ENSG00000109861

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000227266 ENSG00000109861 HEK293_OSMI2_2hA HEK293_TMG_2hB CTSC protein_coding protein_coding 36.05043 37.10046 37.24207 2.054859 1.305975 0.005494762 18.906033 13.225908 23.7847804 1.4871507 0.1191712 0.8461880 0.49530000 0.3544667 0.64033333 0.28586667 8.863183e-09 8.863183e-09 FALSE TRUE
ENST00000528020 ENSG00000109861 HEK293_OSMI2_2hA HEK293_TMG_2hB CTSC protein_coding protein_coding 36.05043 37.10046 37.24207 2.054859 1.305975 0.005494762 3.461757 5.230497 1.4524194 0.3343131 0.8442770 -1.8413464 0.09940833 0.1408667 0.04036667 -0.10050000 4.060791e-01 8.863183e-09   FALSE
ENST00000529974 ENSG00000109861 HEK293_OSMI2_2hA HEK293_TMG_2hB CTSC protein_coding protein_coding 36.05043 37.10046 37.24207 2.054859 1.305975 0.005494762 2.550876 4.247873 1.9977604 0.5721082 0.7377182 -1.0845458 0.08285000 0.1166667 0.05243333 -0.06423333 1.706801e-01 8.863183e-09 FALSE TRUE
ENST00000677106 ENSG00000109861 HEK293_OSMI2_2hA HEK293_TMG_2hB CTSC protein_coding protein_coding 36.05043 37.10046 37.24207 2.054859 1.305975 0.005494762 2.648906 4.510294 0.8864489 0.5195544 0.8864489 -2.3341233 0.07431667 0.1210333 0.02476667 -0.09626667 9.089837e-02 8.863183e-09 FALSE TRUE
ENST00000677796 ENSG00000109861 HEK293_OSMI2_2hA HEK293_TMG_2hB CTSC protein_coding nonsense_mediated_decay 36.05043 37.10046 37.24207 2.054859 1.305975 0.005494762 4.846387 6.073792 5.3436761 0.8510004 1.5447008 -0.1844409 0.14388333 0.1631333 0.14106667 -0.02206667 8.109241e-01 8.863183e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109861 E001 0.2998086 0.0282279446 9.138551e-01   11 88265069 88265226 158 - 0.115 0.130 0.195
ENSG00000109861 E002 0.5932745 0.0205908217 8.826016e-01 9.288549e-01 11 88290402 88290507 106 - 0.206 0.229 0.194
ENSG00000109861 E003 3.1441037 0.0048341713 2.198797e-03 7.838535e-03 11 88292494 88293591 1098 - 0.811 0.311 -2.388
ENSG00000109861 E004 0.0000000       11 88293592 88293594 3 -      
ENSG00000109861 E005 60.7797364 0.0004037761 4.838245e-01 6.218518e-01 11 88293595 88293761 167 - 1.782 1.804 0.074
ENSG00000109861 E006 155.0697156 0.0007210659 9.209462e-01 9.541154e-01 11 88293762 88293942 181 - 2.199 2.192 -0.024
ENSG00000109861 E007 380.3058515 0.0036127000 2.325811e-02 5.828269e-02 11 88293943 88294475 533 - 2.624 2.544 -0.266
ENSG00000109861 E008 109.2142949 0.0067599570 8.438261e-03 2.488150e-02 11 88294476 88294508 33 - 2.115 1.971 -0.480
ENSG00000109861 E009 2.0411123 0.0075203852 9.109120e-02 1.768475e-01 11 88295563 88296132 570 - 0.606 0.311 -1.539
ENSG00000109861 E010 179.2379176 0.0057502481 3.416038e-04 1.546599e-03 11 88296133 88296264 132 - 2.337 2.170 -0.556
ENSG00000109861 E011 13.9737466 0.0012343819 4.193898e-09 5.536349e-08 11 88296265 88299259 2995 - 1.382 0.794 -2.143
ENSG00000109861 E012 4.9918583 0.0031305535 3.509909e-05 2.051719e-04 11 88299260 88300529 1270 - 0.992 0.379 -2.660
ENSG00000109861 E013 155.2844819 0.0024351346 1.759960e-07 1.705207e-06 11 88300530 88300645 116 - 2.288 2.091 -0.659
ENSG00000109861 E014 167.2402642 0.0005475193 6.138829e-12 1.322172e-10 11 88309163 88309318 156 - 2.324 2.117 -0.692
ENSG00000109861 E015 0.1515154 0.0426391015 5.756233e-01   11 88309319 88309363 45 - 0.115 0.001 -7.977
