ENSG00000109929

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264027 ENSG00000109929 HEK293_OSMI2_2hA HEK293_TMG_2hB SC5D protein_coding protein_coding 51.7965 11.32503 85.47943 1.112261 5.296756 2.914958 10.699212 3.416755 17.54411 0.2927813 0.8566534 2.356894 0.2391625 0.3036667 0.2057 -0.09796667 0.007004978 0.007004978 FALSE  
ENST00000527762 ENSG00000109929 HEK293_OSMI2_2hA HEK293_TMG_2hB SC5D protein_coding protein_coding 51.7965 11.32503 85.47943 1.112261 5.296756 2.914958 13.493234 2.657758 21.34789 0.0691784 0.4848676 3.001069 0.2689667 0.2386000 0.2523 0.01370000 0.892915211 0.007004978 FALSE  
ENST00000528991 ENSG00000109929 HEK293_OSMI2_2hA HEK293_TMG_2hB SC5D protein_coding processed_transcript 51.7965 11.32503 85.47943 1.112261 5.296756 2.914958 19.280067 3.859205 30.07885 1.0771796 3.9989243 2.959120 0.3513500 0.3295667 0.3489 0.01933333 0.924130942 0.007004978    
ENST00000531140 ENSG00000109929 HEK293_OSMI2_2hA HEK293_TMG_2hB SC5D protein_coding retained_intron 51.7965 11.32503 85.47943 1.112261 5.296756 2.914958 7.355501 1.070213 14.74787 0.3072684 1.4287274 3.772096 0.1188750 0.1009667 0.1722 0.07123333 0.376558796 0.007004978 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109929 E001 6.3150232 0.0102262548 1.723802e-01 2.913039e-01 11 121292681 121292758 78 + 0.815 0.592 -0.926
ENSG00000109929 E002 6.8331565 0.0040090417 2.633054e-01 4.011841e-01 11 121292759 121292770 12 + 0.834 0.666 -0.678
ENSG00000109929 E003 70.9510209 0.0195004156 6.698358e-03 2.044111e-02 11 121292771 121292816 46 + 1.795 1.549 -0.833
ENSG00000109929 E004 3.3764055 0.1513709200 6.544081e-02 1.357759e-01 11 121292852 121293078 227 + 0.460 0.868 1.759
ENSG00000109929 E005 316.5604701 0.0010834210 6.028433e-04 2.543518e-03 11 121303366 121303585 220 + 2.417 2.328 -0.297
ENSG00000109929 E006 0.7792333 0.0259233243 8.698189e-01 9.202727e-01 11 121303586 121304339 754 + 0.199 0.238 0.322
ENSG00000109929 E007 0.5932625 0.1810237442 5.962648e-01 7.182360e-01 11 121304340 121304360 21 + 0.199 0.000 -9.393
ENSG00000109929 E008 185.0350569 0.0005325125 3.139467e-03 1.067547e-02 11 121304361 121304384 24 + 2.185 2.093 -0.305
ENSG00000109929 E009 235.6868551 0.0001894923 1.824910e-01 3.043449e-01 11 121304385 121304493 109 + 2.278 2.254 -0.082
ENSG00000109929 E010 5.5064358 0.0382243636 9.835534e-04 3.903369e-03 11 121304494 121305710 1217 + 0.806 0.000 -13.133
ENSG00000109929 E011 5.7117459 0.0029832141 2.759662e-02 6.720609e-02 11 121305750 121306385 636 + 0.795 0.390 -1.848
ENSG00000109929 E012 202.9335904 0.0002091378 5.374978e-01 6.690501e-01 11 121306386 121306458 73 + 2.210 2.205 -0.016
ENSG00000109929 E013 183.6856754 0.0009303562 1.601473e-01 2.753150e-01 11 121306459 121306486 28 + 2.173 2.137 -0.121
ENSG00000109929 E014 5.2292112 0.0032198913 3.881146e-01 5.322346e-01 11 121306487 121306741 255 + 0.730 0.592 -0.584
ENSG00000109929 E015 370.4609694 0.0001704908 1.114474e-01 2.076698e-01 11 121307057 121307243 187 + 2.474 2.452 -0.074
ENSG00000109929 E016 355.3654355 0.0001591751 8.765864e-01 9.247915e-01 11 121307244 121307456 213 + 2.449 2.467 0.062
ENSG00000109929 E017 1460.3823832 0.0008557636 9.486843e-09 1.175214e-07 11 121307457 121313410 5954 + 3.047 3.128 0.269