ENSG00000109920

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263773 ENSG00000109920 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP4 protein_coding protein_coding 45.89574 18.26384 63.44198 2.333549 1.117882 1.795885 13.886987 9.8821279 17.245549 0.03137832 0.4479504 0.8027076 0.35849167 0.56100000 0.27186667 -0.28913333 0.008155585 2.663585e-17 FALSE TRUE
ENST00000363220 ENSG00000109920 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP4 protein_coding misc_RNA 45.89574 18.26384 63.44198 2.333549 1.117882 1.795885 12.708475 2.5241662 13.401065 1.27426139 1.3303003 2.4038407 0.24091667 0.12310000 0.21120000 0.08810000 0.717274716 2.663585e-17   FALSE
ENST00000529156 ENSG00000109920 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP4 protein_coding processed_transcript 45.89574 18.26384 63.44198 2.333549 1.117882 1.795885 3.116611 1.0637140 5.877931 0.25001119 0.7391191 2.4551509 0.05955417 0.05643333 0.09233333 0.03590000 0.148520388 2.663585e-17   FALSE
ENST00000530207 ENSG00000109920 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP4 protein_coding retained_intron 45.89574 18.26384 63.44198 2.333549 1.117882 1.795885 2.889164 0.8178778 4.539739 0.08822692 0.2499978 2.4582940 0.06073750 0.04520000 0.07163333 0.02643333 0.048411319 2.663585e-17 FALSE FALSE
ENST00000534003 ENSG00000109920 HEK293_OSMI2_2hA HEK293_TMG_2hB FNBP4 protein_coding processed_transcript 45.89574 18.26384 63.44198 2.333549 1.117882 1.795885 2.678752 0.6588872 4.831371 0.03014601 0.4097397 2.8555807 0.05242500 0.03693333 0.07596667 0.03903333 0.001853426 2.663585e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109920 E001 314.5855839 0.0062747123 1.849806e-10 3.116685e-09 11 47716494 47717047 554 - 2.364 2.634 0.902
ENSG00000109920 E002 104.9827525 0.0010384460 3.813544e-08 4.208449e-07 11 47717048 47717069 22 - 1.922 2.130 0.698
ENSG00000109920 E003 106.8548995 0.0004055964 7.144437e-08 7.460545e-07 11 47717070 47717096 27 - 1.938 2.130 0.642
ENSG00000109920 E004 138.6503655 0.0008709596 6.205664e-07 5.389156e-06 11 47717097 47717133 37 - 2.060 2.227 0.560
ENSG00000109920 E005 131.9282232 0.0003029750 2.654784e-07 2.483904e-06 11 47717134 47717184 51 - 2.038 2.204 0.554
ENSG00000109920 E006 111.9816755 0.0003132309 6.634232e-07 5.725380e-06 11 47717185 47717226 42 - 1.962 2.135 0.580
ENSG00000109920 E007 270.6133580 0.0001911677 3.539548e-18 1.821670e-16 11 47717227 47717512 286 - 2.336 2.529 0.645
ENSG00000109920 E008 181.7254834 0.0021008675 1.477859e-04 7.375357e-04 11 47719929 47720086 158 - 2.194 2.327 0.444
ENSG00000109920 E009 78.4586830 0.0011533594 2.717499e-03 9.425523e-03 11 47722976 47722981 6 - 1.834 1.965 0.443
ENSG00000109920 E010 251.1214016 0.0021516897 2.161196e-05 1.329196e-04 11 47722982 47723316 335 - 2.331 2.466 0.451
ENSG00000109920 E011 155.9907266 0.0002364961 8.086544e-02 1.608913e-01 11 47724028 47724172 145 - 2.159 2.213 0.180
ENSG00000109920 E012 68.3647049 0.0025575919 6.519586e-01 7.627281e-01 11 47724468 47724471 4 - 1.818 1.844 0.088
ENSG00000109920 E013 87.7939797 0.0015562267 2.211574e-01 3.518147e-01 11 47724472 47724503 32 - 1.912 1.968 0.187
ENSG00000109920 E014 186.2158907 0.0003262827 1.067524e-01 2.007556e-01 11 47724504 47724778 275 - 2.238 2.285 0.157
ENSG00000109920 E015 73.7955839 0.0004878366 8.037242e-16 3.072299e-14 11 47724779 47725736 958 - 1.968 1.579 -1.316
ENSG00000109920 E016 46.5801268 0.0023288941 6.068083e-05 3.348032e-04 11 47725737 47725836 100 - 1.736 1.492 -0.830
ENSG00000109920 E017 76.7764778 0.0003862473 6.647361e-17 2.924576e-15 11 47725837 47726893 1057 - 1.985 1.590 -1.336
