ENSG00000110075

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265636 ENSG00000110075 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R3 protein_coding protein_coding 29.88731 11.05816 48.07785 0.3213094 0.2046706 2.119257 0.4782698 0.7173841 0.0000000 0.08702773 0.0000000 -6.1846454 0.04258750 0.064966667 0.00000000 -0.06496667 3.608430e-23 3.60843e-23 FALSE TRUE
ENST00000265637 ENSG00000110075 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R3 protein_coding protein_coding 29.88731 11.05816 48.07785 0.3213094 0.2046706 2.119257 1.1212975 0.9544572 1.1598928 0.95445724 0.1933778 0.2785871 0.06571667 0.085833333 0.02413333 -0.06170000 6.330325e-01 3.60843e-23 FALSE TRUE
ENST00000393800 ENSG00000110075 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R3 protein_coding protein_coding 29.88731 11.05816 48.07785 0.3213094 0.2046706 2.119257 14.2579277 4.8165295 22.4841626 0.26258415 0.6314368 2.2204925 0.47121667 0.437566667 0.46760000 0.03003333 7.934750e-01 3.60843e-23 FALSE TRUE
ENST00000527403 ENSG00000110075 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R3 protein_coding protein_coding 29.88731 11.05816 48.07785 0.3213094 0.2046706 2.119257 0.9642154 2.1983181 0.8831092 0.64167361 0.4551050 -1.3060395 0.04590000 0.196266667 0.01830000 -0.17796667 5.695714e-04 3.60843e-23 FALSE TRUE
ENST00000529710 ENSG00000110075 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R3 protein_coding protein_coding 29.88731 11.05816 48.07785 0.3213094 0.2046706 2.119257 2.0121018 0.1007999 3.7843943 0.06264905 0.3956495 5.0978408 0.04520833 0.009233333 0.07876667 0.06953333 2.399509e-05 3.60843e-23 FALSE TRUE
ENST00000529907 ENSG00000110075 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R3 protein_coding protein_coding 29.88731 11.05816 48.07785 0.3213094 0.2046706 2.119257 3.1539187 0.5966197 6.0137844 0.29835435 0.5597168 3.3118059 0.08412917 0.054266667 0.12516667 0.07090000 5.307707e-01 3.60843e-23 FALSE FALSE
ENST00000530734 ENSG00000110075 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R3 protein_coding protein_coding 29.88731 11.05816 48.07785 0.3213094 0.2046706 2.119257 0.7408182 0.8244563 0.9789942 0.34972555 0.1637363 0.2451257 0.03876250 0.073633333 0.02033333 -0.05330000 1.279887e-01 3.60843e-23   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110075 E001 1.0425102 0.0120582826 7.540186e-01 8.397552e-01 11 68460533 68460730 198 + 0.261 0.248 -0.095
ENSG00000110075 E002 1.4864473 0.0088328886 4.408422e-01 5.824860e-01 11 68460731 68460737 7 + 0.349 0.248 -0.680
ENSG00000110075 E003 4.8049571 0.0033840006 3.961459e-02 9.031778e-02 11 68460738 68460746 9 + 0.709 0.405 -1.416
ENSG00000110075 E004 4.8049571 0.0033840006 3.961459e-02 9.031778e-02 11 68460747 68460747 1 + 0.709 0.405 -1.416
ENSG00000110075 E005 5.3918769 0.0029559194 1.994823e-02 5.137771e-02 11 68460748 68460748 1 + 0.753 0.405 -1.597
ENSG00000110075 E006 6.1606148 0.0027574827 3.573664e-02 8.307537e-02 11 68460749 68460751 3 + 0.793 0.520 -1.172
ENSG00000110075 E007 6.1606148 0.0027574827 3.573664e-02 8.307537e-02 11 68460752 68460752 1 + 0.793 0.520 -1.172
