ENSG00000110066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304363 ENSG00000110066 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5B protein_coding protein_coding 8.716182 5.029625 12.26358 0.2242465 0.4938936 1.284168 1.5851571 0.7938116 2.7056763 0.06744955 0.1191171 1.756382 0.17295833 0.1596333 0.2212667 0.06163333 2.170138e-01 2.796972e-08 FALSE TRUE
ENST00000401547 ENSG00000110066 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5B protein_coding protein_coding 8.716182 5.029625 12.26358 0.2242465 0.4938936 1.284168 1.1301416 2.3274604 0.5875181 0.42303250 0.5875181 -1.967888 0.18757917 0.4581667 0.0511000 -0.40706667 3.542180e-02 2.796972e-08 FALSE TRUE
ENST00000405515 ENSG00000110066 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5B protein_coding protein_coding 8.716182 5.029625 12.26358 0.2242465 0.4938936 1.284168 3.3486746 1.4447300 4.9189547 0.24376577 0.9777616 1.760530 0.37257917 0.2901667 0.3968333 0.10666667 5.885673e-01 2.796972e-08 FALSE TRUE
ENST00000441488 ENSG00000110066 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5B protein_coding nonsense_mediated_decay 8.716182 5.029625 12.26358 0.2242465 0.4938936 1.284168 0.9343543 0.0000000 1.2895294 0.00000000 0.2483346 7.021845 0.08219167 0.0000000 0.1051000 0.10510000 2.796972e-08 2.796972e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110066 E001 56.953012 0.0004518892 1.531713e-01 2.659870e-01 11 68154863 68156039 1177 - 1.755 1.698 -0.192
ENSG00000110066 E002 33.333432 0.0005975881 1.069203e-02 3.043549e-02 11 68156040 68156926 887 - 1.557 1.401 -0.535
ENSG00000110066 E003 7.652053 0.0023504544 3.375668e-01 4.814506e-01 11 68156927 68156954 28 - 0.953 0.848 -0.400
ENSG00000110066 E004 53.842644 0.0004115127 7.629679e-03 2.284743e-02 11 68156955 68157579 625 - 1.752 1.627 -0.423
ENSG00000110066 E005 64.905324 0.0004103325 3.860976e-08 4.257569e-07 11 68157580 68158240 661 - 1.866 1.606 -0.882
ENSG00000110066 E006 18.035911 0.0009720260 5.618215e-03 1.759961e-02 11 68158241 68158292 52 - 1.321 1.083 -0.847
ENSG00000110066 E007 70.360777 0.0200912014 7.934856e-05 4.247986e-04 11 68158293 68159171 879 - 1.909 1.591 -1.076
ENSG00000110066 E008 1.174906 0.0108647759 2.493192e-03 8.744218e-03 11 68165715 68165718 4 - 0.083 0.605 3.847
ENSG00000110066 E009 5.727741 0.0215912043 7.954765e-04 3.243582e-03 11 68165719 68165776 58 - 0.596 1.078 1.900
ENSG00000110066 E010 50.859340 0.0097513244 3.303364e-09 4.447217e-08 11 68165777 68165948 172 - 1.509 1.925 1.410
ENSG00000110066 E011 116.257692 0.0059352680 1.698352e-18 9.094054e-17 11 68165949 68166406 458 - 1.855 2.283 1.435
ENSG00000110066 E012 104.914926 0.0002768757 1.171923e-17 5.697136e-16 11 68166407 68166981 575 - 1.875 2.180 1.023
ENSG00000110066 E013 80.927279 0.0003295509 6.696184e-02 1.383243e-01 11 68166982 68167178 197 - 1.857 1.946 0.297
ENSG00000110066 E014 57.718293 0.0022217188 8.926125e-01 9.353902e-01 11 68171015 68171118 104 - 1.742 1.748 0.022
ENSG00000110066 E015 40.894549 0.0041690239 7.159843e-01 8.117554e-01 11 68171119 68171151 33 - 1.600 1.590 -0.037
ENSG00000110066 E016 30.901064 0.0007391843 6.041331e-01 7.247681e-01 11 68171232 68171251 20 - 1.486 1.466 -0.069
ENSG00000110066 E017 1.184562 0.0106166884 3.326823e-02 7.832680e-02 11 68171252 68171296 45 - 0.428 0.000 -12.171
ENSG00000110066 E018 57.901641 0.0004624876 2.313736e-01 3.641192e-01 11 68171543 68171653 111 - 1.760 1.715 -0.150
ENSG00000110066 E019 37.460171 0.0006238487 4.253485e-03 1.385148e-02 11 68171654 68171676 23 - 1.610 1.443 -0.571
ENSG00000110066 E020 41.633425 0.0059771875 1.069026e-01 2.009683e-01 11 68171677 68171709 33 - 1.634 1.536 -0.335
ENSG00000110066 E021 55.687334 0.0009681523 2.538212e-03 8.877956e-03 11 68173804 68173882 79 - 1.772 1.627 -0.493
ENSG00000110066 E022 33.073168 0.0022339611 2.118697e-03 7.592131e-03 11 68173883 68173913 31 - 1.567 1.365 -0.696
ENSG00000110066 E023 0.147249 0.0444910801 1.000000e+00   11 68174088 68174210 123 - 0.083 0.000 -9.171
ENSG00000110066 E024 40.038767 0.0005720208 2.972686e-02 7.142251e-02 11 68175018 68175046 29 - 1.625 1.509 -0.397
ENSG00000110066 E025 74.664047 0.0003707447 3.063846e-02 7.321162e-02 11 68175047 68175183 137 - 1.880 1.799 -0.270
ENSG00000110066 E026 0.294498 0.4166562066 6.682663e-01   11 68176526 68176714 189 - 0.152 0.000 -10.171
ENSG00000110066 E027 1.210485 0.0111550376 2.449273e-01 3.799571e-01 11 68179470 68179537 68 - 0.393 0.177 -1.543
ENSG00000110066 E028 1.615814 0.0116663673 1.025985e-02 2.940540e-02 11 68179538 68179822 285 - 0.520 0.000 -12.629
ENSG00000110066 E029 37.086454 0.0006951073 4.154422e-01 5.588244e-01 11 68180132 68180154 23 - 1.565 1.529 -0.123
ENSG00000110066 E030 46.793961 0.0006394806 9.586744e-01 9.781131e-01 11 68180155 68180200 46 - 1.650 1.662 0.039
ENSG00000110066 E031 68.971181 0.0003878215 8.562969e-01 9.111495e-01 11 68185781 68185928 148 - 1.813 1.836 0.077
ENSG00000110066 E032 0.000000       11 68189606 68189916 311 -      
ENSG00000110066 E033 56.167811 0.0004166695 1.077662e-02 3.063072e-02 11 68189917 68190152 236 - 1.768 1.652 -0.392
ENSG00000110066 E034 0.000000       11 68212600 68212754 155 -      
ENSG00000110066 E035 6.624521 0.0025416893 3.807782e-02 8.749534e-02 11 68213138 68213415 278 - 0.933 0.656 -1.099
ENSG00000110066 E036 17.690122 0.0010047177 2.943260e-04 1.356770e-03 11 68213477 68213828 352 - 1.334 1.003 -1.181