ENSG00000110074

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263578 ENSG00000110074 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXRED1 protein_coding protein_coding 50.87119 82.85458 32.96593 3.048303 0.09755645 -1.329342 32.538186 62.688158 19.760301 2.8825532 0.76278331 -1.6650882 0.60540833 0.75626667 0.59940000 -0.15686667 3.079415e-04 2.433704e-12 FALSE TRUE
ENST00000685484 ENSG00000110074 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXRED1 protein_coding protein_coding 50.87119 82.85458 32.96593 3.048303 0.09755645 -1.329342 2.802416 3.167495 2.329428 0.3040151 0.09734334 -0.4417336 0.05929583 0.03813333 0.07070000 0.03256667 5.378641e-04 2.433704e-12 FALSE TRUE
ENST00000687786 ENSG00000110074 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXRED1 protein_coding retained_intron 50.87119 82.85458 32.96593 3.048303 0.09755645 -1.329342 2.531632 1.358917 2.240421 0.2410801 0.06458410 0.7171602 0.06040833 0.01623333 0.06796667 0.05173333 8.908531e-12 2.433704e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110074 E001 0.7363589 0.0154769025 5.992498e-04 2.530506e-03 11 126269024 126269028 5 + 0.565 0.000 -12.492
ENSG00000110074 E002 1.3285892 0.0097962324 1.069750e-04 5.541941e-04 11 126269029 126269054 26 + 0.722 0.078 -4.432
ENSG00000110074 E003 7.9576375 0.0022034042 4.674135e-02 1.033642e-01 11 126269055 126269134 80 + 1.047 0.816 -0.871
ENSG00000110074 E004 9.5293360 0.0024714819 3.434743e-01 4.875128e-01 11 126269135 126269147 13 + 1.026 0.921 -0.390
ENSG00000110074 E005 11.3727581 0.0019606244 3.775670e-01 5.218984e-01 11 126269148 126269153 6 + 1.087 0.997 -0.330
ENSG00000110074 E006 11.4416688 0.0025470346 7.291083e-01 8.213836e-01 11 126269154 126269156 3 + 1.047 1.014 -0.123
ENSG00000110074 E007 13.8094391 0.0012940712 8.925922e-01 9.353878e-01 11 126269157 126269162 6 + 1.106 1.097 -0.032
ENSG00000110074 E008 21.4422545 0.0066001547 2.872580e-01 4.277462e-01 11 126269163 126269170 8 + 1.350 1.261 -0.311
ENSG00000110074 E009 52.9515926 0.0005456565 2.590204e-01 3.963830e-01 11 126269171 126269189 19 + 1.705 1.649 -0.189
ENSG00000110074 E010 63.1785711 0.0004044993 5.053767e-01 6.411682e-01 11 126269190 126269190 1 + 1.757 1.729 -0.095
ENSG00000110074 E011 69.3853650 0.0003768459 7.294125e-01 8.215958e-01 11 126269191 126269191 1 + 1.784 1.773 -0.039
ENSG00000110074 E012 74.6730446 0.0004697198 4.281502e-01 5.709504e-01 11 126269192 126269193 2 + 1.831 1.800 -0.107
ENSG00000110074 E013 113.4955923 0.0045119696 7.400652e-01 8.295847e-01 11 126269194 126269206 13 + 1.971 1.993 0.074
ENSG00000110074 E014 185.9585541 0.0013136668 1.503367e-01 2.621290e-01 11 126269207 126269246 40 + 2.156 2.211 0.186
ENSG00000110074 E015 216.6891697 0.0003596650 1.402877e-01 2.484165e-01 11 126269247 126269291 45 + 2.226 2.274 0.161
ENSG00000110074 E016 14.3013425 0.0048690836 7.042337e-14 2.044047e-12 11 126269292 126269415 124 + 1.519 0.830 -2.478
ENSG00000110074 E017 65.1574266 0.0108680041 5.078446e-20 3.233937e-18 11 126270019 126270944 926 + 2.117 1.512 -2.043
ENSG00000110074 E018 32.1201506 0.0015512223 4.272234e-10 6.773470e-09 11 126270945 126271219 275 + 1.714 1.319 -1.356
ENSG00000110074 E019 22.9193991 0.0065185644 1.076736e-03 4.223716e-03 11 126271220 126271295 76 + 1.490 1.224 -0.927
ENSG00000110074 E020 20.1620846 0.0152157177 2.321229e-04 1.100503e-03 11 126271296 126271350 55 + 1.490 1.140 -1.226
ENSG00000110074 E021 18.7121741 0.0229694162 4.539548e-04 1.982306e-03 11 126271351 126271436 86 + 1.475 1.101 -1.312
ENSG00000110074 E022 556.9397125 0.0003132944 8.768108e-01 9.249323e-01 11 126271437 126271657 221 + 2.665 2.673 0.029
ENSG00000110074 E023 4.3535273 0.0036461816 4.832503e-07 4.285663e-06 11 126271658 126271718 61 + 1.068 0.378 -2.944
ENSG00000110074 E024 4.6093287 0.0034927556 4.867694e-07 4.314044e-06 11 126271719 126271855 137 + 1.087 0.413 -2.823