ENSG00000110075 E008 6.3078638 0.0026522566 3.055452e-02 7.305620e-02 11 68460753 68460754 2 + 0.803 0.520 -1.209
ENSG00000110075 E009 25.1567179 0.0007620670 5.251656e-05 2.943348e-04 11 68460755 68460769 15 + 1.345 1.043 -1.075
ENSG00000110075 E010 65.5787058 0.0003478213 9.653219e-06 6.441211e-05 11 68460770 68460812 43 + 1.731 1.580 -0.513
ENSG00000110075 E011 69.9566761 0.0003383782 4.699549e-06 3.365778e-05 11 68460813 68460827 15 + 1.758 1.606 -0.516
ENSG00000110075 E012 50.7882286 0.0004558376 5.584584e-03 1.751192e-02 11 68505145 68505249 105 + 1.609 1.543 -0.225
ENSG00000110075 E013 24.3494255 0.0024016819 1.590886e-01 2.738950e-01 11 68505250 68505271 22 + 1.291 1.273 -0.061
ENSG00000110075 E014 3.6086528 0.0043600852 4.000445e-01 5.437727e-01 11 68515028 68515166 139 + 0.589 0.520 -0.317
ENSG00000110075 E015 53.6038110 0.0004738128 1.309303e-04 6.628637e-04 11 68519501 68519505 5 + 1.642 1.503 -0.472
ENSG00000110075 E016 76.5446761 0.0003376981 2.475550e-05 1.503448e-04 11 68519506 68519562 57 + 1.791 1.675 -0.393
ENSG00000110075 E017 84.4883756 0.0003479707 2.507130e-06 1.909267e-05 11 68519563 68519634 72 + 1.836 1.702 -0.451
ENSG00000110075 E018 47.0103612 0.0006279125 3.929933e-05 2.269514e-04 11 68519635 68519651 17 + 1.593 1.410 -0.628
ENSG00000110075 E019 2.3595598 0.0061706506 1.460621e-01 2.563339e-01 11 68522494 68522689 196 + 0.486 0.248 -1.416
ENSG00000110075 E020 0.0000000       11 68535411 68535532 122 +      
ENSG00000110075 E021 115.6310741 0.0002417978 1.933350e-10 3.247051e-09 11 68537659 68537815 157 + 1.977 1.797 -0.603
ENSG00000110075 E022 96.9805735 0.0002998630 3.309002e-06 2.454793e-05 11 68537816 68537891 76 + 1.892 1.781 -0.374
ENSG00000110075 E023 166.2510952 0.0007514117 2.529305e-11 4.931754e-10 11 68544838 68545024 187 + 2.129 1.978 -0.506
ENSG00000110075 E024 160.1243116 0.0002437103 5.689276e-12 1.232353e-10 11 68548067 68548204 138 + 2.113 1.960 -0.512
ENSG00000110075 E025 0.7469680 0.0174431420 3.261768e-01 4.696175e-01 11 68550990 68551120 131 + 0.227 0.000 -10.543
ENSG00000110075 E026 117.5864090 0.0042009099 8.221371e-08 8.490128e-07 11 68551121 68551186 66 + 1.986 1.798 -0.635
ENSG00000110075 E027 0.4460135 0.0331015592 6.646541e-01 7.724384e-01 11 68551187 68551220 34 + 0.150 0.000 -9.850
ENSG00000110075 E028 145.7699850 0.0058999055 3.667917e-07 3.333378e-06 11 68554145 68554257 113 + 2.076 1.902 -0.583
ENSG00000110075 E029 8.7223983 0.0515014325 8.831162e-01 9.292018e-01 11 68558196 68558565 370 + 0.855 0.981 0.476
ENSG00000110075 E030 131.0935623 0.0089735727 7.796766e-06 5.309777e-05 11 68558566 68558641 76 + 2.031 1.854 -0.593
ENSG00000110075 E031 103.9159452 0.0114384933 5.718117e-05 3.174912e-04 11 68558642 68558679 38 + 1.930 1.750 -0.607
ENSG00000110075 E032 164.7923769 0.0014925508 4.909164e-08 5.301712e-07 11 68564303 68564423 121 + 2.119 2.006 -0.378
ENSG00000110075 E033 83.0931014 0.0007484645 2.775213e-05 1.663679e-04 11 68564424 68564432 9 + 1.825 1.716 -0.371
ENSG00000110075 E034 0.3697384 0.0274424043 1.782392e-02 4.676077e-02 11 68566999 68567013 15 + 0.000 0.405 13.520
ENSG00000110075 E035 166.0606683 0.0002481836 5.879583e-06 4.120711e-05 11 68567014 68567166 153 + 2.113 2.064 -0.161
