ENSG00000110057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000227471 ENSG00000110057 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC93B1 protein_coding protein_coding 11.24625 18.21366 6.206063 1.414763 0.08585883 -1.55174 9.9296054 17.68459284 5.2939655 1.51805664 0.08244573 -1.738165 0.85334583 0.969700000 0.85323333 -0.1164667 7.53789e-05 6.51269e-09 FALSE TRUE
ENST00000525368 ENSG00000110057 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC93B1 protein_coding retained_intron 11.24625 18.21366 6.206063 1.414763 0.08585883 -1.55174 0.4845327 0.00000000 0.0000000 0.00000000 0.00000000 0.000000 0.05015417 0.000000000 0.00000000 0.0000000   6.51269e-09 FALSE TRUE
ENST00000530138 ENSG00000110057 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC93B1 protein_coding retained_intron 11.24625 18.21366 6.206063 1.414763 0.08585883 -1.55174 0.1273019 0.03397841 0.4579159 0.03397841 0.07406607 3.411382 0.01771250 0.001666667 0.07396667 0.0723000 6.51269e-09 6.51269e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110057 E001 0.4470576 0.0217681645 0.100031875 0.190532451 11 67991100 67991103 4 - 0.348 0.069 -2.832
ENSG00000110057 E002 117.7391309 0.0003088778 0.109872023 0.205361840 11 67991104 67991362 259 - 1.914 1.977 0.211
ENSG00000110057 E003 221.6463349 0.0002085008 0.066847344 0.138132950 11 67991363 67991817 455 - 2.194 2.245 0.170
ENSG00000110057 E004 81.1098781 0.0058675186 0.071875461 0.146463773 11 67991818 67991857 40 - 1.705 1.821 0.391
ENSG00000110057 E005 142.0877170 0.0002983994 0.081401977 0.161754603 11 67993676 67993794 119 - 1.991 2.054 0.210
ENSG00000110057 E006 195.1251525 0.0010982429 0.022106279 0.055893981 11 67995611 67995884 274 - 2.116 2.194 0.261
ENSG00000110057 E007 0.0000000       11 67995885 67995980 96 -      
ENSG00000110057 E008 133.6363551 0.0003662432 0.116476793 0.214925430 11 67996602 67996771 170 - 1.969 2.027 0.196
ENSG00000110057 E009 61.6550435 0.0004569897 0.193496832 0.318167882 11 67996772 67996784 13 - 1.745 1.675 -0.239
ENSG00000110057 E010 2.4710397 0.1043611979 0.206186207 0.333929241 11 67997558 67997674 117 - 0.670 0.428 -1.135
ENSG00000110057 E011 93.7125531 0.0021304847 0.112902761 0.209777163 11 67997675 67997799 125 - 1.930 1.854 -0.253
ENSG00000110057 E012 53.2050910 0.0010837164 0.169884117 0.288059613 11 67998359 67998376 18 - 1.689 1.608 -0.274
ENSG00000110057 E013 50.4402882 0.0005914559 0.087352065 0.171122646 11 67998377 67998386 10 - 1.683 1.583 -0.341
ENSG00000110057 E014 74.7712358 0.0003751915 0.468897919 0.608250281 11 67998387 67998452 66 - 1.799 1.762 -0.125
ENSG00000110057 E015 38.3921346 0.0005534815 0.616701427 0.734706137 11 67999173 67999175 3 - 1.457 1.490 0.114
ENSG00000110057 E016 82.8564004 0.0005882587 0.327864931 0.471338804 11 67999176 67999305 130 - 1.855 1.807 -0.159
ENSG00000110057 E017 1.1351654 0.0517850633 0.625016109 0.741213829 11 67999306 67999315 10 - 0.208 0.307 0.746
ENSG00000110057 E018 2.6421349 0.2406578361 0.356812413 0.501194030 11 67999316 67999375 60 - 0.669 0.449 -1.018
ENSG00000110057 E019 3.4718199 0.0051812344 0.001092344 0.004278120 11 67999376 67999518 143 - 0.922 0.435 -2.094
ENSG00000110057 E020 92.0485767 0.0020610489 0.030072181 0.072095829 11 67999519 67999680 162 - 1.942 1.841 -0.342
ENSG00000110057 E021 88.2066581 0.0003498329 0.164457888 0.280979300 11 68003022 68003175 154 - 1.890 1.827 -0.214
ENSG00000110057 E022 1.2814720 0.0896614852 0.024857614 0.061576689 11 68003176 68003656 481 - 0.609 0.182 -2.562
ENSG00000110057 E023 69.9428517 0.0080817195 0.572162028 0.698314609 11 68003657 68003798 142 - 1.768 1.733 -0.119
ENSG00000110057 E024 2.8785323 0.0053895862 0.002325467 0.008229401 11 68003799 68003947 149 - 0.853 0.377 -2.153
ENSG00000110057 E025 40.5139171 0.0196695103 0.600967948 0.722142707 11 68003948 68004107 160 - 1.533 1.498 -0.119
ENSG00000110057 E026 0.0000000       11 68004807 68004982 176 -