ENSG00000110046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377264 ENSG00000110046 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG2A protein_coding protein_coding 16.35507 27.52561 9.125325 2.166786 0.2853909 -1.59177 0.8646937 0.000000 0.8495364 0.00000000 0.4494959 6.42548684 0.09066667 0.00000000 0.09153333 0.09153333 9.005886e-02 2.130311e-05 FALSE TRUE
ENST00000418259 ENSG00000110046 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG2A protein_coding protein_coding 16.35507 27.52561 9.125325 2.166786 0.2853909 -1.59177 3.8870743 8.295698 1.3716881 0.56786084 0.1481808 -2.58766936 0.19807083 0.30290000 0.14970000 -0.15320000 2.130311e-05 2.130311e-05 FALSE TRUE
ENST00000421419 ENSG00000110046 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG2A protein_coding protein_coding 16.35507 27.52561 9.125325 2.166786 0.2853909 -1.59177 3.9076248 9.294231 0.9850258 0.09376803 0.2054905 -3.22508114 0.18582500 0.34170000 0.10856667 -0.23313333 2.424103e-05 2.130311e-05 FALSE TRUE
MSTRG.5688.4 ENSG00000110046 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG2A protein_coding   16.35507 27.52561 9.125325 2.166786 0.2853909 -1.59177 0.7655789 0.000000 0.5588816 0.00000000 0.5588816 5.83005639 0.08514167 0.00000000 0.06396667 0.06396667 6.967868e-01 2.130311e-05 FALSE TRUE
MSTRG.5688.5 ENSG00000110046 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG2A protein_coding   16.35507 27.52561 9.125325 2.166786 0.2853909 -1.59177 2.9005209 4.624281 0.9368173 1.09247280 0.9368173 -2.29118772 0.15081667 0.16353333 0.10456667 -0.05896667 2.403310e-01 2.130311e-05 FALSE TRUE
MSTRG.5688.6 ENSG00000110046 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG2A protein_coding   16.35507 27.52561 9.125325 2.166786 0.2853909 -1.59177 1.7270340 2.355922 2.4961104 0.37997886 0.7250357 0.08304778 0.12906667 0.08573333 0.27010000 0.18436667 2.137525e-02 2.130311e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000110046 E001 9.4778746 0.0017835730 1.462371e-01 2.565630e-01 11 64894546 64894571 26 - 0.786 0.974 0.721
ENSG00000110046 E002 77.1731458 0.0107298821 3.299304e-03 1.114709e-02 11 64894572 64894684 113 - 1.633 1.847 0.725
ENSG00000110046 E003 79.0597672 0.0066948219 2.750215e-04 1.278075e-03 11 64894685 64894702 18 - 1.622 1.860 0.807
ENSG00000110046 E004 116.2835307 0.0090222154 5.663553e-03 1.772288e-02 11 64894703 64894732 30 - 1.842 2.016 0.584
ENSG00000110046 E005 158.2412358 0.0060646048 5.693497e-05 3.162169e-04 11 64894733 64894778 46 - 1.940 2.154 0.715
ENSG00000110046 E006 411.3727740 0.0033955800 3.709659e-08 4.102127e-07 11 64894779 64895209 431 - 2.366 2.563 0.656
ENSG00000110046 E007 187.5970815 0.0002066460 5.780750e-08 6.143530e-07 11 64895290 64895442 153 - 2.036 2.214 0.595
ENSG00000110046 E008 191.3756940 0.0002535107 7.636352e-07 6.508093e-06 11 64896462 64896616 155 - 2.063 2.222 0.533