ENSG00000110074 E025 1.3620004 0.0096793192 1.076160e-04 5.571428e-04 11 126271856 126271881 26 + 0.722 0.079 -4.431
ENSG00000110074 E026 10.7803400 0.0016042476 3.541532e-09 4.740233e-08 11 126271998 126272477 480 + 1.360 0.775 -2.144
ENSG00000110074 E027 6.4109180 0.0025600597 1.425022e-03 5.389838e-03 11 126272478 126272682 205 + 1.068 0.678 -1.505
ENSG00000110074 E028 10.2576914 0.0139159380 6.870976e-07 5.910038e-06 11 126272683 126272968 286 + 1.339 0.788 -2.022
ENSG00000110074 E029 382.2815253 0.0001399141 1.636468e-01 2.798831e-01 11 126272969 126273033 65 + 2.527 2.504 -0.078
ENSG00000110074 E030 357.9235070 0.0001945734 1.416842e-01 2.503417e-01 11 126273034 126273079 46 + 2.500 2.474 -0.088
ENSG00000110074 E031 6.3373412 0.1125688409 3.866301e-02 8.855965e-02 11 126273080 126273083 4 + 1.089 0.659 -1.664
ENSG00000110074 E032 5.7054467 0.0694870455 1.267939e-03 4.870383e-03 11 126273084 126273088 5 + 1.107 0.557 -2.180
ENSG00000110074 E033 5.2678523 0.1276459524 2.250563e-02 5.673183e-02 11 126273089 126273090 2 + 1.050 0.558 -1.965
ENSG00000110074 E034 17.6183837 0.0079191470 3.310228e-08 3.696509e-07 11 126273091 126273315 225 + 1.520 1.030 -1.725
ENSG00000110074 E035 9.8206420 0.0086841901 1.668150e-02 4.423720e-02 11 126273316 126273335 20 + 1.157 0.889 -0.986
ENSG00000110074 E036 251.1816827 0.0016181192 2.132054e-01 3.423180e-01 11 126273336 126273338 3 + 2.351 2.319 -0.106
ENSG00000110074 E037 515.9778517 0.0001944880 7.482812e-01 8.355562e-01 11 126273339 126273454 116 + 2.638 2.638 -0.001
ENSG00000110074 E038 5.6571389 0.0028373779 1.168521e-11 2.405441e-10 11 126273455 126273913 459 + 1.231 0.378 -3.531
ENSG00000110074 E039 10.1847908 0.0016393174 3.389404e-11 6.467692e-10 11 126273914 126274926 1013 + 1.380 0.713 -2.465
ENSG00000110074 E040 205.8476248 0.0009471422 6.230075e-01 7.396837e-01 11 126274927 126274930 4 + 2.223 2.245 0.072
ENSG00000110074 E041 391.5672644 0.0007793428 6.329735e-02 1.322032e-01 11 126274931 126275021 91 + 2.479 2.530 0.171
ENSG00000110074 E042 20.4926562 0.0071698329 1.421509e-15 5.265949e-14 11 126275022 126275326 305 + 1.657 0.989 -2.343
ENSG00000110074 E043 280.1636062 0.0002147303 2.818399e-03 9.728646e-03 11 126275327 126275370 44 + 2.312 2.394 0.273
ENSG00000110074 E044 310.1822651 0.0001512691 6.921551e-02 1.420704e-01 11 126275371 126275428 58 + 2.382 2.430 0.162
ENSG00000110074 E045 15.3558011 0.0023291884 2.718512e-08 3.086133e-07 11 126275429 126275793 365 + 1.459 0.979 -1.706
ENSG00000110074 E046 373.8104408 0.0002092774 5.553033e-01 6.841911e-01 11 126275794 126275870 77 + 2.486 2.504 0.061
ENSG00000110074 E047 534.5266401 0.0006502946 4.005853e-02 9.113863e-02 11 126276059 126276219 161 + 2.618 2.668 0.164
ENSG00000110074 E048 5.2649255 0.0676382607 1.717922e-01 2.905435e-01 11 126276220 126276246 27 + 0.900 0.663 -0.944
ENSG00000110074 E049 248.0819020 0.0001907434 3.218774e-02 7.621386e-02 11 126276394 126276421 28 + 2.273 2.336 0.210
ENSG00000110074 E050 274.4394744 0.0007328432 1.825328e-02 4.768447e-02 11 126276422 126276452 31 + 2.309 2.381 0.242
ENSG00000110074 E051 400.5807269 0.0001877587 5.503588e-02 1.180577e-01 11 126276453 126276523 71 + 2.494 2.540 0.154
ENSG00000110074 E052 3.4762012 0.1853177911 1.711838e-02 4.520273e-02 11 126276912 126276997 86 + 0.930 0.411 -2.254
ENSG00000110074 E053 6.1538992 0.0028055515 1.293772e-04 6.561402e-04 11 126276998 126277070 73 + 1.106 0.640 -1.804
ENSG00000110074 E054 250.8351732 0.0008282717 3.251615e-01 4.685939e-01 11 126277071 126277073 3 + 2.300 2.335 0.116
ENSG00000110074 E055 484.8931337 0.0010936364 4.513353e-01 5.923061e-01 11 126277074 126277175 102 + 2.594 2.619 0.083
ENSG00000110074 E056 42.9146657 0.0006094179 2.448360e-05 1.488844e-04 11 126277176 126277434 259 + 1.736 1.501 -0.798
ENSG00000110074 E057 1265.4394924 0.0017837713 8.595072e-07 7.240798e-06 11 126277435 126278131 697 + 2.941 3.054 0.378