0107841297 4.577507e-01 0.5980613120 11 73362040 73362239 200 + 1.061 1.144 0.297
ENSG00000110237 E020 16.142074 0.0014000279 8.051156e-03 0.0239088866 11 73362433 73362734 302 + 1.335 1.116 -0.776
ENSG00000110237 E021 20.752186 0.0009843549 6.021551e-01 0.7231701635 11 73363206 73363455 250 + 1.335 1.298 -0.131
ENSG00000110237 E022 14.539409 0.0103117182 3.198633e-01 0.4629376331 11 73363747 73363833 87 + 1.105 1.208 0.369
ENSG00000110237 E023 12.067235 0.0030654130 5.807840e-02 0.1233412431 11 73364172 73364213 42 + 0.959 1.157 0.722
ENSG00000110237 E024 11.310313 0.0016253343 2.843263e-02 0.0688798809 11 73364214 73364239 26 + 0.897 1.133 0.869
ENSG00000110237 E025 18.906467 0.0011492739 1.868802e-01 0.3098157461 11 73364452 73364600 149 + 1.192 1.304 0.393
ENSG00000110237 E026 9.387586 0.0030556782 4.428108e-01 0.5843684824 11 73364601 73365122 522 + 0.918 1.008 0.334
ENSG00000110237 E027 5.054089 0.0048691488 6.489048e-01 0.7602915579 11 73365225 73365389 165 + 0.797 0.737 -0.241
ENSG00000110237 E028 20.967002 0.0010663302 1.309053e-01 0.2354154775 11 73365390 73365564 175 + 1.225 1.347 0.428
ENSG00000110237 E029 23.679551 0.0008157817 6.705963e-01 0.7770038832 11 73365678 73365947 270 + 1.343 1.376 0.114
ENSG00000110237 E030 124.298151 0.0071994926 2.666627e-04 0.0012438370 11 73367584 73369388 1805 + 1.952 2.128 0.587