ENSG00000110046 E009 162.3333042 0.0027967127 2.896075e-04 1.337623e-03 11 64896748 64896847 100 - 1.998 2.154 0.521
ENSG00000110046 E010 105.2297928 0.0047389876 2.318732e-02 5.813923e-02 11 64896848 64896869 22 - 1.843 1.964 0.408
ENSG00000110046 E011 5.6851458 0.0028377954 1.514958e-05 9.659538e-05 11 64897040 64897411 372 - 1.111 0.558 -2.186
ENSG00000110046 E012 166.1369458 0.0110042160 2.905262e-01 4.313459e-01 11 64897412 64897494 83 - 2.085 2.150 0.216
ENSG00000110046 E013 177.5013190 0.0024979119 7.439513e-02 1.505712e-01 11 64897671 64897743 73 - 2.107 2.177 0.235
ENSG00000110046 E014 219.2507509 0.0017855013 2.119423e-02 5.400454e-02 11 64897839 64897974 136 - 2.189 2.270 0.269
ENSG00000110046 E015 157.9584218 0.0002585770 1.559237e-04 7.734615e-04 11 64898086 64898170 85 - 2.003 2.135 0.440
ENSG00000110046 E016 126.1435719 0.0002828401 5.002127e-05 2.819260e-04 11 64898261 64898362 102 - 1.883 2.043 0.536
ENSG00000110046 E017 165.5101498 0.0009674601 1.561575e-04 7.745237e-04 11 64898636 64898842 207 - 2.013 2.153 0.469
ENSG00000110046 E018 128.7015984 0.0009059138 2.755067e-04 1.280010e-03 11 64900494 64900629 136 - 1.899 2.048 0.499
ENSG00000110046 E019 175.9830877 0.0002527565 9.540308e-02 1.834962e-01 11 64900884 64901092 209 - 2.113 2.164 0.172
ENSG00000110046 E020 181.3679661 0.0003010031 9.342414e-01 9.625545e-01 11 64901962 64902176 215 - 2.168 2.168 -0.001
ENSG00000110046 E021 86.5256784 0.0003232682 2.249489e-01 3.563557e-01 11 64902260 64902386 127 - 1.810 1.862 0.177
ENSG00000110046 E022 10.9516179 0.0017354920 1.098512e-01 2.053462e-01 11 64902510 64902515 6 - 0.824 1.023 0.750
ENSG00000110046 E023 50.7967105 0.0004472961 5.658603e-02 1.207336e-01 11 64902516 64902680 165 - 1.530 1.643 0.387
ENSG00000110046 E024 82.9183077 0.0050221904 8.481152e-01 9.057152e-01 11 64903288 64903364 77 - 1.828 1.839 0.036
ENSG00000110046 E025 71.4973101 0.0191036384 3.152491e-01 4.580033e-01 11 64903590 64903660 71 - 1.707 1.791 0.284
ENSG00000110046 E026 110.8782654 0.0128817527 4.693356e-01 6.085892e-01 11 64905563 64905655 93 - 1.999 1.951 -0.162
ENSG00000110046 E027 102.6409559 0.0026734635 3.358157e-01 4.796382e-01 11 64905742 64905848 107 - 1.963 1.917 -0.154
ENSG00000110046 E028 78.7814754 0.0003511337 3.370614e-01 4.809238e-01 11 64906113 64906193 81 - 1.846 1.799 -0.161
ENSG00000110046 E029 119.7762600 0.0003399017 1.356990e-01 2.420853e-01 11 64906334 64906533 200 - 2.034 1.975 -0.199
ENSG00000110046 E030 107.8576313 0.0002598335 5.330112e-02 1.150254e-01 11 64906665 64906815 151 - 2.006 1.927 -0.264
ENSG00000110046 E031 115.1039591 0.0002610002 8.466271e-02 1.668549e-01 11 64907255 64907415 161 - 2.025 1.956 -0.231
ENSG00000110046 E032 4.4020972 0.0404434628 3.233250e-01 4.666394e-01 11 64907416 64907439 24 - 0.785 0.622 -0.679