ENSG00000109920 E018 19.0950360 0.0525826799 5.040051e-03 1.604016e-02 11 47726894 47726992 99 - 1.400 1.010 -1.383
ENSG00000109920 E019 14.2368193 0.0196859052 7.508636e-08 7.812437e-07 11 47729932 47729967 36 - 1.331 0.576 -2.885
ENSG00000109920 E020 12.8026965 0.0210001305 3.613543e-06 2.657202e-05 11 47729968 47730001 34 - 1.277 0.626 -2.473
ENSG00000109920 E021 27.0939998 0.0149734368 4.710996e-08 5.108667e-07 11 47730002 47730187 186 - 1.577 1.008 -1.998
ENSG00000109920 E022 7.8744441 0.0062687019 6.202630e-02 1.300330e-01 11 47730188 47730190 3 - 1.017 0.783 -0.891
ENSG00000109920 E023 11.9779063 0.0014579947 7.038198e-09 8.927790e-08 11 47731284 47731373 90 - 1.260 0.520 -2.897
ENSG00000109920 E024 179.1555090 0.0009587444 9.545588e-02 1.835641e-01 11 47731374 47731561 188 - 2.258 2.208 -0.166
ENSG00000109920 E025 28.1226915 0.0007321713 1.420760e-07 1.402088e-06 11 47731562 47731562 1 - 1.560 1.158 -1.399
ENSG00000109920 E026 31.8847144 0.0165943644 1.728349e-03 6.372413e-03 11 47731788 47731832 45 - 1.584 1.295 -0.999
ENSG00000109920 E027 22.0498031 0.0213882382 3.530380e-03 1.181369e-02 11 47731833 47731839 7 - 1.438 1.118 -1.124
ENSG00000109920 E028 55.7447715 0.0339932193 1.984620e-03 7.178621e-03 11 47731840 47732032 193 - 1.828 1.518 -1.055
ENSG00000109920 E029 28.9397114 0.0399718271 1.068417e-02 3.041632e-02 11 47732033 47732116 84 - 1.547 1.246 -1.041
ENSG00000109920 E030 59.6749833 0.0468663128 3.464257e-01 4.905544e-01 11 47732117 47732219 103 - 1.791 1.717 -0.252
ENSG00000109920 E031 49.2991360 0.0004439112 6.821309e-08 7.155859e-07 11 47732220 47732481 262 - 1.776 1.472 -1.036
ENSG00000109920 E032 32.8413410 0.0006300285 1.419754e-05 9.103676e-05 11 47732482 47732536 55 - 1.604 1.309 -1.016
ENSG00000109920 E033 156.0304945 0.0014013847 7.144129e-02 1.457295e-01 11 47732537 47732670 134 - 2.201 2.141 -0.201
ENSG00000109920 E034 133.1469325 0.0017593157 1.828156e-01 3.047281e-01 11 47734025 47734129 105 - 2.130 2.082 -0.162
ENSG00000109920 E035 0.3268771 0.0300147219 6.109302e-01   11 47734130 47734135 6 - 0.090 0.165 1.008
ENSG00000109920 E036 141.0226868 0.0039722504 2.129857e-02 5.421717e-02 11 47736616 47736740 125 - 2.173 2.073 -0.334
ENSG00000109920 E037 3.2313440 0.0085683599 1.771711e-02 4.652436e-02 11 47743817 47743952 136 - 0.452 0.815 1.593
ENSG00000109920 E038 198.8499989 0.0063712053 1.788042e-01 2.996475e-01 11 47743953 47744163 211 - 2.309 2.248 -0.203
ENSG00000109920 E039 258.1548529 0.0040676214 5.796016e-01 7.044569e-01 11 47746056 47746394 339 - 2.407 2.389 -0.061
ENSG00000109920 E040 136.2546622 0.0059839063 3.568470e-01 5.012388e-01 11 47750916 47751036 121 - 2.138 2.094 -0.146
ENSG00000109920 E041 171.3710151 0.0008858285 1.728612e-02 4.557771e-02 11 47751143 47751290 148 - 2.246 2.173 -0.243
ENSG00000109920 E042 0.8909948 0.0136968632 3.646611e-01 5.090024e-01 11 47752720 47752915 196 - 0.332 0.165 -1.312
ENSG00000109920 E043 115.4393548 0.0002575324 5.408094e-04 2.312695e-03 11 47752916 47752986 71 - 2.092 1.972 -0.402
ENSG00000109920 E044 104.1707246 0.0003195286 4.298669e-03 1.398036e-02 11 47752987 47753037 51 - 2.045 1.941 -0.347
ENSG00000109920 E045 101.3862202 0.0004181247 4.041351e-03 1.325775e-02 11 47753038 47753102 65 - 2.034 1.927 -0.358
ENSG00000109920 E046 133.0917950 0.0037428704 9.278462e-04 3.712384e-03 11 47754528 47754664 137 - 2.161 2.018 -0.481
ENSG00000109920 E047 93.0899712 0.0051692770 5.126662e-05 2.881135e-04 11 47765270 47765362 93 - 2.027 1.813 -0.719
ENSG00000109920 E048 4.9283810 0.0223805734 2.391099e-01 3.730649e-01 11 47767063 47767068 6 - 0.814 0.628 -0.763
ENSG00000109920 E049 83.8700070 0.0120088716 2.232063e-03 7.942628e-03 11 47767069 47767582 514 - 1.979 1.774 -0.690