ENSG00000109861 E016 73.4505988 0.0003507595 6.498876e-05 3.558566e-04 11 88312388 88312426 39 - 1.956 1.782 -0.585
ENSG00000109861 E017 63.3512827 0.0004305038 1.907207e-04 9.242677e-04 11 88312427 88312449 23 - 1.895 1.721 -0.588
ENSG00000109861 E018 104.7371641 0.0004635370 7.098541e-10 1.083815e-08 11 88312450 88312554 105 - 2.131 1.905 -0.759
ENSG00000109861 E019 1.2210915 0.0134568195 5.580180e-01 6.863218e-01 11 88315253 88316474 1222 - 0.281 0.379 0.615
ENSG00000109861 E020 78.1175394 0.0003350817 1.200366e-44 5.479658e-42 11 88320811 88326021 5211 - 2.117 1.481 -2.151
ENSG00000109861 E021 4.1716206 0.0514856178 2.123197e-01 3.412720e-01 11 88326022 88326085 64 - 0.811 0.580 -0.963
ENSG00000109861 E022 2.5098261 0.0090579737 2.390529e-01 3.730061e-01 11 88326086 88326086 1 - 0.638 0.438 -0.940
ENSG00000109861 E023 2.6549988 0.0060188722 1.679388e-01 2.855226e-01 11 88326087 88326087 1 - 0.667 0.438 -1.065
ENSG00000109861 E024 4.2706199 0.0038425844 8.682007e-01 9.192341e-01 11 88326088 88326093 6 - 0.745 0.714 -0.125
ENSG00000109861 E025 23.6013794 0.0206271187 2.012829e-04 9.692555e-04 11 88326094 88326139 46 - 1.175 1.534 1.250
ENSG00000109861 E026 178.4353129 0.0004570056 2.289101e-54 1.837556e-51 11 88326140 88326399 260 - 1.983 2.418 1.456
ENSG00000109861 E027 106.2442222 0.0003349676 1.984145e-29 3.153442e-27 11 88326400 88326443 44 - 1.789 2.182 1.322
ENSG00000109861 E028 0.4449813 0.0211484440 6.665743e-01 7.740052e-01 11 88327244 88327358 115 - 0.206 0.130 -0.804
ENSG00000109861 E029 2.5013278 0.0059297926 7.736361e-03 2.311683e-02 11 88327929 88328016 88 - 0.281 0.714 2.197
ENSG00000109861 E030 143.8668188 0.0004761483 1.578090e-34 3.746421e-32 11 88328112 88328196 85 - 1.933 2.307 1.252
ENSG00000109861 E031 2.1368644 0.0491106021 7.820986e-01 8.600865e-01 11 88328197 88330345 2149 - 0.535 0.487 -0.230
ENSG00000109861 E032 0.5181333 0.0217681645 6.710804e-01 7.774078e-01 11 88330346 88330645 300 - 0.206 0.130 -0.800
ENSG00000109861 E033 3.7606607 0.0558816016 1.995898e-03 7.213355e-03 11 88330646 88334936 4291 - 0.887 0.310 -2.688
ENSG00000109861 E034 250.4833545 0.0005275075 2.223396e-04 1.059316e-03 11 88334937 88335082 146 - 2.362 2.438 0.253
ENSG00000109861 E035 0.4783925 0.0221569071 6.703964e-01 7.768529e-01 11 88335083 88336472 1390 - 0.206 0.130 -0.802
ENSG00000109861 E036 0.4762024 0.2150607331 7.286917e-01 8.210914e-01 11 88337173 88337500 328 - 0.206 0.130 -0.798
ENSG00000109861 E037 141.3061753 0.0022913657 4.118181e-02 9.321807e-02 11 88337501 88337546 46 - 2.121 2.183 0.206
ENSG00000109861 E038 198.3383968 0.0043708578 1.691397e-01 2.870671e-01 11 88337547 88337683 137 - 2.281 2.318 0.124
ENSG00000109861 E039 114.5184866 0.0026189628 2.337524e-02 5.852831e-02 11 88337684 88337707 24 - 2.022 2.100 0.262
ENSG00000109861 E040 99.2054971 0.0021001271 1.927471e-01 3.172159e-01 11 88337708 88337780 73 - 1.980 2.020 0.136
ENSG00000109861 E041 0.0000000       11 88355532 88355759 228 -      
ENSG00000109861 E042 0.0000000       11 88355760 88355812 53 -      
ENSG00000109861 E043 0.0000000       11 88358874 88359007 134 -      
ENSG00000109861 E044 0.0000000       11 88359008 88359012 5 -      
ENSG00000109861 E045 0.0000000       11 88359013 88359252 240 -      
ENSG00000109861 E046 0.0000000       11 88359253 88359684 432 -