ENSG00000110172

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320585 ENSG00000110172 HEK293_OSMI2_2hA HEK293_TMG_2hB CHORDC1 protein_coding protein_coding 40.64445 12.61031 66.35269 0.2053884 2.174323 2.394625 6.151755 2.6119910 10.308027 0.09651444 0.6677306 1.9764324 0.1677708 0.20696667 0.15510000 -0.05186667 4.311875e-02 2.504884e-19 FALSE TRUE
ENST00000457199 ENSG00000110172 HEK293_OSMI2_2hA HEK293_TMG_2hB CHORDC1 protein_coding protein_coding 40.64445 12.61031 66.35269 0.2053884 2.174323 2.394625 13.586304 5.7283001 21.380478 0.35054427 0.4526713 1.8982734 0.3630000 0.45360000 0.32280000 -0.13080000 1.127666e-03 2.504884e-19 FALSE TRUE
ENST00000525317 ENSG00000110172 HEK293_OSMI2_2hA HEK293_TMG_2hB CHORDC1 protein_coding nonsense_mediated_decay 40.64445 12.61031 66.35269 0.2053884 2.174323 2.394625 3.740726 0.3897171 6.376866 0.15044934 1.6527944 3.9980571 0.0657875 0.03063333 0.09536667 0.06473333 1.561465e-01 2.504884e-19 TRUE TRUE
MSTRG.6158.2 ENSG00000110172 HEK293_OSMI2_2hA HEK293_TMG_2hB CHORDC1 protein_coding   40.64445 12.61031 66.35269 0.2053884 2.174323 2.394625 2.811177 3.2535718 4.511472 0.18165648 0.3416261 0.4703408 0.1384208 0.25856667 0.06790000 -0.19066667 2.504884e-19 2.504884e-19 FALSE TRUE
MSTRG.6158.6 ENSG00000110172 HEK293_OSMI2_2hA HEK293_TMG_2hB CHORDC1 protein_coding   40.64445 12.61031 66.35269 0.2053884 2.174323 2.394625 12.589338 0.3796317 20.253124 0.19292769 1.7310010 5.7006016 0.2160375 0.03060000 0.30546667 0.27486667 1.228420e-02 2.504884e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110172 E001 135.562103 0.0002246461 2.286832e-03 8.110404e-03 11 90200429 90201443 1015 - 2.027 2.131 0.346
ENSG00000110172 E002 10.040878 0.0016924449 1.187450e-02 3.323034e-02 11 90201444 90201448 5 - 0.886 1.165 1.025
ENSG00000110172 E003 292.064025 0.0001910458 9.187895e-33 1.887873e-30 11 90201449 90201899 451 - 2.310 2.578 0.893
ENSG00000110172 E004 173.114114 0.0002105778 3.077131e-05 1.825952e-04 11 90201900 90201948 49 - 2.125 2.250 0.419
ENSG00000110172 E005 544.805296 0.0002590232 5.633403e-12 1.221228e-10 11 90201949 90202406 458 - 2.624 2.742 0.394
ENSG00000110172 E006 323.539823 0.0002103478 7.352209e-03 2.213374e-02 11 90202407 90202551 145 - 2.413 2.471 0.192
ENSG00000110172 E007 128.545333 0.0013970615 7.660935e-01 8.486806e-01 11 90202813 90202814 2 - 2.027 2.033 0.021
ENSG00000110172 E008 241.967543 0.0003769126 7.204715e-01 8.150819e-01 11 90202815 90202875 61 - 2.300 2.305 0.015
ENSG00000110172 E009 323.401077 0.0016916881 5.772991e-01 7.025694e-01 11 90203308 90203427 120 - 2.432 2.411 -0.069
ENSG00000110172 E010 307.467112 0.0001638620 1.201295e-01 2.201772e-01 11 90205460 90205565 106 - 2.415 2.370 -0.151
ENSG00000110172 E011 14.274075 0.0219950715 5.856024e-01 7.092710e-01 11 90205566 90206201 636 - 1.124 1.047 -0.278
ENSG00000110172 E012 230.403216 0.0003890672 4.565326e-02 1.013968e-01 11 90206202 90206272 71 - 2.295 2.228 -0.223
ENSG00000110172 E013 14.814546 0.0432982908 5.062296e-01 6.418869e-01 11 90206273 90206747 475 - 1.140 1.025 -0.416
ENSG00000110172 E014 8.756290 0.0018614430 8.687429e-01 9.196355e-01 11 90206748 90206810 63 - 0.920 0.892 -0.104
ENSG00000110172 E015 54.129286 0.0021572595 2.149784e-06 1.660362e-05 11 90206811 90209478 2668 - 1.712 1.358 -1.214
ENSG00000110172 E016 188.474724 0.0003366518 1.481579e-02 4.007719e-02 11 90210536 90210570 35 - 2.212 2.124 -0.295
ENSG00000110172 E017 173.964574 0.0016959962 1.380457e-02 3.778343e-02 11 90210571 90210591 21 - 2.180 2.075 -0.352
ENSG00000110172 E018 138.499659 0.0012787283 1.955536e-03 7.088307e-03 11 90210592 90210594 3 - 2.088 1.948 -0.468
ENSG00000110172 E019 3.404248 0.0044683040 4.344966e-03 1.410913e-02 11 90210595 90211214 620 - 0.661 0.000 -13.923
ENSG00000110172 E020 265.127029 0.0028531724 1.242525e-02 3.455761e-02 11 90211215 90211318 104 - 2.362 2.260 -0.339
ENSG00000110172 E021 3.187997 0.0047853222 6.172467e-01 7.351061e-01 11 90211319 90211335 17 - 0.580 0.483 -0.456
ENSG00000110172 E022 28.063491 0.0007983992 2.181477e-03 7.784410e-03 11 90211336 90213308 1973 - 1.431 1.144 -1.007
ENSG00000110172 E023 5.198797 0.1047071545 2.378833e-03 8.395201e-03 11 90213309 90213420 112 - 0.810 0.000 -14.190
ENSG00000110172 E024 12.029994 0.0150881580 2.892754e-05 1.727854e-04 11 90213421 90213978 558 - 1.124 0.373 -3.176
ENSG00000110172 E025 3.898560 0.0374402156 1.512529e-01 2.633774e-01 11 90213979 90214017 39 - 0.676 0.373 -1.460
ENSG00000110172 E026 298.614216 0.0005450954 6.063486e-04 2.556323e-03 11 90214018 90214175 158 - 2.413 2.311 -0.342
ENSG00000110172 E027 150.106488 0.0008914022 9.439337e-04 3.767839e-03 11 90215174 90215230 57 - 2.123 1.984 -0.468
ENSG00000110172 E028 1.182486 0.0113636586 1.473373e-01 2.580772e-01 11 90216464 90216553 90 - 0.351 0.000 -12.465
ENSG00000110172 E029 0.894217 0.0140054943 2.532169e-01 3.897181e-01 11 90217747 90218134 388 - 0.286 0.000 -12.059
ENSG00000110172 E030 185.858859 0.0006631721 3.062897e-04 1.404946e-03 11 90218135 90218184 50 - 2.214 2.080 -0.450
ENSG00000110172 E031 2.525837 0.0064063934 1.338053e-01 2.394443e-01 11 90222529 90222890 362 - 0.543 0.225 -1.872
ENSG00000110172 E032 203.966749 0.0023119893 6.197180e-05 3.411610e-04 11 90222891 90223145 255 - 2.258 2.092 -0.556