ENSG00000110075 E036 151.8842373 0.0036756249 1.910175e-03 6.947547e-03 11 68569748 68569897 150 + 2.072 2.039 -0.111
ENSG00000110075 E037 102.3866556 0.0032819293 9.829976e-03 2.834575e-02 11 68571040 68571098 59 + 1.900 1.877 -0.077
ENSG00000110075 E038 66.5452674 0.0004669668 4.846170e-02 1.064405e-01 11 68571099 68571104 6 + 1.710 1.716 0.020
ENSG00000110075 E039 0.1482932 0.0412623010 9.811016e-02   11 68571105 68571216 112 + 0.000 0.248 12.437
ENSG00000110075 E040 138.7710141 0.0002431783 2.387095e-03 8.420592e-03 11 68574109 68574224 116 + 2.029 2.028 -0.002
ENSG00000110075 E041 123.6778989 0.0018911746 3.943837e-03 1.298462e-02 11 68575958 68576043 86 + 1.982 1.967 -0.050
ENSG00000110075 E042 98.2458155 0.0002791144 8.367447e-03 2.470679e-02 11 68583043 68583129 87 + 1.884 1.880 -0.013
ENSG00000110075 E043 10.9341279 0.1709103734 9.786702e-01 9.907651e-01 11 68586276 68587797 1522 + 0.944 1.077 0.491
ENSG00000110075 E044 5.6274922 0.0357680237 2.566935e-02 6.325665e-02 11 68587798 68587926 129 + 0.773 0.405 -1.679
ENSG00000110075 E045 69.1953821 0.0042833772 2.886930e-02 6.973979e-02 11 68587927 68587944 18 + 1.736 1.715 -0.072
ENSG00000110075 E046 95.9965049 0.0014011230 2.527476e-02 6.243939e-02 11 68587945 68587977 33 + 1.869 1.876 0.023
ENSG00000110075 E047 105.8668089 0.0003301557 1.387013e-02 3.793187e-02 11 68587978 68588024 47 + 1.910 1.918 0.027
ENSG00000110075 E048 127.9821957 0.0003123556 7.396111e-04 3.041462e-03 11 68590660 68590714 55 + 1.996 1.975 -0.072
ENSG00000110075 E049 212.9249728 0.0002271565 8.544000e-06 5.767040e-05 11 68591576 68591706 131 + 2.218 2.193 -0.081
ENSG00000110075 E050 221.6471900 0.0001752333 2.351984e-05 1.434936e-04 11 68596097 68596218 122 + 2.233 2.220 -0.043
ENSG00000110075 E051 217.2429186 0.0002043006 1.078097e-01 2.022982e-01 11 68600341 68600494 154 + 2.209 2.279 0.233
ENSG00000110075 E052 102.1819352 0.0029908660 4.865470e-01 6.242584e-01 11 68601863 68601885 23 + 1.880 1.961 0.273
ENSG00000110075 E053 154.6775595 0.0020552207 8.659574e-02 1.699574e-01 11 68601886 68601969 84 + 2.065 2.110 0.149
ENSG00000110075 E054 188.5091611 0.0002521360 2.097914e-02 5.354504e-02 11 68603342 68603492 151 + 2.152 2.193 0.140
ENSG00000110075 E055 1.1760401 0.0133390918 1.510652e-01 2.631135e-01 11 68609473 68609610 138 + 0.190 0.521 2.078
ENSG00000110075 E056 0.5503986 0.0220839061 7.141366e-02 1.456787e-01 11 68609611 68609628 18 + 0.056 0.406 3.494
ENSG00000110075 E057 3.0365053 0.0865837534 2.537407e-01 3.903317e-01 11 68609775 68609903 129 + 0.445 0.752 1.379
ENSG00000110075 E058 115.2504461 0.0004509882 2.673185e-02 6.543406e-02 11 68609904 68609950 47 + 1.945 1.968 0.077
ENSG00000110075 E059 127.3011733 0.0003346464 1.073496e-01 2.016293e-01 11 68609951 68610023 73 + 1.981 2.034 0.180
ENSG00000110075 E060 10.0314912 0.0029835820 3.460109e-01 4.901538e-01 11 68613036 68613065 30 + 0.880 1.100 0.815
ENSG00000110075 E061 839.6762246 0.0020711301 2.472538e-34 5.804398e-32 11 68613066 68614631 1566 + 2.707 3.102 1.315
ENSG00000110075 E062 525.6443651 0.0285601711 1.880501e-12 4.406361e-11 11 68614632 68615334 703 + 2.382 3.062 2.263