ENSG00000109919

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302503 ENSG00000109919 HEK293_OSMI2_2hA HEK293_TMG_2hB MTCH2 protein_coding protein_coding 193.8506 284.1424 146.5393 21.98266 1.461612 -0.9552788 14.29751 14.79870 18.57151 2.316360 1.1561525 0.3274226 0.08090417 0.05173333 0.1267000 0.07496667 1.666877e-07 1.666877e-07 FALSE  
MSTRG.5479.12 ENSG00000109919 HEK293_OSMI2_2hA HEK293_TMG_2hB MTCH2 protein_coding   193.8506 284.1424 146.5393 21.98266 1.461612 -0.9552788 40.72315 54.52525 30.10012 3.801194 2.1552347 -0.8569406 0.21372500 0.19263333 0.2053667 0.01273333 8.342244e-01 1.666877e-07 FALSE  
MSTRG.5479.7 ENSG00000109919 HEK293_OSMI2_2hA HEK293_TMG_2hB MTCH2 protein_coding   193.8506 284.1424 146.5393 21.98266 1.461612 -0.9552788 59.64420 97.11156 41.03920 7.440491 1.6222790 -1.2424376 0.29936250 0.34273333 0.2800667 -0.06266667 1.071474e-01 1.666877e-07 FALSE  
MSTRG.5479.8 ENSG00000109919 HEK293_OSMI2_2hA HEK293_TMG_2hB MTCH2 protein_coding   193.8506 284.1424 146.5393 21.98266 1.461612 -0.9552788 73.64044 113.59710 51.40062 10.483024 0.2515536 -1.1439147 0.37543333 0.39923333 0.3508333 -0.04840000 1.479666e-01 1.666877e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109919 E001 3.6231082 0.2008979650 6.641613e-02 1.374203e-01 11 47606019 47606095 77 - 0.872 0.507 -1.544
ENSG00000109919 E002 2.7010072 0.0891500129 5.505661e-02 1.180955e-01 11 47606096 47606127 32 - 0.776 0.424 -1.584
ENSG00000109919 E003 5.7632079 0.0828715252 7.488742e-03 2.248332e-02 11 47606128 47606254 127 - 1.076 0.632 -1.734
ENSG00000109919 E004 0.1482932 0.0408312882 1.000000e+00   11 47617315 47617316 2 - 0.001 0.084 7.376
ENSG00000109919 E005 81.8300322 0.0095877365 1.756999e-05 1.103605e-04 11 47617317 47617539 223 - 2.054 1.780 -0.921
ENSG00000109919 E006 545.6151131 0.0061170673 3.728610e-21 2.725208e-19 11 47617540 47618703 1164 - 2.940 2.538 -1.341
ENSG00000109919 E007 968.0711931 0.0002041170 5.719079e-09 7.388587e-08 11 47618704 47618838 135 - 2.887 2.953 0.220
ENSG00000109919 E008 1300.7524946 0.0007811329 1.500776e-09 2.153269e-08 11 47618839 47618919 81 - 2.998 3.083 0.281
ENSG00000109919 E009 966.1260954 0.0000923684 3.569618e-10 5.739716e-09 11 47622701 47622710 10 - 2.886 2.953 0.223
ENSG00000109919 E010 1609.7220835 0.0001425570 9.617875e-13 2.369412e-11 11 47622711 47622776 66 - 3.111 3.172 0.205
ENSG00000109919 E011 1559.1588423 0.0002559858 5.152995e-09 6.708950e-08 11 47625674 47625741 68 - 3.102 3.156 0.179
ENSG00000109919 E012 1408.8121532 0.0002593231 1.223152e-03 4.719015e-03 11 47627080 47627127 48 - 3.081 3.105 0.078
ENSG00000109919 E013 1668.1111698 0.0002913065 1.621104e-02 4.319031e-02 11 47628953 47629023 71 - 3.163 3.174 0.037
ENSG00000109919 E014 1183.0042464 0.0002526817 7.272564e-02 1.478834e-01 11 47629024 47629046 23 - 3.053 3.012 -0.136
ENSG00000109919 E015 3.4697952 0.0623472383 5.045943e-05 2.841363e-04 11 47629047 47629355 309 - 0.997 0.270 -3.375
ENSG00000109919 E016 1399.5453370 0.0001835726 9.361101e-01 9.638219e-01 11 47630555 47630614 60 - 3.107 3.090 -0.058
ENSG00000109919 E017 1230.3086847 0.0005634268 5.618983e-02 1.200329e-01 11 47631036 47631087 52 - 3.074 3.024 -0.165
ENSG00000109919 E018 1288.8406348 0.0002944374 4.085140e-01 5.521199e-01 11 47631654 47631711 58 - 3.080 3.051 -0.099
ENSG00000109919 E019 1314.8793404 0.0003702400 3.030534e-01 4.449696e-01 11 47634672 47634734 63 - 3.091 3.057 -0.114
ENSG00000109919 E020 802.8419075 0.0002461669 6.766463e-01 7.815663e-01 11 47635545 47635571 27 - 2.871 2.847 -0.082
ENSG00000109919 E021 1630.9664624 0.0019927686 1.927214e-01 3.171847e-01 11 47638699 47638805 107 - 3.197 3.143 -0.181
ENSG00000109919 E022 1400.3386346 0.0026085956 1.070011e-01 2.011059e-01 11 47638967 47639051 85 - 3.140 3.073 -0.222
ENSG00000109919 E023 821.1615972 0.0017957366 4.732070e-02 1.044038e-01 11 47642379 47642400 22 - 2.912 2.841 -0.236
ENSG00000109919 E024 1093.6884746 0.0039669600 3.203568e-02 7.592483e-02 11 47642401 47642608 208 - 3.051 2.957 -0.313