ENSG00000110090

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265641 ENSG00000110090 HEK293_OSMI2_2hA HEK293_TMG_2hB CPT1A protein_coding protein_coding 3.782104 3.525586 5.112548 0.45932 0.2486583 0.5349122 3.1186754 3.165538 3.873275 0.2919641 0.1073037 0.290273 0.84721250 0.9096667 0.7621333 -0.1475333 3.346530e-01 9.100559e-07 FALSE TRUE
ENST00000539743 ENSG00000110090 HEK293_OSMI2_2hA HEK293_TMG_2hB CPT1A protein_coding protein_coding 3.782104 3.525586 5.112548 0.45932 0.2486583 0.5349122 0.4062617 0.000000 1.032169 0.0000000 0.3650084 6.703445 0.08221667 0.0000000 0.1961667 0.1961667 9.100559e-07 9.100559e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110090 E001 0.0000000       11 68754620 68754621 2 -      
ENSG00000110090 E002 1.5435132 0.2221710967 0.1256548980 0.228082241 11 68754622 68754851 230 - 0.197 0.581 2.291
ENSG00000110090 E003 264.2030875 0.0079432092 0.0056394778 0.017656582 11 68754883 68757612 2730 - 2.357 2.489 0.440
ENSG00000110090 E004 37.6489807 0.0006091138 0.2582317437 0.395447690 11 68757613 68757730 118 - 1.610 1.577 -0.112
ENSG00000110090 E005 33.3467594 0.0006765700 0.3418802366 0.485831835 11 68759569 68759661 93 - 1.554 1.528 -0.091
ENSG00000110090 E006 35.1518369 0.0103239297 0.4428947072 0.584448799 11 68760225 68760338 114 - 1.575 1.545 -0.102
ENSG00000110090 E007 39.2165358 0.0007252594 0.4960761484 0.632807485 11 68761535 68761687 153 - 1.607 1.598 -0.030
ENSG00000110090 E008 32.2675900 0.0006692487 0.3451441429 0.489225999 11 68762627 68762761 135 - 1.537 1.509 -0.095
ENSG00000110090 E009 38.1466222 0.0021209714 0.6595396337 0.768344357 11 68773265 68773429 165 - 1.594 1.598 0.011
ENSG00000110090 E010 0.1451727 0.0439500101 0.5840452714   11 68773603 68773887 285 - 0.110 0.000 -9.375
ENSG00000110090 E011 33.7486752 0.0006813527 0.4669733284 0.606497077 11 68775316 68775432 117 - 1.551 1.537 -0.046
ENSG00000110090 E012 31.3618165 0.0050050848 0.2540969818 0.390732968 11 68780640 68780745 106 - 1.537 1.487 -0.169
ENSG00000110090 E013 36.3729033 0.0006092857 0.0036342106 0.012109582 11 68781771 68781959 189 - 1.640 1.503 -0.465
ENSG00000110090 E014 36.8392746 0.0006330584 0.0111261632 0.031467958 11 68784815 68785010 196 - 1.637 1.523 -0.388
ENSG00000110090 E015 0.9921708 0.0416874824 0.3213018754 0.464537395 11 68785744 68786035 292 - 0.198 0.393 1.352
ENSG00000110090 E016 24.7150140 0.0009596335 0.0512221963 0.111329120 11 68793315 68793402 88 - 1.461 1.356 -0.364
ENSG00000110090 E017 29.6428752 0.0174583023 0.0834199238 0.164919736 11 68794804 68794911 108 - 1.547 1.414 -0.454
ENSG00000110090 E018 25.3562409 0.0007758431 0.6242537222 0.740643521 11 68796856 68796933 78 - 1.425 1.421 -0.014
ENSG00000110090 E019 29.7323853 0.0008687725 0.1153847329 0.213409542 11 68799218 68799355 138 - 1.525 1.456 -0.239
ENSG00000110090 E020 23.0777652 0.0008363581 0.0006279812 0.002635618 11 68804000 68804101 102 - 1.478 1.262 -0.751
ENSG00000110090 E021 24.3410307 0.0188436550 0.0594668493 0.125716088 11 68807467 68807515 49 - 1.295 1.494 0.688
ENSG00000110090 E022 27.1757437 0.0091817107 0.0553823552 0.118645073 11 68807516 68807566 51 - 1.354 1.529 0.603
ENSG00000110090 E023 29.4902114 0.0038487394 0.2285514718 0.360696684 11 68807567 68807638 72 - 1.425 1.533 0.371
ENSG00000110090 E024 17.1048253 0.0024539510 0.4312304510 0.573797588 11 68812437 68812437 1 - 1.211 1.304 0.326
ENSG00000110090 E025 40.3670511 0.0021279118 0.9329415482 0.961735696 11 68812438 68812576 139 - 1.601 1.633 0.110
ENSG00000110090 E026 31.1955613 0.0095217216 0.4662046946 0.605768730 11 68815334 68815487 154 - 1.466 1.544 0.268
ENSG00000110090 E027 0.1817044 0.0401236783 0.4088941491   11 68815488 68815503 16 - 0.000 0.136 9.080
ENSG00000110090 E028 0.0000000       11 68818599 68818692 94 -      
ENSG00000110090 E029 0.6266857 0.0172671820 0.8646188759 0.916740089 11 68839552 68839684 133 - 0.198 0.239 0.352
ENSG00000110090 E030 11.8219124 0.1013355224 0.9602615919 0.978983758 11 68841775 68841931 157 - 1.086 1.120 0.121
ENSG00000110090 E031 0.0000000       11 68844145 68844410 266 -