ENSG00000110046 E033 92.8940847 0.0006974898 5.961723e-01 7.181520e-01 11 64907525 64907664 140 - 1.863 1.884 0.071
ENSG00000110046 E034 100.7159452 0.0009373903 4.114294e-01 5.549951e-01 11 64907748 64907890 143 - 1.946 1.908 -0.127
ENSG00000110046 E035 103.2616790 0.0002751059 1.521322e-05 9.695222e-05 11 64908991 64909150 160 - 2.054 1.884 -0.572
ENSG00000110046 E036 74.2993176 0.0003846345 1.014841e-03 4.010067e-03 11 64909271 64909367 97 - 1.899 1.745 -0.519
ENSG00000110046 E037 108.5173093 0.0221806893 1.028394e-01 1.948125e-01 11 64909681 64909924 244 - 2.042 1.922 -0.403
ENSG00000110046 E038 99.6746978 0.0248689337 1.284176e-01 2.319502e-01 11 64910040 64910195 156 - 1.998 1.888 -0.369
ENSG00000110046 E039 85.0201609 0.0217465666 9.877079e-02 1.886102e-01 11 64910616 64910708 93 - 1.937 1.816 -0.408
ENSG00000110046 E040 102.3768640 0.0173074391 1.838411e-02 4.797594e-02 11 64910807 64910954 148 - 2.047 1.884 -0.547
ENSG00000110046 E041 115.5903500 0.0064229291 2.274267e-07 2.157285e-06 11 64911038 64911275 238 - 2.166 1.903 -0.882
ENSG00000110046 E042 83.8319206 0.0003834247 1.397785e-10 2.406892e-09 11 64911842 64911982 141 - 2.032 1.761 -0.912
ENSG00000110046 E043 82.5789466 0.0045759506 6.259679e-07 5.431583e-06 11 64912085 64912249 165 - 2.023 1.763 -0.874
ENSG00000110046 E044 58.2987792 0.0011233902 1.169355e-05 7.650600e-05 11 64912327 64912423 97 - 1.853 1.625 -0.773
ENSG00000110046 E045 2.9819751 0.0051176390 1.381209e-03 5.244751e-03 11 64912611 64913037 427 - 0.860 0.363 -2.253
ENSG00000110046 E046 54.3479479 0.0004690231 2.156811e-04 1.031215e-03 11 64913038 64913136 99 - 1.798 1.601 -0.669
ENSG00000110046 E047 62.8117263 0.0004235037 7.442152e-06 5.090787e-05 11 64913266 64913401 136 - 1.877 1.656 -0.746
ENSG00000110046 E048 14.7773511 0.0175973216 3.509545e-07 3.201583e-06 11 64913402 64913820 419 - 1.468 0.930 -1.915
ENSG00000110046 E049 62.1513197 0.0004110081 2.045737e-08 2.381020e-07 11 64913821 64913923 103 - 1.905 1.632 -0.923
ENSG00000110046 E050 0.1817044 0.0392621943 1.000000e+00   11 64913924 64914080 157 - 0.000 0.074 8.888
ENSG00000110046 E051 70.3472702 0.0008146869 3.696861e-06 2.713098e-05 11 64914081 64914195 115 - 1.923 1.703 -0.744
ENSG00000110046 E052 39.9452230 0.0034036851 4.312903e-05 2.467659e-04 11 64914196 64914208 13 - 1.716 1.450 -0.908
ENSG00000110046 E053 41.0717684 0.0058394911 2.632726e-04 1.229962e-03 11 64914209 64914233 25 - 1.721 1.470 -0.855
ENSG00000110046 E054 0.1817044 0.0392621943 1.000000e+00   11 64914234 64914337 104 - 0.000 0.074 8.888
ENSG00000110046 E055 84.5625465 0.0115094166 5.349458e-04 2.290619e-03 11 64914338 64914500 163 - 2.013 1.785 -0.765
ENSG00000110046 E056 0.4741261 0.0221384752 1.317156e-01 2.365113e-01 11 64916937 64916964 28 - 0.329 0.074 -2.601
ENSG00000110046 E057 73.1336831 0.0287560411 1.579083e-03 5.890918e-03 11 64916965 64917232 268 - 1.985 1.707 -0.938