ENSG00000109814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316423 ENSG00000109814 HEK293_OSMI2_2hA HEK293_TMG_2hB UGDH protein_coding protein_coding 8.529569 4.416379 15.19959 0.6733472 0.5476012 1.780783 4.583154 4.0843554 7.653565 0.8204794 0.1627317 0.9043793 0.6311542 0.9171333 0.5051000 -0.4120333 2.935856e-02 8.097407e-05 FALSE TRUE
ENST00000507089 ENSG00000109814 HEK293_OSMI2_2hA HEK293_TMG_2hB UGDH protein_coding protein_coding 8.529569 4.416379 15.19959 0.6733472 0.5476012 1.780783 2.057595 0.2268904 4.028538 0.2268904 1.0117158 4.0915416 0.2166583 0.0576000 0.2659667 0.2083667 1.361457e-01 8.097407e-05 FALSE TRUE
MSTRG.24749.5 ENSG00000109814 HEK293_OSMI2_2hA HEK293_TMG_2hB UGDH protein_coding   8.529569 4.416379 15.19959 0.6733472 0.5476012 1.780783 1.489065 0.0000000 3.011993 0.0000000 1.4053630 8.2393565 0.1092417 0.0000000 0.1951667 0.1951667 8.097407e-05 8.097407e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109814 E001 0.5996172 0.2411543991 4.322331e-01 5.746819e-01 4 39498755 39498762 8 - 0.141 0.318 1.485
ENSG00000109814 E002 3.2704460 0.2260545111 8.780732e-02 1.717985e-01 4 39498763 39498787 25 - 0.437 0.863 1.858
ENSG00000109814 E003 148.5255542 0.0102701678 5.220853e-11 9.662710e-10 4 39498788 39499910 1123 - 1.986 2.374 1.299
ENSG00000109814 E004 43.5155969 0.0006349707 6.704820e-03 2.045753e-02 4 39499911 39499944 34 - 1.560 1.736 0.599
ENSG00000109814 E005 122.8395120 0.0007177624 8.059107e-04 3.279646e-03 4 39499945 39500253 309 - 2.013 2.155 0.477
ENSG00000109814 E006 81.9252461 0.0018984411 9.458462e-01 9.700051e-01 4 39503875 39503985 111 - 1.874 1.904 0.101
ENSG00000109814 E007 78.1658882 0.0003364555 4.567125e-01 5.971003e-01 4 39504417 39504508 92 - 1.844 1.903 0.196
ENSG00000109814 E008 74.0430694 0.0030252539 2.824899e-01 4.225044e-01 4 39505237 39505370 134 - 1.815 1.892 0.261
ENSG00000109814 E009 78.1403789 0.0029559970 9.430439e-01 9.682668e-01 4 39505618 39505748 131 - 1.857 1.876 0.065
ENSG00000109814 E010 66.2477528 0.0055733322 3.989857e-01 5.427345e-01 4 39508566 39508660 95 - 1.799 1.766 -0.111
ENSG00000109814 E011 88.5339678 0.0035857776 8.159226e-03 2.418659e-02 4 39509760 39509907 148 - 1.945 1.831 -0.383
ENSG00000109814 E012 100.9476463 0.0003100286 3.945966e-03 1.299095e-02 4 39510353 39510510 158 - 1.995 1.909 -0.290
ENSG00000109814 E013 63.3288962 0.0004172511 2.459580e-03 8.642653e-03 4 39510511 39510550 40 - 1.806 1.680 -0.424
ENSG00000109814 E014 44.0954979 0.0004934212 7.260183e-02 1.476771e-01 4 39510661 39510666 6 - 1.639 1.560 -0.270
ENSG00000109814 E015 57.4059012 0.0004635247 2.433883e-01 3.781518e-01 4 39510667 39510696 30 - 1.738 1.705 -0.113
ENSG00000109814 E016 48.0528135 0.0075665173 3.502534e-01 4.944447e-01 4 39510697 39510708 12 - 1.665 1.621 -0.148
ENSG00000109814 E017 50.5993141 0.0027473179 2.315664e-01 3.643379e-01 4 39510709 39510735 27 - 1.690 1.643 -0.157
ENSG00000109814 E018 66.9421960 0.0005262091 2.056697e-02 5.268615e-02 4 39510736 39510814 79 - 1.818 1.732 -0.291
ENSG00000109814 E019 51.3382645 0.0004387891 2.876810e-03 9.901778e-03 4 39510815 39510861 47 - 1.719 1.580 -0.475
ENSG00000109814 E020 31.5626227 0.0006811567 3.188678e-02 7.563454e-02 4 39514083 39514092 10 - 1.509 1.384 -0.432
ENSG00000109814 E021 57.1535367 0.0004602504 2.028195e-02 5.207429e-02 4 39514093 39514180 88 - 1.755 1.660 -0.321
ENSG00000109814 E022 31.7545303 0.0006208319 2.924408e-01 4.334040e-01 4 39514181 39514184 4 - 1.493 1.448 -0.155
ENSG00000109814 E023 31.6659486 0.0006719484 4.873723e-01 6.250441e-01 4 39521351 39521351 1 - 1.485 1.465 -0.070
ENSG00000109814 E024 73.1402015 0.0003911269 1.912047e-02 4.960105e-02 4 39521352 39521519 168 - 1.856 1.775 -0.275
ENSG00000109814 E025 0.0000000       4 39521520 39521544 25 -      
ENSG00000109814 E026 0.3268771 0.0343105060 4.591755e-01   4 39526384 39526557 174 - 0.076 0.191 1.526
ENSG00000109814 E027 0.7342825 0.0158950390 1.655885e-01 2.824743e-01 4 39527053 39527119 67 - 0.292 0.001 -9.354
ENSG00000109814 E028 0.6256415 0.0172671820 1.000000e+00 1.000000e+00 4 39527233 39527282 50 - 0.197 0.191 -0.060
ENSG00000109814 E029 54.5035506 0.0150896351 1.962988e-01 3.215917e-01 4 39527283 39527598 316 - 1.732 1.642 -0.302
ENSG00000109814 E030 1.0339774 0.0780966376 4.472296e-01 5.886344e-01 4 39527799 39528139 341 - 0.333 0.190 -1.066
ENSG00000109814 E031 0.0000000       4 39528140 39528311 172 -